专题 脊髓损伤研究

基于“瘀阻经络”病机探讨自噬与脊髓损伤修复的关系

  • 王玲洁 ,
  • 陈显兵
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  • 湖北民族学院医学院,湖北恩施市 445000。
王玲洁(1990-),女,汉族,湖北武汉市人,硕士研究生,主要研究方向:中医药对于脊髓损伤修复的研究。

收稿日期: 2017-02-08

  修回日期: 2017-03-13

  网络出版日期: 2017-06-27

基金资助

国家自然科学基金项目(No.81660672)

Relationship between Autophagy and Repair of Spinal Cord Injury Based on Pathogenesis of Stasis Obstructing Meridian (review)

  • WANG Ling-jie ,
  • CHEN Xian-bing
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  • Hubei Institute for Nationalities School of Medicine, Enshi, Hubei 445000, China

Received date: 2017-02-08

  Revised date: 2017-03-13

  Online published: 2017-06-27

摘要

脊髓损伤是各种创伤所致的中枢神经系统损伤的一种疾病。研究发现脊髓损伤后自噬水平一定程度的上调能促进脊髓损伤后功能的修复。自噬在应激状态下通过降解体内过多的错误折叠蛋白及受损细胞器,为细胞供能,以维持细胞内环境的稳定。具有活血祛瘀通络功效的中药在治疗脊髓损伤中广泛受到关注,其作用与细胞自噬的调节有着密切的联系。

本文引用格式

王玲洁 , 陈显兵 . 基于“瘀阻经络”病机探讨自噬与脊髓损伤修复的关系[J]. 中国康复理论与实践, 2017 , 23(6) : 654 -656 . DOI: 10.3969/j.issn.1006-9771.2017.06.007

Abstract

Spinal cord injury is a kind of central nervous system injury disease caused by trauma. It was found that the up-regulation of autophagy after spinal cord injury could promote the repair of spinal cord injury. Under the condition of stress, autophagy can reduce the number of misfolded proteins and damaged organelles in cells to maintain the stability of intracellular environment. Chinese medicine with Huoxue Quyu Tongluo (against stasis obstructing meridian) efficacy has attracted much attention in the treatment of spinal cord injury, which may associate with the role of regulation of autophagy.

