综述

脊髓损伤的代谢组学研究进展

  • 杨新乐 ,
  • 王明 ,
  • 杨成伟 ,
  • 徐雅洁 ,
  • 甄平
展开
  • 1.兰州大学第二医院,甘肃兰州市 730000;
    2.兰州军区兰州总医院全军骨科中心,甘肃兰州市 730050;
    3河南省荣军医院,河南新乡市 453000
杨新乐(1992-),男,满族,河南洛阳市人,硕士研究生,主要研究方向:脊柱脊髓损伤。通讯作者:甄平,男,主任医师,教授,硕士研究生导师,主要研究方向:骨与关节损伤。

收稿日期: 2018-05-10

  修回日期: 2018-05-31

  网络出版日期: 2018-08-20

基金资助

1.国家自然科学基金项目(No. 81601905); 2.中国博士后科学基金项目(No. 2017M623433)

Advance in Metabolomics of Spinal Cord Injury (review)

  • YANG Xin-le ,
  • WANG Ming ,
  • YANG Cheng-wei ,
  • XU Ya-jie ,
  • ZHEN Ping
Expand
  • 1. The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, China;
    2. Department of Orthopaedic, the Lanzhou General Hospital of PLA, Lanzhou, Gansu 730050, China;
    3. Henan Rong Jun Hospital, Xinxiang, Henan 453000, China

Received date: 2018-05-10

  Revised date: 2018-05-31

  Online published: 2018-08-20

Supported by

Supported by National Natural Science Foundation of China (No. 81601905) and China Postdoctoral Science Foundation (No. 2017M623433)

摘要

脊髓损伤常导致机体不同程度的感觉及运动功能障碍,造成永久残疾,且并发症多,难以治愈。代谢组学作为一种新发展的技术,通过分析个体应激后代谢物的变化,找出用于辅助诊断、治疗或判断预后的特异性生物标志物,能够在疾病早期为患者制定最佳的治疗及康复方案。目前已有相关研究在脊髓损伤的诊断、治疗和预后监测等方面取得一定成果,鉴别了一些具有潜在价值的生物标志物,但脊髓损伤后的病理生理机制尚不完全清楚,相关生物标志物也缺少临床试验的验证。

本文引用格式

杨新乐 , 王明 , 杨成伟 , 徐雅洁 , 甄平 . 脊髓损伤的代谢组学研究进展[J]. 中国康复理论与实践, 2018 , 24(8) : 904 -908 . DOI: 10.3969/j.issn.1006-9771.2018.08.007

Abstract

Spinal cord injury (SCI) often causes different degrees of sensory and motor dysfunction, resulting in permanent disability, with many complications and difficult to cure. Metabolomics, as a new developing technique, identifies specific biomarkers for diagnosis, treatment or prognosis judgement by analyzing the changes in the metabolites after individual stress, and can make the best treatment and rehabilitation program for the patients in the early stage of the disease. At present, some achievements have been made in the diagnosis, treatment and prognosis monitoring of spinal cord injury, and some potential biomarkers have been identified. However, the pathophysiology of spinal cord injury is not fully understood, and relevant biomarkers are also lacking in clinical trials.

