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骨骼肌细胞外基质重塑与胰岛素抵抗的研究进展

  • 杨亚南 ,
  • 吕君君 ,
  • 王柯 ,
  • 刘冬梅
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  • 上海体育学院运动科学学院,上海市200438。
杨亚南(1989-),男,汉族,河南汝州市人,硕士研究生,主要研究方向:慢性病与骨骼肌细胞外基质重塑。

收稿日期: 2016-11-16

  网络出版日期: 2017-05-17

基金资助

1.河南省国际科技合作计划项目(No.144300510056);2.河南省教育厅科学技术研究重点项目(No.14A320014)。 

Remodeling of Skeletal Muscle Extracellular Matrix and Insulin Resistance (review)

  • YANG Ya-nan ,
  • Lü Jun-jun ,
  • WANG Ke ,
  • LIU Dong-mei
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  • School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China

Received date: 2016-11-16

  Online published: 2017-05-17

摘要

骨骼肌细胞外基质(ECM)是肌细胞生存和活动的微环境,其组成成分和结构直接影响肌细胞的活动和功能。在胰岛素抵抗的病理过程中,骨骼肌ECM发生病理性重塑,如胶原蛋白沉积、透明质酸增多、ECM膜蛋白整合素信号通路激活、基质金属蛋白酶和基质金属蛋白酶抑制剂平衡失调。这些病理性变化都会导致胰岛素敏感性下降。

本文引用格式

杨亚南 , 吕君君 , 王柯 , 刘冬梅 . 骨骼肌细胞外基质重塑与胰岛素抵抗的研究进展[J]. 中国康复理论与实践, 2017 , 23(4) : 398 -401 . DOI: 10.3969/j.issn.1006-9771.2017.04.007

Abstract

Skeletal muscle extracellular matrix (ECM) is the microenvironment for muscle cells to survive and function. Changes in ECM components and structure directly affect the activity and function of muscle cells. Pathological remodeling occurs to skeletal muscle ECM in insulin resistance, including collagen deposition, hyaluronan accumulation, activation of membrane protein integrin signaling pathway, and the imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases, while all those would impair the tissue insulin sensitivity.

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