肾小球滤过率评估公式在脊髓损伤患者中的应用进展

doi:10.3969/j.issn.1006-9771.2021.02.004

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (2): 145-149.doi: 10.3969/j.issn.1006-9771.2021.02.004

肾小球滤过率评估公式在脊髓损伤患者中的应用进展

谢杨^1,²,陈振波^1,²,杨吉刚³()

^1.首都医科大学康复医学院，北京市 100068
^2.中国康复研究中心北京博爱医院影像科，北京市 100068
^3.首都医科大学附属北京友谊医院核医学科，北京市 100050

收稿日期:2020-07-15 修回日期:2020-11-28 出版日期:2021-02-25 发布日期:2021-02-26
通讯作者: 杨吉刚 E-mail:13681221974@163.com
作者简介:谢杨(1990-)，男，汉族，北京市人，硕士研究生，初级技师，主要研究方向：影像医学与核医学。
基金资助:
国家自然科学基金项目(81971642)

Advance in Evaluation Formula of Glomerular Filtration Rate in Patients with Spinal Cord Injury (review)

Yang XIE^1,²,Zhen-bo CHEN^1,²,Ji-gang YANG³()

^1.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
^2.Medical Imaging Department, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
^3.Nuclear Medicine Department, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2020-07-15 Revised:2020-11-28 Published:2021-02-25 Online:2021-02-26
Contact: Ji-gang YANG E-mail:13681221974@163.com
Supported by:
National Natural Science Foundation of China(81971642)

摘要/Abstract

摘要：

脊髓损伤患者存在罹患慢性肾脏疾病(CKD)的高风险，肾小球滤过率(GFR)是常用来检测CKD的一个重要指标。本文回顾现有的内源性和外源性GFR测量方法的优劣，并且重点分析GFR评估公式(eGFR)在脊髓损伤患者中应用产生的问题和面临的挑战。eGFR对脊髓损伤患者的适用性依然存在不足，有必要在脊髓损伤临床研究及应用中进行改良。

关键词: 脊髓损伤, 慢性肾脏疾病, 肾小球滤过率, 测量, 评估公式, 综述

Abstract:

Patients with spinal cord injury are in high risk of chronic kidney disease (CKD). Glomerular filtration rate (GFR) is an important indicator commonly used to detect CKD. This paper reviewed the pros and cons of existing endogenous and exogenous GFR measurement, and focused on the problems and challenges for the application of the estimating glomerular filtration rate (eGFR) in patients with spinal cord injury. These research results indicated that the applicability of traditional eGFR to patients with spinal cord injury is still insufficient. It is necessary to modify eGFR in clinical research and application in spinal cord injury.

Key words: spinal cord injury, chronic renal disease, glomerular filtration rate, measurement, evaluation formula, review

中图分类号:

R651.2

谢杨,陈振波,杨吉刚. 肾小球滤过率评估公式在脊髓损伤患者中的应用进展[J]. 《中国康复理论与实践》, 2021, 27(2): 145-149.

Yang XIE,Zhen-bo CHEN,Ji-gang YANG. Advance in Evaluation Formula of Glomerular Filtration Rate in Patients with Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(2): 145-149.

