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脑卒中后执行功能障碍的评估与康复研究进展

  • 刘远文 ,
  • 罗婧 ,
  • 方杰 ,
  • 潘翠环
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  • 1.中山大学附属第三医院康复医学科,广东广州市 510630
    2.厦门弘爱康复医院,福建厦门市 361006
    3.广州医科大学附属第二医院康复医学科,广东广州市 510260
刘远文(1990-),男,汉族,广东河源市人,硕士,治疗师,主要研究方向:认知障碍评估与康复治疗。|潘翠环(1957-),女,教授、主任医师,硕士生导师,主要研究方向:神经康复及康复治疗教育。

收稿日期: 2019-12-24

  修回日期: 2020-02-04

  网络出版日期: 2020-07-24

基金资助

国家自然科学基金项目(81702232);广东省医学科学技术研究基金项目(A2016251);广东省自然科学基金项目(2017A030313586)

Advance in Evaluation and Rehabilitation for Post-stroke Executive Impairment (review)

  • Yuan-wen LIU ,
  • Jing LUO ,
  • Jie FANG ,
  • Cui-huan PAN
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  • 1. Department of Rehabilitation Medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, China
    2. Xiamen Humanity Rehabilitation Hospital, Xiamen, Fujian 361006, China
    3. Department of Rehabilitation Medicine, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, China

Received date: 2019-12-24

  Revised date: 2020-02-04

  Online published: 2020-07-24

Supported by

National Natural Science Foundation of China(81702232);Guangdong Medical Science and Technology Foundation(A2016251);Natural Science Foundation of Guangdong(2017A030313586)

摘要

执行功能障碍是脑卒中常见后遗症之一,患者不能很好控制自己的思想、情感和行为,其病因学尚不明确,主要涉及额叶、前扣带回、脑桥等。目前尚无特异性测评工具,神经心理学评估是目前筛查和诊断的重要手段,可分为筛查法和专项检查法。筛查法可快速判断执行功能障碍,但不能作为诊断依据;专项检查法费时,难度偏大,不易获得受试者配合。康复策略包括恢复性、代偿性和适应性策略。药物治疗是主要方法,但疗效不理想。认识训练、计算机辅助认知训练、经颅直流电刺激等方法逐渐得到应用。影像学和神经电生理技术等客观评价方法会在未来得到更多应用。

本文引用格式

刘远文 , 罗婧 , 方杰 , 潘翠环 . 脑卒中后执行功能障碍的评估与康复研究进展[J]. 中国康复理论与实践, 2020 , 26(7) : 788 -792 . DOI: 10.3969/j.issn.1006-9771.2020.07.010

Abstract

Executive impairment is common after stroke, which causes in disabilities for controling thinking, emotion and behavior. The etiology is uncertain. There is no specific assessment tool for it. The psychological assessment is the main approach to screen and diagnose executive impairment, including screening and specific examination. There are still some advantages and disadvantages. The strategy for rehabilitation includes recovery, compulsory and adaptive treatment. Medication is the main treatment, but still unsatisfactory. Cognitive training, computer-assisted cognitive rehabilitation and transcranial direct current stimulation and so on are applied. Imaging and physiological electrical techniques are needed.

