目的 研究慢性阻塞性肺疾病性周围神经病的神经电生理特点。方法 回顾性分析2016年1月至12月60例慢性阻塞性肺疾病性周围神经病患者的电生理表现,包括正中神经、尺神经、胫神经、腓总神经的运动神经传导速度和复合肌肉动作电位振幅,正中神经、尺神经、胫神经、腓浅神经的感觉神经传导速度和感觉神经动作电位振幅,以及四肢皮肤交感反射。结果 运动和感觉神经动作电位振幅的总异常率显著高于传导速度的总异常率(χ2=190.026, P<0.001);运动与感觉神经之间传导速度异常率接近(χ2=1.538, P>0.05),动作电位振幅异常率接近(χ2=2.839, P>0.05);神经传导总异常率与皮肤交感反射总异常率接近(χ2=0.001, P>0.05);神经传导检测异常率下肢显著高于上肢(χ2=81.114, P<0.001),皮肤交感反射异常率下肢高于上肢(χ2=5.689, P<0.05)。结论 慢性阻塞性肺疾病性周围神经病主要表现为运动感觉性多发性神经病,运动、感觉、自主神经均受累;以轴突损害为主,运动与感觉神经轴突损害程度接近;大小神经纤维同时受累,损害程度无明显差异。
Objective To analyze the neuroelectrophysiological characteristics of peripheral neuropathy after chronic obstructive pulmonary disease. Methods From January to December, 2016, a total of 60 patients of chronic obstructive pulmonary disease with peripheral neuropathy were reviewed the motor conduction velocity and compound muscle action potential amplitude of median, ulnar, tibial, peroneal nerves; the sensory conduction velocity and sensory nerve action potential amplitude of median, ulnar, tibial, superficial peroneal nerves; and the skin sympathetic response of limbs. Results The incidence of abnormalities was higher in amplitude than in conduction velocity of motor nerve and sensory nerves (χ2=190.026, P<0.001). The incidence of abnormal conduction velocity was similar in motor nerve and sensory nerves (χ2=1.538, P>0.05), as well as the abnormal action potential amplitude (χ2=2.839, P>0.05). The incidence of abnormal conduction was similar with abnormal skin sympathetic response (χ2=0.001, P>0.05). The incidence of abnormalities of nerve conduction study (χ2=81.114, P<0.001) and abnormal skin sympathetic response (χ2=5.689, P<0.05) was more in lower limbs than in upper limbs. Conclusion The peripheral neuropathy after chronic obstructive pulmonary disease characters mainly as motor-sensory multiple neuropathy, involving motor, sensory and autonomic nerve. The axonal damage is significant, with the similar severity between motor and sensory nerves, as well as between the large and small nerves.
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