参考文献 35

1	郭慧娟,姜健,张伟. 慢性肾脏病病人血清胱抑素C水平与肾小球滤过率的相关性分析[J]. 蚌埠医学院学报, 2017, 42(6): 811-813.
	Guo H J, Jiang J, Zhang W. Correlation analysis between serum cystatin C and glomerular filtration rate in patients with chronic kidney disease [J]. J Bengbu Med College, 2017, 42(6): 811-813.
2	翁敏,白云凯,毕丹青,等. 肾小球滤过率评估方程在我国慢性肾脏病人中的适用性[J]. 陕西医学杂志, 2009, 38(3):317-319.
	Weng M, Bai Y K, Bi D Q, et al. Applicability of glomerular filtration rate evaluation equation in Chinese patients with chronic kidney disease [J]. Shaanxi Med J, 2009, 38(3): 317-319.
3	马迎春,左力,王梅,等. 肾小球滤过率评估方程在慢性肾脏病不同分期中的适用性[J]. 中华内科杂志, 2005, 44(4): 285-289.
	Ma Y C, Zuo L, Wang M, et al. The application of glomerular filtration rate estimation equations in different stages of chronic kidney disease [J]. Chin J Inter Med, 2005, 44(4): 285-289.
4	李卓文,宁博,张国玲,等. 不同公式计算肾脏深度对肾动态显像测定肾小球滤过率的影响[J]. 中国中西医结合影像学杂志, 2019, 17 (4): 366-368.
	Li Z W, Ning B, Zhang G L, et al. Effect of kidney depth calculated by different formulas on the GFR determined by renal dynamic imaging [J]. Chin Imag J Integrated Trad Western Med, 2019, 17(4): 366-368.
5	Anastasio P, Cirillo M, Santoro D, et al. Measurement of glomerular filtration rate by the ^99mTc-DTPA renogram is less precise than measured and predicted creatinine clearance [J]. Nephron, 1999, 81(2): 136-140.
6	柴立超,王晶,魏雁,等. 不同肾小球滤过率计算方法评估慢性肾脏病患者GFR的对比研究[J]. 临床肾脏病杂志, 2019, 19(7): 498-501.
	Chai L C, Wang J, Wei Y, et al. A comparative study of different calculating methods of glomerular filtration rate for evaluating GFR in patients with chronic kidney disease [J]. J Clin Nephrol, 2019, 19(7): 498-501.
7	谭茹瑜,吴蔚桦,李莹,等. 用~(99m)Tc-DTPA双血浆法评估肾小球滤过率公式的准确性[J]. 海南医学院学报, 2019, 25(19): 1481-1486.
	Tan R Y, Wu W H, Li Y, et al. Study on accuracy of glomerular filtration rate formulas by ^99mTc-DTPA double plasma method [J]. J Hainan Med Univ, 2019, 25(19): 1481-1486.
8	Grubb A, Blirup-Jensen S, Lindström V, et al. First certified reference material for cystatin C in human serum ERM-DA471/IFCC [J]. Clin Chem Lab Med, 2010, 48(11): 1619-1621.
9	Cockcroft D W, Gault H. Prediction of creatinine clearance from serum creatinine [J]. Nephron, 1976, 16(1): 31-41.
10	Levey A S, Bosch J P, Lewis J B, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation [J]. Ann Internal Med, 1999, 130(6): 461-470.
11	Levey A S, Coresh J, Greene T, et al. Using standardized serum creatinine values in the Modification of Diet in Renal Disease study equation for estimating glomerular filtration rate [J]. Ann Internal Med, 2006, 145(4): 247-254.
12	付帅,李晓宁. 肾小球滤过率计算公式研究进展:从Cockcroft-Gault公式到FAS公式[J]. 临床肾脏病杂志, 2020, 20(1): 73-77.
	Fu S, Li X N. The research development of formulas for calculating glomerular filtration rate: from Cockcroft-Gault formula to full age spectrum (FAS) formula [J]. J Clin Nephrol, 2020, 20(1): 73-77.
13	Levey A S, Coresh J, Bolton K, et al. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification [J]. Am J Kidney Dis, 2002, 39(2): S1-S266.
14	Ma Y C, Zuo L, Chen J H, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease [J]. J Am Soc Nephrol, 2006, 17(10): 2937-2944.
15	Kong X, Ma Y, Chen J, al et; Chinese eGFR Investigation Collaboration. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population [J]. Nephrol Dial Transplant, 2013, 28(3): 641-651.
16	Ma Y C, Zuo L, Chen J H, et al. Improved GFR estimation by combined creatinine and cystatin C measurements [J]. Kidney Int, 2007, 72(12): 1535-1542.
17	Levey A S, Stevens L A, Schmid C H, et al. A new equation to estimate glomerular filtration rate [J]. Ann Intern Med, 2009, 150(9): 604-612.
18	Chi X H, Li G P, Wang Q S, et al. CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equation seems more suitable for Chinese patients with chronic kidney disease than other equations [J]. BMC Nephrology, 2017, 18(1): 226.
19	张桂霞,蒋克国,袁亮,等. 3种CKD-EPI 方程评估肾小球滤过率的比较[J]. 安徽医科大学学报, 2015, 50(1): 66-69.
