《中国康复理论与实践》

中国康复理论与实践 >

2018 , Vol. 24 >Issue 7: 753 - 756

DOI: https://doi.org/10.3969/j.issn.1006-9771.2018.07.001

专题

儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性

  • 马惠姿 ,
  • 马凌燕 ,
  • 冯涛
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  • 1.首都医科大学附属北京天坛医院神经病学中心神经变性病科,北京市 100050;
    2.国家神经系统疾病临床医学研究中心,北京市 100050;
    3.北京脑重大疾病研究院帕金森病研究所,北京市 100050
马惠姿(1962-),女,汉族,北京市人,硕士,副主任医师,主要研究方向：帕金森病、焦虑抑郁及运动障碍病等。通讯作者：冯涛,男,博士,主任医师。

收稿日期: 2018-05-09

  修回日期: 2018-07-09

  网络出版日期: 2018-08-01

基金资助

1.脑重大疾病数据的采集规范及挖掘分析研究(一期)(No. Z151100003915117); 2.北京市自然科学基金项目(No. 7164254); 3.国家自然科学基金面上项目(No. 81571226; No. 81771367); 4.首都特色临床应用研究(No.Z171100001017041); 5.北京市科委基金项目(No. Z151100003915150); 6.“十三五”国家重点研发计划(No. 2016YFC1306501)

收起

Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease

  • MA Hui-zi ,
  • MA Ling-yan ,
  • FENG Tao
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  • 1. Center for Neurodegenerative Disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
    2. China National Clinical Research Center for Neurological Disease, Beijing 100050, China;
    3. Parkinson's Disease Center, Beijing Institute for Brain Disorder, Capital Medical University, Beijing 100050, China

Received date: 2018-05-09

  Revised date: 2018-07-09

  Online published: 2018-08-01

Supported by

Supported by Data Collection and Mining for Major Brain Diseases (No. Z151100003915117), Beijing Natural Science Foundation (No. 7164254), National Natural Science Foundation of China (General) (No. 81571226 and No. 81771367), Capital Clinical Application Research Program (No. Z171100001017041), Beijing Science and Technology Commission Fund (No. Z151100003915150) and National Key Research and Development Program of the 13th Five-Year Plan (No. 2016YFC1306501)

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摘要

目的 探讨儿茶酚胺氧位甲基转移酶(COMT)基因Val158Met多态性与中国帕金森病抑郁的相关性。方法 2016年6月至2017年12月,散发帕金森病患者268例,根据汉密尔顿抑郁量表评定结果分为抑郁组(n=116)和非抑郁组(n=152)。同时招募252例既往健康,无神经系统疾病,性别、年龄与患者相匹配的健康体检者作为对照组。两组留取外周血,提取基因组DNA。采用限制性片段长度多态性-聚合酶链反应(PCR-RELP)和限制性酶切,分析COMT基因Val158Met多态性。结果 抑郁组、非抑郁组、对照组在COMT基因Val158Met位点基因型(χ2=0.78, P>0.05)、等位基因 (χ2=0.25, P>0.05)分布均无显著性差异。结论 COMT基因Val158Met多态性并非中国帕金森病抑郁人群的遗传易感因素。

关键词： 帕金森病; 抑郁; 儿茶酚胺氧位甲基转移酶; Val158Met; 多态性

本文引用格式

马惠姿 , 马凌燕 , 冯涛 . 儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性[J]. 中国康复理论与实践, 2018 , 24(7) : 753 -756 . DOI: 10.3969/j.issn.1006-9771.2018.07.001

Abstract

Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase (COMT) gene Val158Met site and depression in Parkinson's disease. Methods From June, 2016 to December, 2017, a cohort of 268 Chinese patients with Parkinson's disease and 252 age- and gender-matched healthy control subjects were recruited. The patients were divided into depression group (n=116) and non-depression group (n=152) according to Hamilton Depression Scale score. Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results No difference was identified in Val158Met polymorphism of genotype (χ2=0.78, P>0.05) and allele (χ2=0.25, P>0.05) among the depression group, the non-depression group and the control group. Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.

Key words： Parkinson's disease; depression; catechol-O-methyltransferase; Val158Met; polymorphism

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