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缺氧诱导因子-1α在缺血性脑卒中模型中介导神经干-祖细胞作用机制的研究进展

  • 张东圆 ,
  • 李明 ,
  • 王正则 ,
  • 张文冉 ,
  • 许晓丹 ,
  • 张丽莹 ,
  • 田沈
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  • 中国医科大学附属第四医院神经内科,辽宁沈阳市 110032。
张东圆(1991-),女,汉族,河北滦县人,硕士研究生,主要研究方向:缺血性脑卒中的治疗。

收稿日期: 2016-11-15

  网络出版日期: 2017-03-31

Mechanism of Neural Stem and Progenitor Cells Mediated by Hypoxia Inducible Factor-1α in Ischemic Stroke Model (review)

  • ZHANG Dong-yuan ,
  • LI Ming ,
  • WANG Zheng-ze ,
  • ZHANG Wen-ran ,
  • XU Xiao-dan ,
  • ZHANG Li- ying ,
  • TIAN Shen
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  • Department of Neurology, the Forth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China

Received date: 2016-11-15

  Online published: 2017-03-31

摘要

缺氧诱导因子-1α (HIF-1α)是一种缺氧应答因子。脑缺血缺氧时,HIF-1α表达上调,调控下游基因表达,对脑缺血后能量代谢障碍的改善以及微循环的建立具有重要意义。神经干-祖细胞的再生能促进脑梗死的功能恢复。HIF-1α可能通过Notch通路、Wnt/β-catenin通路等机制,介导神经干-祖细胞增殖、分化。

本文引用格式

张东圆 , 李明 , 王正则 , 张文冉 , 许晓丹 , 张丽莹 , 田沈 . 缺氧诱导因子-1α在缺血性脑卒中模型中介导神经干-祖细胞作用机制的研究进展[J]. 中国康复理论与实践, 2017 , 23(3) : 319 -322 . DOI: 10.3969/j.issn.1006-9771.2017.03.015

Abstract

Hypoxia inducible factor-1α is a kind of hypoxia response factor. Acute cerebral ischemia and anoxia can induce up-regulation of hypoxia inducible factor-1α, and the downstream genes, which plays a role in both the energy metabolism and collateral circulation after cerebral ischemia. Neural stem and progenitor cells regeneration also benefit the functional outcome after ischemic stroke. Hypoxia inducible factor-1α may induce proliferation and differentiation of neural stem and progenitor cells through Notch, Wnt/β-catenin pathways, etc., in the ischemic stroke model.

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