卒中后失语患者汉语词图匹配任务态脑电的时域及时频特征

doi:10.3969/j.issn.1006-9771.2025.08.011

《中国康复理论与实践》 ›› 2025, Vol. 31 ›› Issue (8): 947-957.doi: 10.3969/j.issn.1006-9771.2025.08.011

卒中后失语患者汉语词图匹配任务态脑电的时域及时频特征

张梓寒¹, 管津智¹, 黄幸², 周莉¹, 张雅宣¹, 张蒙园¹, 常静玲¹()

1.北京中医药大学东直门医院，北京市 100070
2.北京中医药大学第三附属医院，北京市 100029

收稿日期:2025-03-03 修回日期:2025-08-05 出版日期:2025-08-25 发布日期:2025-09-01
通讯作者: 常静玲，女，汉族，博士，主任医师，教授，E-mail： ear6979@163.com。
作者简介:张梓寒(1996-)，女，汉族，重庆市人，博士研究生，主要研究方向：中医药防治脑病的临床与神经电生理研究。
基金资助:
北京市自然科学基金面上项目(7242243);北京中医药大学东直门医院人才培养计划项目(DZMG-LJRC0016);北京中医药大学东直门医院临床研究和成果转化能力提升试点项目(DZMG-XZYY-23008)

Characteristics of time-domain and time-frequency of Chinese word-picture matching task-related electroencephalogram in patients with post-stroke aphasia

ZHANG Zihan¹, GUAN Jinzhi¹, HUANG Xing², ZHOU Li¹, ZHANG Yaxuan¹, ZHANG Mengyuan¹, CHANG Jingling¹()

1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China
2. Beijing Universitity of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

Received:2025-03-03 Revised:2025-08-05 Published:2025-08-25 Online:2025-09-01
Supported by:
Beijing Natural Science Foundation (General)(7242243);Dongzhimen Hospital, Beijing University of Chinese Medicine Talent Cultivation Program(DZMG-LJRC0016);Dongzhimen Hospital, Beijing University of Chinese Medicine Enhancing Clinical Research and Transformation Capacity Pilot Project(DZMG-XZYY-23008)

摘要/Abstract

摘要：

目的探索卒中后失语(PSA)患者任务态脑电时域及时频特征。

方法 2018年1月至2021年12月，于北京中医药大学东直门医院招募PSA患者18例(PSA组)，不定向招募性别、年龄和受教育程度匹配的健康受试者9例(对照组)，两组均采集基于汉语词图匹配任务的脑电数据，分析任务态脑电N400平均振幅及脑区分布和事件相关同步化(ERS)/去同步化(ERD)，PSA组采用汉语标准失语症检查表(CRRCAE)进行评定。

结果 N400效应较明显的脑区为左前额区、中央前额区、右前额区、左中央区和中央区。PSA组前额区N400平均振幅较对照组增加，右侧颞顶区较对照组下降。词图不匹配条件下，FPZ电极N400平均振幅与听理解(r = 0.483, P < 0.05)中度相关，T8电极N400平均振幅与复述(r = 0.584, P < 0.05)、出声读(r = 0.556, P < 0.05)中度相关，P6电极N400平均振幅与说(r = 0.476, P < 0.05)、阅读(r = 0.502, P < 0.05)中度相关；词图匹配条件下，P7电极N400平均振幅与计算(r = -0.481, P < 0.05)中度负相关。与对照组相比，PSA组θ、α频段能量降低伴随ERS缺失，β频段能量增加伴随ERD缺失。

结论 PSA患者执行汉语词图匹配任务时，右颞顶区活动抑制，前额区活动代偿增加；θ、α频段能量降低伴随ERS缺失，β频段能量增加伴随ERD缺失。

关键词: 卒中后失语, 汉语词图匹配任务, 脑电图, 事件相关电位

Abstract:

Objective To explore characteristics of time-domain and time-frequency of task-related electroencephalogram (EEG) in patients with post-stroke aphasia (PSA).