参考文献

[1] Oveisgharan S, Hachinski V. Executive dysfunction is a strong stroke predictor[J]. J Neurol Sci, 2015, 349(1-2): 161-167.
[2] Middleton L E, Lam B, Fahmi H, et al. Frequency of domain-specific cognitive impairment in sub-acute and chronic stroke[J]. NeuroRehabilitation, 2014, 34(2): 305-312.
[3] Brookes R L, Herbert V, Paul S, et al. Executive dysfunction, awareness deficits and quality of life in patients with cerebral small vessel disease: a structural equation model[J]. Neuropsychology, 2014, 28(2): 247-253.
[4] Bour A, Rasquin S, Limburg M, et al. Depressive symptoms and executive functioning in stroke patients: a follow-up study[J]. Int J Geriatr Psychiatry, 2011, 26(7): 679-686.
[5] Seo E H, Kim H, Lee K H, et al. Altered executive function in pre-mild cognitive impairment[J]. J Alzheimers Dis, 2016, 54(3): 933-940.
[6] Park S H, Sohn M K, Jee S, et al. The characteristics of cognitive impairment and their effects on functional outcome after inpatient rehabilitation in subacute stroke patients[J]. Ann Rehabil Med, 2017, 41(5): 734-742.
[7] Turunen K E, Laari S P, Kauranen T V, et al. Executive impairment is associated with impaired memory performance in working-aged stroke patients[J]. J Int Neuropsychol Soc, 2016, 22(5): 551-560.
[8] Gross A L, Xue Q L, Bandeen-Roche K, et al. Declines and impairment in executive function predict onset of physical frailty[J]. J Gerontol A Biol Sci Med Sci, 2016, 71(12): 1624-1630.
[9] Park Y H, Jang J W, Park S Y, et al. Executive function as a strong predictor of recovery from disability in patients with acute stroke: a preliminary study[J]. J Stroke Cerebrovasc Dis, 2015, 24(3): 554-561.
[10] Yu F, Vock D M, Barclay T R. Executive function: responses to aerobic exercise in Alzheimer's disease.[J]. Geriatr Nurs, 2018, 39(2): 219-224.
[11] Al-Dughmi M, Al-Sharman A, Stevens S, et al. Executive function is associated with off-line motor learning in people with chronic stroke[J]. J Neurol Phys Ther, 2017, 41(2): 101-106.
[12] Jankowska A M, Klimkiewicz R, Kubsik A, et al. Location of the ischemic focus in rehabilitated stroke patients with impairment of executive functions[J]. Adv Clin Exp Med, 2017, 26(5): 767-776.
[13] Hayes S, Donnellan C, Stokes E. Executive dysfunction and balance function post-stroke: a cross-sectional study[J]. Physiotherapy, 2016, 102(1): 64-70.
[14] Toledo J B, Bjerke M, Chen K, et al. Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings[J]. Neurology, 2015, 85(2): 144-153.
[15] Sobreiro M F, Miotto E C, Terroni L, et al. Executive function and depressive symptoms of retardation in nonelderly stroke patients[J]. J Clin Exp Neuropsychol, 2014, 36(6): 636-647.
[16] Lu D, Ren S, Zhang J, et al. Vascular risk factors aggravate cognitive impairment in first-ever young ischaemic stroke patients[J]. Eur J Neurol, 2016, 23(5): 940-947.
[17] Tay S Y, Davison J, Jin N C, et al. Education and executive function mediate engagement in advance care planning in early cognitive impairment[J]. J Am Med Dir Assoc, 2015, 16(11): 957-962.
[18] Hua P, Pan X P, Hu R, et al. Factors related to executive dysfunction after acute infarct[J]. PLoS One, 2014, 9(9): 1-6.
[19] Farrar D C, Mian A Z, Budson A E, et al. Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity[J]. Eur Radiol, 2018, 28(1): 340-347.
[20] Mikell C B, Banks G P, Frey H P, et al. Frontal networks associated with command following after hemorrhagic stroke[J]. Stroke, 2015, 46(1): 49-57.
[21] Cordova C A, Jackson D, Langdon K D, et al. Impaired executive function following ischemic stroke in the rat medial prefrontal cortex[J]. Behav Brain Res, 2014, 258(1): 106-111.
[22] Vataja R, Pohjasvaara T, Mäntylä R, et al. MRI correlates of executive dysfunction in patients with ischaemic stroke[J]. Eur J Neurol, 2003, 10(6): 625-631.
[23] Conti J, Sterr A, Brucki S M, et al. Diversity of approaches in assessment of executive functions in stroke: limited evidence?[J]. eNeurologicalSci, 2015, 1(1): 12-20.
[24] Royall D R, Mahurin R K, Gray K F. Bedside assessment of executive cognitive impairment: the executive interview[J]. J Am Geriatr Soc, 1992, 40(12): 1221-1226.
[25] Dubois B, Slachevsky A, Litvan I, et al. The FAB: a Frontal Assessment Battery at bedside[J]. Neurology, 2000, 55(11): 1621-1626.
