目的 构建反映实际功能脑区连接的脑皮质功能网络,研究刺激不同经络穴位的大脑协同调控机制。方法 2017年10月至11月,采用128导脑电记录分析系统同步采集14例(男性8例,女性6例)年龄21~25岁的健康被试在静息态、磁刺激光明穴(GB37)和内关穴(PC6)时的脑电信号;利用组独立成分分析、标准低分辨率脑电磁断层成像方法对各状态脑电信号溯源并计算脑电成分的统计关系;基于复杂网络理论构建对应的α波脑皮质功能网络并进行拓扑结构分析。结果 刺激光明穴时与运动、视觉等相关的脑区在网络中的连接增多;刺激内关穴时与运动、注意力及工作记忆等相关的脑区在网络中连接减少;刺激两个穴位时激活了一些相同的脑区,且一些脑区功能连接变化趋势相似。结论 磁刺激位于不同经络的光明穴和内关穴时脑网络拓扑结构的改变与穴位自身功效基本相符,但也会引起一些脑区功能连接的相似变化。
Objective To study the coordination mechanism of brain induced by stimulating on acupoints of different meridians by means of constructing cerebral cortex functional networks reflecting actual brain functional connections. Methods A 128-lead electroencephalogram (EEG) recording and analysis system was used to collect the EEG signals of 14 healthy subjects (eight males and six females) aged 21 to 25 in resting state and magnetic stimulation on the acupuncture points of Guangming (GB37) and Neiguan (PC6) located in different meridians from October to November, 2017. Then EEG sources were localized by group independent component analysis and standard low-resolution brain electromagnetic tomography, and the statistical relationships of EEG components were calculated. Finally, alpha-wave cerebral cortex functional networks were constructed and analyzed based on complex network theory. Results The connections of brain regions associated with movement, vision increased in the stimulation of Guangming acupoint. The brain regions associated with movement, attention and working memory in the stimulation of the Neiguan acupoint were reduced in the network. Some common brain areas were activated and some changes of functional connections were similar. Conclusion The changes in the topological structure of brain networks are basically consistent with the efficacy of the acupuncture point during magnetic stimulation on Guangming and Neiguan of different meridians, however, it causes some similar changes in functional connectivity connections of some brain regions.
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