综述

脑缺血后周细胞及相关血管生成信号通路的研究进展

  • 张荻 ,
  • 徐鸣曙 ,
  • 张英杰 ,
  • 程爱芳 ,
  • 管华宗
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  • 1.上海中医药大学,上海市 200120
    2.上海市针灸经络研究所,上海市 200030
张荻(1992-),女,汉族,浙江嘉兴市人,硕士研究生,主要研究方向:针灸治疗神经系统疾病。

收稿日期: 2018-08-30

  修回日期: 2018-10-19

  网络出版日期: 2019-05-29

基金资助

1.上海市科学技术委员会科研计划项目(No. 17ZR1427500);2.上海市卫生和计划生育委员会科研课题计划项目(No. 201640128)

Advance in Pericytes and Related Angiogenic Signaling Pathways after Cerebral Ischemia (review)

  • ZHANG Di ,
  • XU Ming-shu ,
  • ZHANG Ying-jie ,
  • CHENG Ai-fang ,
  • GUAN Hua-zong
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  • 1.Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China
    2.Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China

Received date: 2018-08-30

  Revised date: 2018-10-19

  Online published: 2019-05-29

Supported by

Shanghai Committee of Science and Technology Research Plan (No. 17ZR1427500) and Shanghai Municipal Commission of Health and Family Planning Research Plan (No. 201640128)

摘要

周细胞与内皮细胞、星形胶质细胞以及胞外间隙共同构成血脑屏障(BBB),周细胞与内皮细胞通过各种机制通路参与多种BBB的功能调节,共同维持神经血管单元(NVU)的稳定。NVU的损伤与修复涉及诸多分子水平的信号传递。血管生成主要是内皮细胞的发生成熟和周细胞的支持黏附过程。本文主要就目前NVU缺血损伤后周细胞与内皮细胞相关的血管生成信号通路研究进行综述。

本文引用格式

张荻 , 徐鸣曙 , 张英杰 , 程爱芳 , 管华宗 . 脑缺血后周细胞及相关血管生成信号通路的研究进展[J]. 中国康复理论与实践, 2019 , 25(5) : 534 -539 . DOI: 10.3969/j.issn.1006-9771.2019.00.002

Abstract

Pericytes, endothelial cells (EC), astrocytes and extracellular space together constitute the blood-brain barrier. Pericytes and EC participate in the various regulations of blood-brain barriers through many mechanisms to maintain the stability of neurovascular units (NVU). The injury and repair of NVU involve a lot of signal transduction at molecular levels, and angiogenesis is primarily about the generation and maturation of EC and the supporting adhesion process of pericytes. This article briefly reviewed EC-related angiogenesis signaling pathways in pericytes after NVU ischemic injury.

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