针刺治疗缺血性脑卒中的Notch信号通路研究进展

doi:10.3969/j.issn.1006-9771.2021.01.010

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (1): 67-70.doi: 10.3969/j.issn.1006-9771.2021.01.010

针刺治疗缺血性脑卒中的Notch信号通路研究进展

王娜娜, 杜小正, 何文洁, 张馨予, 郑欣, 李梦莘

甘肃中医药大学针灸推拿学院，甘肃兰州市 730000

收稿日期:2019-07-31 修回日期:2019-09-16 出版日期:2021-01-25 发布日期:2021-01-27
通讯作者: 杜小正，E-mail： lz-duxiaozheng@163.com
作者简介:王娜娜(1993-)，女，汉族，甘肃静宁县人，硕士研究生，主要研究方向：头针治疗缺血性脑卒中的基础和临床；杜小正(1973-)，男，汉族，甘肃兰州市人，副教授，主要研究方向：传统针刺手法的临床与实验研究。
基金资助:
1.甘肃省中医药管理局科研课题(No. GZK-2017-10);2.甘肃省科技厅创新基地和人才计划(No. 18JR3RA196)

Roles of Notch Signaling Pathway in Acupuncture for Ischemic Stroke (review)

WANG Na-na, DU Xiao-zheng, HE Wen-jie, ZHANG Xin-yu, ZHENG Xin, LI Meng-xin

Department of Acupuncture and Massage, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China

Received:2019-07-31 Revised:2019-09-16 Published:2021-01-25 Online:2021-01-27
Contact: DU Xiao-zheng, E-mail: lz-duxiaozheng@163.com
Supported by:
Gansu Administration of Traditional Chinese Medicine Research Project (No. GZK-2017-10) and Gansu Science and Technology Department Innovation Base and Talent Program (No. 18JR3RA196)

摘要/Abstract

摘要： Notch信号通路是一种进化上高度保守的信号通路途径，缺血可激活该通路，在细胞凋亡、血管生成、神经发生、免疫炎症等方面发挥作用。缺血性脑卒中后针刺治疗，可以影响Notch信号通路相关因子的表达，促进缺血脑组织的神经发生，增强缺血耐受性，抑制细胞凋亡，促使血管生成等。

关键词: 缺血性脑卒中, 针刺, Notch信号通路, 综述

Abstract: Notch signaling pathway is a highly conserved signaling pathway in evolution, which would be activated to play a role in apoptosis, angiogenesis, neurogenesis, immune inflammation and others after ischemia. After acupuncture for ischemic stroke, the expression of Notch signaling pathways related factors increase, which may play a role in neurogenesis, ischemic tolerance, apoptosis, angiogenesis, and so on.

Key words: ischemic stroke, acupuncture, Notch signaling pathway, review

中图分类号:

R743.32

王娜娜, 杜小正, 何文洁, 张馨予, 郑欣, 李梦莘. 针刺治疗缺血性脑卒中的Notch信号通路研究进展[J]. 《中国康复理论与实践》, 2021, 27(1): 67-70.

WANG Na-na, DU Xiao-zheng, HE Wen-jie, ZHANG Xin-yu, ZHENG Xin, LI Meng-xin. Roles of Notch Signaling Pathway in Acupuncture for Ischemic Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(1): 67-70.

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针刺治疗缺血性脑卒中的Notch信号通路研究进展

Roles of Notch Signaling Pathway in Acupuncture for Ischemic Stroke (review)

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