[26] Torralva T, Roca M, Gleichgerrcht E, et al. INECO Frontal Screening (IFS): a brief, sensitive, and specific tool to assess executive functions in dementia[J]. J Int Neuropsychol Soc, 2009, 15(5): 777-786.
[27] Ohyama T, Kaga Y, Goto Y, et al. Developmental changes in autonomic emotional response during an executive functional task: a pupillometric study during Wisconsin Card Sorting Test[J]. Brain Dev, 2017, 39(3): 187-195.
[28] Jodzio K, Biechowska D. Wisconsin Card Sorting Test as a measure of executive function impairments in stroke patients[J]. Appl Neuropsychol, 2010, 17(4): 267-277.
[29] Armentano C, Porto C S, Brucki S, et al. Study on the Behavioural Assessment of the Dysexecutive Syndrome (BADS) performance in healthy individuals, mild cognitive impairment and Alzheimer's disease: a preliminary study[J]. Dement Neuropsychol, 2009, 3(2): 101-107.
[30] Hilbert S, Nakagawa T T, Bindl M, et al. The spatial Stroop effect: a comparison of color-word and position-word interference[J]. Psychon Bull Rev, 2014, 21(6): 1509-1515.
[31] Muir R T, Lam B, Honjo K, et al. Trail Making Test elucidates neural substrates of specific poststroke executive dysfunctions[J]. Stroke, 2015, 46(10): 2755-2761.
[32] Tamez E, Myerson J, Morris L, et al. Assessing executive abilities following acute stroke with the trail making test and digit span[J]. Behav Neurol, 2011, 24(3): 177-185.
[33] Leung J L M, Lee G T H, Lam Y H, et al. The use of the Digit Span Test in screening for cognitive impairment in acute medical inpatients[J]. Inter Psychogeriatr, 2011, 23(10): 1569-1574.
[34] Tung L C, Yu W H, Lin G H, et al. Development of a tablet-based symbol digit modalities test for reliably assessing information processing speed in patients with stroke[J]. Disabil Rehabil, 2016, 38(19): 1952-1960.
[35] Poulin V, Korner-Bitensky N, Bherer L, et al. Comparison of two cognitive interventions for adults experiencing executive dysfunction post-stroke: a pilot study[J]. Disabil Rehabil, 2017, 39(1): 1-13.
[36] Cumming T B, Marshall R S, Lazar R M. Stroke, cognitive deficits, and rehabilitation: still an incomplete picture[J]. Int J Stroke, 2013, 8(1): 38-45.
[37] Huang J, McCaskey M A, Yang S, et al. Effects of acupuncture and computer-assisted cognitive training for post-stroke attention deficits: study protocol for a randomized controlled trial[J]. Trials, 2015, 16(2): 546.
[38] Cho H Y, Kim K T, Jung J H. Effects of computer assisted cognitive rehabilitation on brain wave, memory and attention of stroke patients: a randomized control trial[J]. J Phys Ther Sci, 2015, 27(4): 1029-1032.
[39] Kazuta T, Takeda K, Osu R, et al. Transcranial direct current stimulation improves audioverbal memory in stroke patients[J]. Am J Phys Med Rehabil, 2017, 96(8): 565-571.
[40] Yun G J, Chun M H, Kim B R. The effects of transcranial direct-current stimulation on cognition in stroke patients[J]. J Stroke, 2015, 17(3): 354-358.
[41] Jeon S Y, Han S J. Improvement of the working memory and naming by transcranial direct current stimulation[J]. Ann Rehabil Med, 2012, 36(5): 585-595.
[42] Antonenko D, Flöel A. Non-invasive brain stimulation in neurology: transcranial direct current stimulation to enhance cognitive functioning[J]. Nervenarzt, 2016, 87(8): 838-845.
[43] Inoue Y. Repetitive transcranial magnetic stimulation (rTMS) for higher brain function deficits[J]. Brain Nerve, 2016, 68(12): 1459-1470.
[44] 刘远文, 潘翠环, 胡楠, 等. 重复经颅磁刺激治疗脑卒中后执行功能障碍的研究进展[J]. 中国康复理论与实践, 2016, 22(10): 1132-1136.
[44] Liu Y W, Pan C H, Hu N, et al. Advance in repetitive transcranial magnetic stimulation for post-stroke executive impairment (review)[J]. Chin J Rehabil Theory Pract, 2016, 22(10): 1132-1136.
[45] Rektorova I, Megova S, Bares M, et al. Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovascular disease without dementia: a pilot study of seven patients[J]. J Neurol Sci, 2005, 229-230: 157-161.
[46] 刘远文, 方杰, 姜荣荣, 等. 高频重复经颅磁刺激对脑卒中患者执行功能的影响[J]. 中华神经科杂志, 2017, 50(10): 745-750.
[46] Liu Y W, Fang J, Jiang R R, et al. Effects of high frequency repetitive transcranial magnetic stimulation on executive function in patients after stroke[J]. Chin J Neurol, 2017, 50(10): 745-750.
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