健康女性强烈排尿感脑功能网络的小世界特征

doi:10.3969/j.issn.1006-9771.2021.05.003

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (5): 510-515.doi: 10.3969/j.issn.1006-9771.2021.05.003

健康女性强烈排尿感脑功能网络的小世界特征

英小倩^1,³,高轶⁴,廖利民^1,²()

^1.首都医科大学康复医学院，北京市 100068
^2.中国康复研究中心北京博爱医院，泌尿外科，北京市 100068
^3.中国康复研究中心北京博爱医院，神经泌尿科，北京市 100068
^4.首都医科大学泌尿外科学系，北京市 100069

收稿日期:2021-01-16 修回日期:2021-03-12 出版日期:2021-05-25 发布日期:2021-05-26
通讯作者: 廖利民 E-mail:lmliao@263.net
作者简介:英小倩(1987-)，女，汉族，山东临沂市人，博士研究生，医师，主要研究方向：神经泌尿学与尿动力学，脊髓损伤康复|廖利民(1964-)，男，四川高县人，博士，教授、主任医师，博士生导师，主要研究方向：神经泌尿学与尿动力学。
基金资助:
国家自然科学基金项目(81870523)

Small-world Network Features of Brain Functional Network as Strong Void Perception for Healthy Female

Xiao-qian YING^1,³,Yi GAO⁴,Li-min LIAO^1,²()

^1.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
^2.Department of Urology, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
^3.Department of Neurourology, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
^4.Department of Urology, Capital Medical University, Beijing 100069, China

Received:2021-01-16 Revised:2021-03-12 Published:2021-05-25 Online:2021-05-26
Contact: Li-min LIAO E-mail:lmliao@263.net
Supported by:
National Natural Scientific Foundation of China(81870523)

摘要/Abstract

摘要： 目的

分析同步尿动力监测下健康女性强烈排尿感时大脑功能网络连接的小世界特征。

方法

2017年至2018年，招募21例健康女性受试者，在膀胱空虚和强烈排尿感时分别进行大脑静息态功能磁共振扫描。采用Pearson相关分析计算大脑功能连接矩阵；采用配对t检验和Bonferroni校正对膀胱空虚和强烈排尿感时大脑功能连接的拓扑属性进行分析，计算功能网络的小世界属性参数集聚系数、特征路径长度、全局效率、局部效率和局部节点效率。

结果

2例因头动剔除。其余19例受试者脑功能网络膀胱空虚和强烈排尿感时均具有小世界属性。在强烈排尿感时，网络的集聚系数、特征路径长度、局部效率降低，全局效率增加(P < 0.05)；左侧额下回和额上回、双侧直回、右侧扣带回、枕中回和颞中回、双侧顶下小叶局部节点效率增加，双侧距状裂周围皮质、舌回和梭状回局部节点效率降低(P < 0.05)。

结论

健康女性在膀胱空虚和强烈排尿感时，脑功能网络都具有低成本、高效率的小世界属性。下尿路功能调控涉及多个脑区组成的复杂脑网络。

关键词: 静息态功能磁共振成像, 脑功能网络, 小世界网络, 尿感, 女性

Abstract: Objective

To identify the small-world network property of brain functional network provoked by a strong desire to void in healthy women.

Methods

From 2017 to 2018, 21 healthy women were enrolled, and scanned with resting-state functional magnetic resonance imaging under the empty bladder and strong desire to void, respectively. Brain connection matrix was established with Pearson's correlation analysis, and the differences in topologic properties between the two conditions were identified with paired t-test and Bonferroni correction. The small-world parameters, named clustering coefficient (C_p), characteristic path length (L_p), global efficiency (E_glob), local efficiency (E_loc) and nodal efficiency (E_nodal) were calculated.

Results

There were two women dropped down because of head moving. For the other 19 women, the brain connection presented a small-world network property under the both conditions. Compared with the empty bladder, C_p, L_p, and E_loc decreased, and E_glob increased under the strong desire to void (P < 0.05); while E_nodalincreased in left inferior frontal gyrus and superior frontal gyrus; right cingulate gyrus, middle occipital gyrus and middle temporal?gyrus; and bilateral gyrus rectus and inferior parietal lobes; and decreased in bilateral fusiform gyrus, calcarine fissure and surrounding, and lingual gyrus (P < 0.05).

Conclusion

Brain functional network presents a small-world network property under both empty bladder and a strong desire to void. The regulation of lower urinary tract function involves the coordination of multiple brain regions.

Key words: resting-state functional magnetic resonance imaging, brain functional network, small-world network, desire to void, female

中图分类号:

R694

英小倩,高轶,廖利民. 健康女性强烈排尿感脑功能网络的小世界特征[J]. 《中国康复理论与实践》, 2021, 27(5): 510-515.

Xiao-qian YING,Yi GAO,Li-min LIAO. Small-world Network Features of Brain Functional Network as Strong Void Perception for Healthy Female[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(5): 510-515.

图/表 4

参考文献 37

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膀胱状态	n	C_p	L_p	E_glob	E_loc
空虚	19	0.25±0.12	0.91±0.15	0.21±0.20	0.35±0.07
充盈	19	0.23±0.09	0.84±0.13	0.23±0.20	0.29±0.05
t值		6.67	3.79	4.17	3.54
P值		0.001	0.031	0.027	0.039

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健康女性强烈排尿感脑功能网络的小世界特征

Small-world Network Features of Brain Functional Network as Strong Void Perception for Healthy Female

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