	Zhang G X, Jiang K G, Yuang L, et al. Comparisons among three CKD-EPI equations for estimation of glomerular filtration rate [J]. Acta Univ Med Anhui, 2015, 50(1): 66-69.
20	Kirshblum S C, Waring W, Biering-Sorensen F, et al. Reference for the 2011 revision of the International Standards for Neurological Classification of Spinal Cord Injury [J]. J Spinal Cord Med, 2011, 34(6): 547-554.
21	黄晖,王广积. 脊髓损伤后肌肉萎缩基因谱的生物信息学分析[J]. 中国组织工程研究, 2019, 23(27): 4269-4274.
	Huang H, Wang G J. Bioinformatics analysis of gene spectrum of muscle atrophy after spinal cord injury [J]. Chin J Tissue Engineer Res, 2019, 23(27): 4269-4274.
22	范晓华,纪树荣,周红俊. 减重步行训练对脊髓损伤患者下肢骨骼肌萎缩与步行功能的影响[C]. 中华医学会第八次全国物理医学与康复学学术会议论文汇编, 2006: 200-203.
	Fan X H, Ji S R, Zhou H J. Effect of weight-loss walking training on lower limb skeletal muscle atrophy and walking function in patients with spinal cord injury [C]. The 8th National Conference on Physical Medicine and Rehabilitation of Chinese Medical Association, 2006: 200-203.
23	李立平,陈献. 康复护理对脊髓损伤患者ADL及并发症发生率的影响[J]. 中医药导报, 2007, 13(10): 57-75.
	Li L P, Chen X. Effect of rehabilitation nursing on ADL and incidence of complication in the patient with spinal cord injury [J]. Guide J Tradit Chin Med Pharm, 2007, 13(10): 57-75.
24	施春娟. 综合护理对脊柱骨折合并脊髓损伤患者并发症发生率的影响研究[J]. 当代护士(学术版), 2018, 25(12): 39-40.
	Shi C J. Effect of comprehensive nursing on the incidence of complications in patients with spinal fracture and spinal cord injury [J]. Today Nurse, 2018, 25(012): 39-40.
25	Jenkins M A, Brown D J, Ierino F L, et al. Cystatin C for estimation of glomerular filtration rate in patients with spinal cord injury. [J]. Ann Clin Biochem, 2003, 40(Pt 4): 364.
26	Rabadi M H, Aston C E. Compare serum creatinine versus renal ^99mTc-DTPA scan determined glomerular filtration rates in veterans with traumatic spinal cord injury and meurogenic bladder [J]. J Spinal Cord Med, 2016, 39(6): 638-644.
27	Goto T, Kawasaki Y, Takemoto J, et al. Accuracy of estimated glomerular filtration rates based on creatinine or cystatin C for patients with chronic spinal cord injury [J]. Neurourol Urodyn, 2016, 35(5): S164-S166.
28	马迎春,左力,陈亮,等. 成年健康个体肾小球滤过率正常范围的研究[J]. 临床内科杂志, 2011, 28(1): 38-41.
	Ma Y C, Zuo L, Chen L, et al. The normal range of glomerular filtration rate in Chinese apparently healthy adults [J]. J Clin Inter Med, 2011, 28(1): 38-41.
29	Elmelund M, Oturai P S, Biering S, et al. 50 years follow-up on plasma creatinine levels after spinal cord injury [J]. Spinal Cord, 2014, 52(5): 368-372.
30	Erlandsen E J, Hansen R M, Randers E, et al. Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries [J]. Spinal Cord, 2012, 50(10): 778-783.
31	Stevens L A, Schmid C H, Greene T, et al. Factors other than glomerular filtration rate affect serum cystatin C levels [J]. Kidney Int, 2009, 75(6): 652-660.
32	Zhang J Y, Ding R T, Xian Q Z, et al. Serum cystatin C is increased in acute spinal cord injury: a multicentre retrospective study [J]. Spinal Cord, 2019, 58(3): 1-7.
33	Mohler J L, Barton S D, Blouin R A, et al. The evaluation of creatinine clearance in spinal cord injury patients [J]. J Urol, 1986, 136(2): 366-369.
34	Ma Y C, Zuo L, Su Z M, et al. Distribution of reference GFR in a development population: a critical factor for the establishment of a GFR estimation equation [J]. Clin Nephrol, 2011, 76(4): 296-305.
35	Chikkalingaiah K B, Grant N D, Mangold T M, et al. Performance of simplified Modification of Diet in Renal Disease and Cockcroft-Gault equations in patients with chronic spinal cord injury and chronic kidney disease [J]. Am J Med Sci, 2010, 339(2): 108-116.

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肾小球滤过率评估公式在脊髓损伤患者中的应用进展

Advance in Evaluation Formula of Glomerular Filtration Rate in Patients with Spinal Cord Injury (review)

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