《中国康复理论与实践》

《中国康复理论与实践》

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Ski 在神经系统中的作用及机制的研究进展①

周开升1,2，朱彦东1,2，张海鸿2，伍亚民1   

  1. 1.第三军医大学大坪医院野战外科研究所三室，创伤、烧伤与复合伤国家重点实验室，重庆市400042；2.兰州大学第二医院骨科，甘肃兰州市730030。
  • 出版日期:2016-07-25 发布日期:2016-09-22

Role and Mechanism of Ski in Nervous System (review)

ZHOU Kai-sheng1,2, ZHU Yan-dong1,2, ZHANG Hai-hong2, WU Ya-min1   

  1. 1. State Key Laboratory of Trauma, Burns and Combined Injury, the Third Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China; 2. Department of Orthopedics, Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China
  • Published:2016-07-25 Online:2016-09-22

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摘要： Ski 作为一种进化保守蛋白，在不同物种中广泛参与并调节多种细胞的增殖及分化过程。Ski 在胚胎神经系统发育、中枢及周围神经系统病变中发挥一定作用，可能涉及转化生长因子-β 及其超家族成员之一骨形态形成蛋白信号通路。

关键词: ski, 神经系统, 机制, 综述

Abstract: Ski, as an evolutionary conserved protein, is widely involoved in the proliferation and differentiation of many kinds of cells in different species. Ski also plays an irreplaceable role in many physiological and pathological processes of nervous system, including embryonic nervous system development, central and peripheral nervous system diseases, and so on, which may be assiciated with the signal pathways of transforming growth factor-beta and another family member bone morphogenetic protein.

Key words: ski, nervous system, mechanism, review