《中国康复理论与实践》 ›› 2025, Vol. 31 ›› Issue (7): 830-837.doi: 10.3969/j.issn.1006-9771.2025.07.010

• 应用研究 • 上一篇    下一篇

脊髓损伤神经病理性疼痛的脑电信号特征

李峤桢, 冯枫, 杜霞, 邵雯, 高咪, 惠琳娜, 袁华, 孙晓龙()   

  1. 中国人民解放军空军军医大学第一附属医院(西京医院)康复医学科,陕西西安市 710032
  • 收稿日期:2025-03-24 修回日期:2025-05-02 出版日期:2025-07-25 发布日期:2025-07-30
  • 通讯作者: 孙晓龙(1988-),男,汉族,山东淄博市人,博士,副教授、副主任医师,主要研究方向:神经康复的机制和优化策略。E-mail: xlsun@fmmu.edu.cn
  • 作者简介:李峤桢(1999-),女,苗族,四川内江市人,硕士研究生,主要研究方向:神经康复与神经电生理。
  • 基金资助:
    国家自然科学基金项目(82472593);国家自然科学基金项目(82272591);国家自然科学基金项目(82072534)

Characteristics of electroencephalography in neuropathic pain after spinal cord injury

LI Qiaozhen, FENG Feng, DU Xia, SHAO Wen, GAO Mi, HUI Linna, YUAN Hua, SUN Xiaolong()   

  1. Department of Rehabilitation Medicine, the First Affiliated Hospital of Air Force Medical University of PLA (Xijing Hospital), Xi'an, Shaanxi 710032, China
  • Received:2025-03-24 Revised:2025-05-02 Published:2025-07-25 Online:2025-07-30
  • Contact: SUN Xiaolong, E-mail: xlsun@fmmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82472593);National Natural Science Foundation of China(82272591);National Natural Science Foundation of China(82072534)

摘要:

目的 观察脊髓损伤并发神经病理性疼痛(NP)患者脑电信号特征。

方法 西京医院康复医学科脑电图数据库中2018年1月至2023年11月符合标准的脊髓损伤患者90例,根据病情分为NP组(n = 46)和非NP (NNP)组(n = 44)。比较两组静息态脑电功率和对睁眼的反应性。

结果 与非NP组相比,睁眼时,NP组额叶α和β1频段,中央δ、θ、α1和β1频段,顶叶α和β1频段,颞叶α和β1频段,枕叶α1和β1频段,左枕叶α2频段脑电功率升高(|Z| > 1.998, P < 0.05);闭眼时,前额叶α1和β1频段,右额叶θ频段,额叶α和β1频段,左额叶β2频段,中央δ、α1和β1频段,顶叶α1和β1频段,左顶叶α2和β2频段,右颞叶θ频段,颞叶α和β频段,枕叶α1和β1频段,左枕叶β2频段脑电功率升高(|Z| > 1.970, P < 0.05);右前额叶β1频段,额叶θ、α和β频段,右中央β1频段,顶叶α1和β1频段,右顶叶β2频段,右颞叶δ和θ频段,颞叶α1和β频段,左枕叶α1频段,枕叶β1频段对睁眼的反应性降低(|Z| > 1.967, P < 0.05)。

结论 脊髓损伤并发NP患者静息态脑电功率特征性增高,对睁眼的反应性下降。

关键词: 脊髓损伤, 神经病理性疼痛, 静息态脑电图

Abstract:

Objective To investigate the electroencephalography (EEG) signal characteristics in patients with neuropathic pain (NP) associated with spinal cord injury (SCI).

Methods A total of 90 patients with SCI from January, 2018 to November, 2023 were selected from the EEG database of the Department of Rehabilitation Medicine, Xijing Hospital, and divided into NP group (n = 46) and non-NP group (n = 44) according to their symptoms. The resting-state EEG power and reactivity to eye-opening were compared between two groups.

Results Compared with non-NP group, EEG power increased in frontal lobe in α and β1 bands, central lobe in δ, θ, α1 and β1 bands, parietal lobe in α and β1 bands, temporal lobe in α and β1 bands, left occipital lobe in α2 band, and occipital lobe in α1 and β1 bands (|Z| > 1.998, P < 0.05) in NP group during eye-opening; during eye-closing, EEG power increased in prefrontal lobe in α1 and β1 bands, right frontal lobe in θ band, frontal lobe in α and β1 bands, left frontal lobe in β2 band, central lobe in δ, α1 and β1 bands, parietal lobe in α1 and β1 bands, left parietal lobe in α2 and β2 bands, right temporal lobe in θ band, temporal lobe in α and β bands, occipital lobe in α1 and β1 bands, and left occipital lobe in β2 band (|Z| > 1.970, P < 0.05); while the reactivity to eye-opening decreased in right prefrontal lobe in β1 band, frontal lobe in θ, α and β bands, right central lobe in β1 band, parietal lobe in α1 and β1 bands, right parietal lobe in β2 band, right temporal lobe in δ and θ band, temporal lobe in α1 and β bands, left occipital lobe in α1 band, and occipital lobe in β1 (|Z| > 1.967, P < 0.05).

Conclusion Resting-state EEG power characteristically elevates in NP patients after SCI, and the reactivity to eye-opening reduces.

Key words: spinal cord injury, neuropathic pain, resting-state electroencephalography

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