目的系统评价膀胱内注射肉毒毒素对膀胱疼痛综合征疼痛程度的影响。方法检索Cochrane 图书馆、PubMed、Web of Science、Embase、Springer、Wiley、Science Direct、OVID数据库，搜集膀胱内注射肉毒毒素治疗膀胱疼痛综合征的随机对照试验。由两位研究者根据纳入与排除标准筛选试验，提取资料并进行质量评价后，取治疗前、后视觉模拟评分值，利用Rev-Man 5.2 软件进行Meta分析。结果最终筛选出5 篇符合条件的文献，共纳入218 例患者，其中对照组91 例，膀胱内注射肉毒毒素组127 例。Meta 分析结果显示膀胱内注射肉毒毒素组对疼痛的缓解程度优于对照组。结论膀胱内注射肉毒毒素能够缓解膀胱疼痛综合征的疼痛程度。
张杰1
,
王强2
,
3
,
王增春2
,
3
,
任自刚2
,
3
,
熊巍2
,
3
,
刘海泉2
,
3
,
王俊杰2
,
3
,
范婷婷2
,
3
. 膀胱内注射肉毒毒素对膀胱疼痛综合征疼痛程度影响的Meta分析①[J]. 中国康复理论与实践, 2016
, 22(10)
: 1222
-1226
.
DOI: 10.3969/j.issn.1006-9771.2016.10.024
Objective To systemically evaluate the effect of intravesical Botulinum toxin on pain of patientspain syndrom. Methods The following databases as Cochrane Library, PubMed, Web of Science, Embase, Springer, Wiley, Science Direct, OVID were searched to collect the randomized controlled trials (RCTs) with the treatment of intravesical Botulinum toxin vs. 0.9% sodium chloride for patients with bladder pain syndrome. Two reviewers screened the trials according to the inclusion and exclusion criterias, extracted the data, assessed the quality, and the changes of Visual Analogue Scales (VAS) before and after treatment were used to conduct Meta analysis with RevMan5.2 software. Results Five studies were included with a total of 218 patients, there were 127 cases in intravesical Botulinum toxin group and 91 cases in 0.9% sodium chloride group. Meta analysis showed that the pain relief effect of intravesical Botulinum toxin was better than that of 0.9% sodium chloride. Conclusion Intravesical Botulinum toxin can relieve the pain of patients with bladder pain syndrome.