Methods From January, 2018 to December, 2021, 18 PSA patients (PSA group) were recruited from Dongzhimen Hospital, Beijing University of Chinese Medicine, and nine healthy subjects (control group) were recruited with matched gender, age and education level. EEG data based on the Chinese word-picture matching task were collected, and the average amplitude of N400 and event-related synchronization (ERS) /desynchronization (ERD) were analyzed. The PSA group was assessed with Chinese Rehabilitation Research Center Aphasia Examination (CRRCAE).

Results The effect of N400 was significant on left frontal, central frontal, right frontal, left central and central areas. The average amplitude of N400 was higher on the frontal area in PSA group than in the control group, and it was lower on right temporal-parietal area. For word-picture mismatching, average amplitude of N400 at FPZ was moderately correlated with auditory comprehension (r = 0.483, P < 0.05), the average amplitude of N400 at T8 was moderately correlated with repetition (r = 0.584, P < 0.05) and reading aloud (r = 0.556, P < 0.05), and the average amplitude of N400 at P6 was moderately correlated with speaking (r = 0.476, P < 0.05) and reading (r = 0.502, P < 0.05). For word-picture matching, the average amplitude of N400 at P7 was moderately negatively correlated with calculation (r = -0.481, P < 0.05). Compared with the control group, the energy decreased in θ and α frequency bands with absence of ERS in PSA group, and it increased in β frequency band with absence of ERD.

Conclusion The activities of Chinese word-picture matching task-related EEG have been inhibited on right temporal-parietal area for PSA patients, and it compensatively increases on frontal area, while the energy decreases in θ and α frequency bands with ERS deficiency, and increases in β frequency band with ERD deficiency.

Key words: post-stroke aphasia, Chinese word-picture matching task, electroencephalography, event-related potential

张梓寒, 管津智, 黄幸, 周莉, 张雅宣, 张蒙园, 常静玲. 卒中后失语患者汉语词图匹配任务态脑电的时域及时频特征[J]. 《中国康复理论与实践》, 2025, 31(8): 947-957.

ZHANG Zihan, GUAN Jinzhi, HUANG Xing, ZHOU Li, ZHANG Yaxuan, ZHANG Mengyuan, CHANG Jingling. Characteristics of time-domain and time-frequency of Chinese word-picture matching task-related electroencephalogram in patients with post-stroke aphasia[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(8): 947-957.

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组别	性别(男/女)/n	年龄/岁	受教育年限/年
对照组	6/3	52.00±5.60	12.00(7.5，12.0)
PSA组	13/5	54.45±10.18	12.00(11.3，16.0)
t/Z值	-	0.652	-1.457
P值	1.000	0.521	0.145

分项	评分
听理解	25.94±11.41
复述	19.00±8.87
说	11.83±11.96
出声读	14.72±9.89
阅读	25.72±10.69
抄写	6.89±4.90
描写	6.61±8.60
听写	4.22±5.47
计算	10.22±5.64

条件	电极	电极定位	对照组(n = 9)	PSA组(n = 18)	t值	P值
词图匹配	AF3	左前额区	0.84±1.60	-1.56±3.11	-2.166	0.040
	CP4	右中央顶区	-0.36±0.82	0.58±1.05	2.348	0.027
	P7	左顶区	-0.48±1.11	1.21±1.68	2.705	0.012
词图不匹配	FP1	左前额区	0.20±1.58	-1.48±2.15	-2.075	0.048
	FPZ	前额区	-0.55±1.24	-2.06±1.97	-2.080	0.048
	FP2	右前额区	0.44±1.70	-1.17±1.45	-2.562	0.017
	T8	右颞区	-1.39±1.18	0.16±1.71	2.430	0.023
	P6	右顶区	-0.37±1.02	1.10±1.13	3.314	0.003
	P7	左顶区	-0.10±1.25	1.22±1.47	2.298	0.030

卒中后失语患者汉语词图匹配任务态脑电的时域及时频特征

Characteristics of time-domain and time-frequency of Chinese word-picture matching task-related electroencephalogram in patients with post-stroke aphasia

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