细胞生长因子在神经康复与神经可塑性中的研究进展

doi:10.3969/j.issn.1006-9771.2021.00.005

《中国康复理论与实践》 ›› 2022, Vol. 28 ›› Issue (2): 175-182.doi: 10.3969/j.issn.1006-9771.2021.00.005

细胞生长因子在神经康复与神经可塑性中的研究进展

李校堃¹(),刘旭²,刘建华^3a,饶志恒¹,Yongde Luo¹,陈轲扬¹,张通^3b

1.温州医科大学国际生长因子研究院,浙江温州市 325035
2.首都医科大学附属北京友谊医院康复科,北京市 100050
3.中国康复研究中心北京博爱医院,a.运动疗法科;b.神经康复中心,北京市 100068

收稿日期:2021-08-10 修回日期:2021-08-21 出版日期:2022-02-25 发布日期:2022-03-09
通讯作者: 李校堃 E-mail:xiaokunli@wmu.edu.cn
作者简介:李校堃(1964-),男,满族,陕西渭南市人,中国工程院院士,教授,博士生导师,主要研究方向：成纤维细胞生长因子与再生修复的调控机制以及临床应用开发。

Progress of cellular growth factors in neurorehabilitation and neuroplasticity

LI Xiaokun¹(),LIU Xu²,LIU Jianhua^3a,RAO Zhiheng¹,Yongde LUO¹,CHEN Keyang¹,ZHANG Tong^3b

1. International Growth Factor Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
2. Department of Rehabilitation, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
3. a. Department of Physical Therapy, b. Department of Neurology, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China

Received:2021-08-10 Revised:2021-08-21 Published:2022-02-25 Online:2022-03-09
Contact: LI Xiaokun E-mail:xiaokunli@wmu.edu.cn

摘要/Abstract

摘要：

细胞生长因子是一类具有刺激细胞生长分裂活性的多肽类因子,具有广泛的生物学作用。细胞生长因子不仅调控机体生长发育等正常生理功能,还在神经损伤等病理过程中调节神经康复及神经可塑性,具体表现为促进神经元存活;促进神经再生,调节突触可塑性;促进细胞分化与血管再生,调节微环境;促进神经纤维髓鞘形成,改善神经传导。本文旨在探讨细胞生长因子在神经康复与神经可塑性中的作用机制和应用,以期提供细胞生长因子在康复领域的研究进展和在临床神经康复治疗中的应用前景。

关键词: 细胞生长因子, 神经康复, 神经可塑性, 综述

Abstract:

With potent biological activities, cellular growth factors are polypeptide factors that primarily stimulate cell growth and proliferation. They participate in the regulation of not only normal physiological functions such as human embryonic development and cell growth, but also neurorehabilitation and neuroplasticity in pathological processes such as nerve injury and recovery. Specifically, cellular growth factors have been shown to promote neuron survival, facilitate nerve regeneration and regulate synaptic plasticity, promote cell differentiation/vascular regeneration and modulate the microenvironment, promote nerve fiber myelination and improve nerve conduction. This review summarized current knowledge on the roles and various growth factors in neurorehabilitation and neuroplasticity, providing an update on potential clinical application of cellular growth factors in the field of neural rehabilitation.

Key words: cellular growth factors, neurorehabilitation, neuroplasticity, review

中图分类号:

R741

李校堃,刘旭,刘建华,饶志恒,Yongde Luo,陈轲扬,张通. 细胞生长因子在神经康复与神经可塑性中的研究进展[J]. 《中国康复理论与实践》, 2022, 28(2): 175-182.

LI Xiaokun,LIU Xu,LIU Jianhua,RAO Zhiheng,Yongde LUO,CHEN Keyang,ZHANG Tong. Progress of cellular growth factors in neurorehabilitation and neuroplasticity[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(2): 175-182.

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细胞生长因子在神经康复与神经可塑性中的研究进展

Progress of cellular growth factors in neurorehabilitation and neuroplasticity

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