参考文献

[1] Berlowitz DJ, Wadsworth B, Ross J. Respiratory problems and management in people with spinal cord injury [J]. Breathe, 2016, 12(4): 328-340.
[2] Wang ZY, Lin JH, Muharram A, et al. Beclin-1 mediated autophagy protects spinal cord neurons against mechanical injury-induced apoptosis [J]. Apoptosis, 2014, 19(6): 933-945.
[3] Furlan JC, Sakakibara BM, Miller WC, et al. Global incidence and prevalence of traumatic spinal cord injury [J]. Can J Neurol Sci, 2013, 40(4): 456-464.
[4] Varma AK, Das A, Wallace Gt, et al. Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers [J]. Neurochem Res, 2013, 38(5): 895-905.
[5] Ravikumar B, Sarkar S, Davies JE, et al. Regulation of mammalian autophagy in physiology and pathophysiology [J]. Physiol Rev, 2010, 90(4): 1383-1435.
[6] 王玲洁,王子礼,杜俊龙,等. 中医对脊髓损伤的认识及治疗探析[J]. 湖北民族学院学报(医学版), 2016, 33(4): 62-64.
[7] 刘继生,张泓,许明,等. 基于“督脉乃脑之经络”理论探讨脊髓损伤对大脑的影响及其治疗方法的思考[J]. 中华中医药杂志, 2016, 31(8): 2968-2971.
[8] 刘金辉,易满. 脊髓损伤中医病因病机及认识[J]. 新疆中医药, 2014, 32(5): 116-118.
[9] 杨永杰,龚树全. 黄帝内经[M]. 北京:线装书局, 2009: 68.
[10] 王殿华,陈金亮. 参茸补肾胶囊配以针灸治疗外伤性截瘫60例临床研究[J]. 中成药, 2008, 30(11): 1574-1576.
[11] 胥林波. 督脉与脊髓的关系探析[J]. 现代中西医结合杂志, 2011, 20(30): 3844-3845.
[12] 许健鹏,高文柱. 中医传统康复治疗学[M]. 北京:华夏出版社, 2005: 349-350.
[13] 邓周武,杨梓华,郑南翅. 补阳还五汤加减辅助治疗胸腰椎骨折伴脊髓损伤的可行性研究[J]. 首都食品与医药, 2016(2): 52-53.
[14] 李晓宁,迟蕾. 夹脊配合督脉电针治疗脊髓损伤后功能障碍临床观察[J]. 上海针灸杂志, 2015, 34(10): 972-975.
[15] Kou XJ, Liu XR, Chen XB, et al. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway [J]. Oncotarget, 2016, 7(16): 74484-74495.
[16] Kanki T, Klionsky DJ. The molecular mechanism of mitochondria autophagy in yeast [J]. Mol Microbiol, 2010, 75(4): 795-800.
[17] Komatsu M, Kurokawa H, Waguri S, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 [J]. Nat Cell Biol, 2010, 12(3): 213-223.
[18] Larsen KE, Sulzer D. Autophagy in neurons:a review [J]. Histol Histopathol, 2002, 17(3): 897-908.
[19] Levine B, Yuan J. Autophagy in cell death: an innocent convict? [J]. J Clin Invest, 2005, 115(10): 2679-2688.
[20] Carloni S, Buonocore G, Balduini W, et al. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury [J]. Neurobiol Dis, 2008, 32(3): 329-339.
[21] Chen HC, Fong TH, Hsu PW, et al. Multifaceted effects of rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation and neuroprotection [J]. J Surg Res, 2013, 179(1): 203-210.
[22] Sarkar S, Ravikumar B, Floto RA, et al. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies [J]. Cell Death Differ, 2009, 16(1): 46-56.
[23] Shintani T, Klionky DJ. Autophagy in health and disease: a double-edged sword [J]. Science, 2004, 306(5698): 990-995.
[24] Yan Y, Finkel T. Autophagy as a regulator of cardiovascular redox homeostasis [J]. Free Radic Biol Med, 2017, 109: 108-113. doi:10.1016/j.freeradbiomed.2016.12.003.
[25] 鲍家宽,潘磊,陈培丰. 细胞自噬的发生机制及中医药对其干预作用进展[J]. 上海中医药杂志, 2016, 50(10): 99-102.
[26] 黄丽琼,黄贵华,纪云西,等. 细胞自噬与中医“阴阳”及“气”理论相关性探讨[J]. 辽宁中医杂志, 2014, 41(6): 1147-1149.
[27] 黄贵华,纪云西,吴大力,等. 细胞自噬与中医气虚痰瘀关系探讨[J]. 中医杂志, 2011, 52(20): 1717-1719.
[28] 刘杰民,纪云西,蒋历,等. 细胞自噬是探索中医药微观机制的新思路[J]. 时珍国医国药, 2013, 24(2): 425-426.
[29] 郑洪新. 中医基础理论专题研究[M]. 北京:人民卫生出版社, 2009: 103-104.
[30] 李军艳,杨明会,赵冠英. 试论肾虚血瘀是帕金森病的基本病机[J]. 中华中医药杂志, 2008, 23(9): 768-771.
[31] 郭旭堂,梁健芬,张新博. 从痰瘀机制探讨自噬在帕金森病发展中的作用[J]. 中华中医药杂志, 2015, 30(4): 1201-1204.
[32] 于红红,吴玛莉,冷泠,等. 自噬与动脉粥样硬化的关系及中药的干预作用[J]. 中国动脉硬化杂志, 2014, 22(7): 736-740.
[33] Liao X, Sluimer JC, Wang Y, et al. Macrophage autophagy plays a protective role in advanced atherosclerosis [J]. Cell Metab, 2012, 15(4): 545-553.
[34] Martinet W, De Meyer GRY. Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential [J]. Circ Res, 2009, 104(3): 304-317.
[35] 赵秋振,张辉,薄爱华. 川芎嗪对SH-SY5Y细胞自噬作用的影响[J]. 时珍国医国药, 2011, 22(2): 498-500.
[36] Li CL, Han XC, Zhang H, et al. The interplay between autophagy and apoptosis induced by tanshinone IIA in prostate cancer cells [J]. Tumor Biology, 2016, 37(6): 7667-7674.
[37] Kanno H, Ozawa H, Sekiguchi A, et al. Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice [J]. Spine (Phila Pa 1976), 2011, 36(22): E1427-E1434.
[38] 张廷模,陈先难,周祯祥,等. 临床中药学[M]. 北京:中国中医药出版社, 2004: 553-554.
[39] 俞雪锋,蒋曦,王国康,等. 阿魏酸对脊髓损伤大鼠微管相关蛋白轻链3、Beclin1、 Bcl-2和Bax表达的影响[J]. 中国药理学与毒理学杂志, 2016, 30(7): 1-9.
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