卒中后中枢性疼痛相关研究的文献计量分析

doi:10.3969/j.issn.1006-9771.2025.09.007

《中国康复理论与实践》 ›› 2025, Vol. 31 ›› Issue (9): 1038-1049.doi: 10.3969/j.issn.1006-9771.2025.09.007

卒中后中枢性疼痛相关研究的文献计量分析

周新悦¹, 叶睿雪², 马雅琦¹, 许莹¹, 曹珑耀³, 王玉龙²()

¹ 山东中医药大学康复医学院，山东济南市 250355
² 深圳市第二人民医院康复医学科，广东深圳市 518035
³ 深圳大学，广东深圳市 518060

收稿日期:2025-03-28 修回日期:2025-08-28 出版日期:2025-09-25 发布日期:2025-10-10
通讯作者: 王玉龙(1964-)，男，硕士，主任医师、教授，博士研究生导师，主要研究方向：康复评定学、神经康复、肺康复，E-mail： ylwang668@163.com。
作者简介:周新悦(1999-)，女，汉族，四川高县人，硕士研究生，主要研究方向：神经康复、肺康复。
基金资助:
深圳市"医疗卫生三名工程"资助项目(SZSM202111010)

Researches on central post-stroke pain: a bibliometric analysis

ZHOU Xinyue¹, YE Ruixue², MA Yaqi¹, XU Ying¹, CAO Longyao³, WANG Yulong²()

¹ School of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong 250355, China
² Department of Rehabilitation Medicine, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, China
³ Shenzhen University, Shenzhen, Guangdong 518060, China

Received:2025-03-28 Revised:2025-08-28 Published:2025-09-25 Online:2025-10-10
Contact: WANG Yulong, E-mail: ylwang668@163.com
Supported by:
Sanming Project of Medicine in Shenzhen(SZSM202111010)

摘要/Abstract

摘要：

目的分析卒中后中枢性疼痛(CPSP)领域的研究现状、热点及发展趋势。

方法检索Web of Science核心合集数据库建库至2025年4月8日的相关文献，采用CiteSpace 6.4 R1高级版对发文趋势、国家/机构/作者合作网络、关键词和突现词等进行文献计量和可视化分析。

结果共纳入文献119篇。CPSP研究自2002年以来整体呈增长趋势，可分为缓慢发展期(2002年至2015年)和快速增长期(2016年以后)，2024年发文量达到峰值。中国和美国的发文量领先，发文量最大的机构是哈佛大学，亚洲机构贡献发文较多，发文量最多的作者是Gao Ju。关键词共现频率前5位分别为central post-stroke pain、neuropathic pain、pathophysiology、transcranial magnetic stimulation和motor cortex stimulation。关键词聚类分析形成10个聚类，整合为4个核心领域：疼痛类型、临床特征与诊断技术、病理生理机制和治疗策略。spinal cord和molecular expression是近年出现的突现词；pathophysiology突现强度最高。

结论近年来，CPSP领域研究热度显著提升，聚焦病理机制与干预策略。未来应加强基础与临床结合，促进多学科协作和高质量研究。

关键词: 卒中后中枢性疼痛, 热点, 文献计量学

Abstract:

Objective To analyze the research status, hotspots and development trends in the field of central post-stroke pain (CPSP).

Methods Relevant literatures up to April 8, 2025 were retrieved from the Web of Science Core Collection database. CiteSpace 6.4.R1 advanced version was used for bibliometric and visualization analysis of publication trends, country/institution/author collaboration networks, keywords and burst terms.

Results A total of 119 publications were included. Researches on CPSP have shown an overall upward trend since 2002, which could be divided into a slow development period (from 2002 to 2015) and a rapid growth period (from 2016 onwards). The number of published papers reached its peak in 2024. China and the United States led in publication volume. Harvard University was the most productive institution, and Asian institutions contributed a significant number of publications. The most prolific author was Gao Ju. The top five keywords by co-occurrence frequency were central post-stroke pain, neuropathic pain, pathophysiology, transcranial magnetic stimulation and motor cortex stimulation. Keyword clustering analysis generated ten clusters, which were integrated into four core research areas: pain types, clinical characteristics and diagnostic techniques, pathophysiological mechanisms, and treatment strategies. The bursting words included spinal cord and molecular expression in recent years; pathophysiology was the most bursting word.

Conclusion In recent years, researches on CPSP are significantly increasing, focusing on pathophysiological mechanisms and intervention strategies. Future studies should strengthen the integration of basic and clinical research, promote multidisciplinary collaboration, and enhance research quality.

Key words: central post-stroke pain, hotspots, bibliometrics

中图分类号:

R743.3

周新悦, 叶睿雪, 马雅琦, 许莹, 曹珑耀, 王玉龙. 卒中后中枢性疼痛相关研究的文献计量分析[J]. 《中国康复理论与实践》, 2025, 31(9): 1038-1049.

ZHOU Xinyue, YE Ruixue, MA Yaqi, XU Ying, CAO Longyao, WANG Yulong. Researches on central post-stroke pain: a bibliometric analysis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(9): 1038-1049.

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参考文献 38

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排名	国家	发文量/n	中心性
1	China	43	0.00
2	USA	21	0.42
3	Japan	14	0.00
4	South Korea	10	0.00
5	Germany	7	0.18

排名	机构	发文量/n	中心性
1	Harvard University	6	0.07
2	Academia Sinica-Taiwan	6	0.00
3	Air Force Medical University	5	0.06
4	Fo Guang University	5	0.00
5	Yeungnam University	4	0.00

排名	期刊	被引频次	中心性
1	Pain	106	0.04
2	Lancet Neurology	76	0.00
3	Stroke	67	0.02
4	Neurology	66	0.07
5	Brain	63	0.07

排名	第一作者	文献题目	期刊	频次
1	Choi, Hanwool Ryan	Pharmacotherapy to manage central post-stroke pain	CNS Drugs, 2021, 35 (2): 151-160.	15
2	Liampas, Andreas	Prevalence and management challenges in central post-stroke neuropathic pain: a systematic review and meta-analysis	Advances in Therapy, 2020, 37 (7): 3278-3291.	15
3	Hanada, Tomoko	Development and pharmacological verification of a new mouse model of central post-stroke pain	Neuroscience Research, 2013, 78: 72-80.	8
4	Ramger, Benjamin Curtis	Effects of non-invasive brain stimulation on clinical pain intensity and Experimental pain sensitivity among individuals with central post-stroke pain: a systematic review	Journal of Pain Research, 2019, 12: 3319-3329.	8
5	Tianfeng Huang	Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways	JCI Insight, 2020, 5 (20): e139987.	7

卒中后中枢性疼痛相关研究的文献计量分析

Researches on central post-stroke pain: a bibliometric analysis

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排名	作者	国家	发文量/n
1	Gao Ju	中国	5
2	Chen Jun	中国	4
3	Ge Yali	中国	4
4	Huang Tianfeng	中国	3
5	Teixeira, Manoel Jacobsen	巴西	3

排名	关键词	频次	中心性
1	central poststroke pain	70	0.20
2	neuropathic pain	50	0.28
3	pathophysiology	19	0.05
4	transcranial magnetic stimulation	19	0.10
5	motor cortex stimulation	19	0.12
6	stroke	16	0.06
7	post stroke pain	13	0.07
8	animal model	13	0.18
9	activation	12	0.28
10	deep brain stimulation	10	0.18

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