《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (03): 153-155.

• 专题研究 • 上一篇    下一篇

急性脑卒中后抑郁血清单胺类递质的变化

许晶1;孙玉华2   

  1. 1.大连医科大学附属第一医院神经内科 辽宁大连市 116011;2.鞍钢长甸医院神经内科 辽宁省鞍山市 114005
  • 收稿日期:2002-10-14 出版日期:2003-03-25 发布日期:2003-03-25

Change of the concentration of monoamine neurotransmitters in serum in patients with post-stroke depression

XU Jing,SUN Yu-hua   

  1. Department of Neurology,the First Hospital Affiliated to Dalian Medical University,116011 Dalian,Liaoning,China
  • Received:2002-10-14 Published:2003-03-25 Online:2003-03-25

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摘要： 目的探讨急性脑卒中后抑郁血清单胺类递质浓度的变化。方法选择85例急性脑卒中患者,经美国流行病学调查中心抑郁量表(CES-D)筛选及17项汉密尔顿抑郁量表(HAMD)评定,按精神障碍诊断与统计手册第4版(DSM-Ⅳ)标准确定诊断,入选脑卒中后抑郁患者34例(PSD组),脑卒中后无抑郁患者51例(无抑郁组),正常对照20例(正常对照组)。采用荧光分光光度仪测定三组空腹血清单胺类递质的浓度。结果脑卒中后抑郁组血清单胺类递质浓度显著下降。结论脑卒中后抑郁与血清单胺类递质浓度降低有关。

关键词: 脑卒中, 抑郁症, 单胺类递质

Abstract: ObjectiveTo explore the change of the concentration of monoamine neurotransmitters in serum in patients with post stroke depression(PSD).Methods85 patients with acute stroke were screened by Center for Epidemiological Survey,Depression Scale(CES-D) and assessed by Hamilton Depression Scale(HAMD).A clinical diagnostic of depression was made based on Diagnostic and Statistical Mannal of Mental Disorders,edition 4(DSM-Ⅳ).There were 34 patients who involved with depression(PSD group), the others(51 cases) not(no depression group).Other 20 normal persons were chosen as a control(control group). In all patients and control subjects, the concentrations of monoamine neurotransmitters in serum was measured.ResultsThe concentration of monoamine neurotransmitters in serum was significantly lower in patients with post stroke depression.ConclusionsPost stroke depression is related to decrease of concentrations of monoamine neurotransmitters in serum.

Key words: stroke, depression, monoamine neurotransmitters