参考文献

[1] van der Scheer JW, Hutchinson MJ, Paulson T, et al. Reliability and validity of subjective measures of aerobic intensity in adults with spinal cord injury: a systematic review[J]. PM R, 2018, 10(2): 194-207.
[2] Dietz V, Fouad K.Restoration of sensorimotor functions after spinal cord injury[J]. Brain, 2014, 137(Pt 3): 654-667.
[3] Saulino M.Spinal cord injury pain[J]. Phys Med Rehabil Clin N Am, 2014, 25(2): 397-410.
[4] Sohn HM, Hwang JY, Ryu JH, et al.Simvastatin protects ischemic spinal cord injury?from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions[J]. J Orthop Surg Res, 2017, 12(1): 36.
[5] Ur K, Demiroz S, Bengu AS, et al.Serum endocan level and the severity of spinal cord injury[J]. Bratisl Lek Listy, 2018, 119(5): 298-301.
[6] Fehlings MG, Vaccaro A, Wilson JR, et al.Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS)[J]. PLoS One, 2012,7(2): e32037.
[7] Nicholson JK, Connelly J, Lindon JC, et al.Metabonomics: a platform for studying drug toxicity and gene function[J]. Nat Rev Drug Discov, 2002, 1(2): 153-161.
[8] Jacob M, Malkawi A, Albast N, et al.A targeted metabolomics approach for clinical diagnosis of inborn errors of metabolism[J]. Anal Chim Acta, 2018, 1025: 141-153.
[9] Euceda LR, Andersen MK, Tessem MB, et al.NMR-based prostate cancer?metabolomics[J]. Methods Mol Biol, 2018, 1786: 237-257.
[10] Bunge RP, Puckett WR, Hiester ED.Observations on the pathology of several types of human spinal cord injury, with emphasis on the astrocyte response to penetrating injuries[J]. Adv Neurol, 1997, 72: 305-315.
[11] Hagen EM, Rekand T, Gilhus NE, et al.Traumatic spinal cord injuries–incidence, mechanisms and course[J]. Tidsskr Nor Laegeforen, 2012, 132(7): 831-837.
[12] Trivedi A, Olivas AD, Noble-Haeusslein LJ.Inflammation and spinal cord injury: infiltrating leukocytes as determinants of injury and repair processes[J]. Clin Neurosci Res, 2006, 6(5): 283-292.
[13] Siddiqui AM, Khazaei M, Fehlings MG.Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury[J]. Prog Brain Res, 2015, 218: 15-54.
[14] Biglari B, Swing T, Child C, et al.A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of TNF-α in acute SCI patients as a possible marker for neurological remission[J]. Spinal Cord, 2015, 53(7): 510-514.
[15] Gensel JC, Zhang B.Macrophage activation and its role in repair and pathology after?spinal cord injury[J]. Brain Res, 2015, 1619: 1-11.
[16] Gaudet AD, Popovich PG.Extracellular matrix regulation of?inflammation in the healthy and injured spinal cord[J]. Exp Neurol, 2014, 258: 24-34.
[17] Mazzon E, Bruscoli S, Galuppo M, et al.Glucocorticoid-induced leucine zipper (GILZ) controls?inflammation?and tissue damage after?spinal cord injury[J]. CNS Neurosci Ther, 2014, 20(11): 973-981.
[18] Hulme CH, Brown SJ, Fuller HR, et al.The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood[J]. Spinal Cord, 2017, 55(2): 114-125.
[19] Lukovic D, Stojkovic M, Moreno-Manzano V, et al.Concise review: reactive astrocytes and stem?cells?in?spinal cord injury: good guys or bad guys?[J]. Stem Cells, 2015, 33(4): 1036-1041.
[20] Ruschel J, Hellal F, Flynn KC, et al.Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after?spinal cord injury[J]. Science, 2015, 348(6232): 347-352.
[21] Hirokawa T, Zou Y, Kurihara Y, et al.Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS[J]. Sci Rep, 2017, 7(1): 12119.
[22] Dyck S, Kataria H, Alizadeh A, et al.Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following?spinal cord injury[J]. J Neuroinflammation, 2018, 15(1): 90.
[23] Dou F, Huang L, Yu P, et al.Temporospatial expression and cellular localization of oligodendrocyte myelin glycoprotein (OMgp) after traumatic spinal cord injury in adult rats[J]. J Neurotrauma, 2009, 26(12): 2299-2311.
[24] 坊爱红,张婷,孙丽,等. 脊髓损伤治疗的研究进展[J]. 中国综合临床, 2018, 34(1): 75-78.
[25] 杜盛超,张玮,胡浩然,等. 低温在脊髓损伤治疗中应用的研究进展[J]. 现代生物医学进展, 2017, 17(11): 2194-2196, 2177.
[26] Koda M, Nishio Y, Kamada T, et al.Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice[J]. Brain Res, 2007, 1149: 223-231.
[27] 沈朝兰,李楚,朱晓波,等. 双孔钾离子通道激动剂利鲁唑对叔丁基过氧化氢诱导的人视网膜色素上皮细胞氧化损伤的作用[J]. 中华眼底病杂志, 2013, 29(4): 400-405.
[28] De Preter V.Metabonomics and systems biology[J]. Methods Mol Biol, 2015, 1277: 245-255.
[29] Taylor J, King RD, Altmann T, et al.Application of metabolomics to plant genotype discrimination using statistics and machine learning[J]. Bioinformatics, 2002, 18(Suppl 2): S241-S248.
[30] Kwon BK, Streijger F, Fallah N, et al.Cerebrospinal fluid biomarkers to stratify injury severity and predict outcome in human traumatic spinal cord injury[J]. J Neurotrauma, 2017, 34(3): 567-580.
[31] Pouw MH, Kwon BK, Verbeek MM, et al.Structural biomarkers in the cerebrospinal fluid within 24?h after a traumatic spinal cord injury: a descriptive analysis of 16 subjects[J]. Spinal Cord, 2014, 52(6): 428-433.
[32] Mori H, Hosoda K, Matsubara E, et al.Tau in cerebrospinal fluids: establishment of the sandwich ELISA with antibody specific to the repeat sequence in tau[J]. Neurosci Lett, 1995, 186(2-3): 181-183.
[33] Wolf H, Krall C, Pajenda G, et al.Alterations of the biomarker S-100B and NSE in patients with acute vertebral spine fractures[J]. Spine J, 2014, 14(12): 2918-2922.
[34] Shaw G, Yang C, Ellis R, et al.Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury[J]. Biochem Biophys Res Commun, 2005, 336(4): 1268-1277.
[35] Lubieniecka JM, Streijger F, Lee JH, et al.Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats[J]. PLoS One, 2011, 6(4): e19247.
[36] Sengupta MB, Basu M, Iswarari S, et al.CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury[J]. PLoS One, 2014, 9(10): e110885.
[37] Xu D, Omura T, Masaki N, et al.Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury[J]. Sci Rep, 2016, 6: 26427.
[38] Kuhle J, Gaiottino J, Leppert D, et al.Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome[J]. J Neurol Neurosurg Psychiatry, 2015, 86(3): 273-279.
[39] Vijayaprakash KM, Sridharan N.An experimental spinal cord injury rat model using customized impact device: a cost-effective approach[J]. J Pharmacol Pharmacother, 2013, 4(3): 211-213.
[40] McDonough A, Monterrubio A, Ariza J, et al. Calibrated forceps model of spinal cord compression injury [J]. J Vis Exp, 2015(98). doi: 10.3791/52318.
[41] Fouad K, Schnell L, Bunge MB, et al.Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord[J]. J Neurosci, 2005, 25(5): 1169-1178.
[42] Fujieda Y, Ueno S, Ogino R, et al.Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats[J]. PLoS One, 2012, 7(8): e43152.
[43] Peng J, Zeng J, Cai B, et al.Establishment of quantitative severity evaluation model for spinal cord injury by metabolomic fingerprinting[J]. PLoS One, 2014, 9(4): e93736.
文章导航

/