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阿尔茨海默病脑内小胶质细胞的极化状态及电针的影响研究进展

  • 李珑 ,
  • 柳维林 ,
  • 王志福 ,
  • 陶静 ,
  • 陈立典
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  • 福建中医药大学康复医学院,福建福州市 350122。
李珑(1992-),女,汉族,重庆市人,硕士研究生,主要研究方向:神经康复与认知科学研究。

收稿日期: 2017-02-14

  网络出版日期: 2017-08-07

基金资助

福建省康复技术协同创新中心课题(No.755010017-协同)

Role of Microglia Polarization in Alzheimer's Disease and Association to Electroacupuncture (review)

  • LI Long ,
  • LIU Wei-lin ,
  • WANG Zhi-fu ,
  • TAO Jing ,
  • CHEN Li-dian
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  • College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China

Received date: 2017-02-14

  Online published: 2017-08-07

摘要

脑内免疫细胞小胶质细胞有两种极化状态M1和M2。M2状态可吞噬β-淀粉样蛋白、防止Tau蛋白过度磷酸化,还可清除部分病理产物。针刺发挥作用的机制可能与转变小胶质细胞的极化状态有关。

本文引用格式

李珑 , 柳维林 , 王志福 , 陶静 , 陈立典 . 阿尔茨海默病脑内小胶质细胞的极化状态及电针的影响研究进展[J]. 中国康复理论与实践, 2017 , 23(7) : 779 -782 . DOI: 10.3969/j.issn.1006-9771.2017.07.008

Abstract

There are two phenotypes of microglia, M1 and M2. Microglia in M2 polarization may associate with the phagorytosis of beta-amyloid and inhibition of Tau hyperphosphorylation, as well as in other pathology. Electroacupuncture can impact the phenotypes of microglia, which may play a role in the treatment for Alzheimer's disease.

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