《中国康复理论与实践》

《中国康复理论与实践》

• 临床研究 • 上一篇    下一篇

磁共振弥散张量成像评价脑梗死视辐射损伤的研究①

陆强彬1a，朱祖福1a，姜岐涛1b，沈丽萍1c，张慧萍1a   

  1. 1. 东南大学医学院附属江阴医院，a. 神经内科；b. 影像科；c. 眼科，江苏江阴市214400。
  • 出版日期:2016-07-25 发布日期:2016-09-22

Evaluation for Injury in Optic Radiation after Ischemic Stroke with Diffusion Tensor Imaging

LU Qiang-bin1a, ZHU Zu-fu1a, JIANG Qi-tao1b, SHEN Li-ping1c, ZHANG Hui-ping1a   

  1. 1. a. Department of Neurology; b. Department of Imaging; c. Department of Ophthalmology, Jiangyin Hospital Affiliated to Southeast University Medical College, Jiangyin, Jiangsu 214400, China
  • Published:2016-07-25 Online:2016-09-22

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摘要： 目的探讨磁共振弥散张量成像技术(DTI)评价脑梗死视辐射损伤的价值。方法2014 年9 月~2015 年9 月，21 例单侧脑梗死伴视野缺损患者行DTI检查，测量患侧及健侧视辐射不同时期各向异性分数(FA)及表观扩散系数(ADC)，同期测量双眼视野平均缺损(MD)，分析FA、ADC与MD的相关性。结果发病后24 h 内(t=2.38, P<0.05)、第1 周(t=15.60, P<0.01)、第4 周(t=19.13,P<0.01)时患侧FA均低于健侧；24 h 内(t=10.13, P<0.01)及第1 周(t=6.06, P<0.01)患侧ADC明显低于健侧。患侧第1 周(r=0.581, P<0.01)、第4 周(r=0.703, P<0.01) FA与同期MD呈正相关；患侧24 h 内ADC与同期MD呈正相关(r=0.519, P<0.05)。患侧第1 周(r=0.525, P<0.05)、第4 周(r=0.762, P<0.01) FA与6个月时MD均呈正相关。结论DTI可用于评价脑梗死后视辐射损伤。

关键词: 脑梗死, 视辐射, 弥散张量成像, 视野缺损, 各向异性分数, 表观弥散系数

Abstract: Objective To evaluate the injury of optic radiation after ischemic stroke with diffusion tensor imaging (DTI). Methods From September, 2014 to September, 2015, twenty-one ischemic stroke inpatients with visual field defects were tested with DTI, and measured the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of both sides in different time. The correlation of FA and ADC to visual field mean defect (MD) in the same time was analyzed. Results The FA of affected sides was lower than that of healthy sides twenty-four hours (t=2.38, P<0.05), one week (t=15.60, P<0.01) and four weeks (t=19.13, P<0.01) after stroke, and the ADC was also lower twenty-four hours (t=10.13, P<0.01) and one week (t=6.06, P<0.01) after stroke. The FA correlated with MD one (r=0.581, P<0.01) and four weeks (r= 0.703, P<0.01) after stroke, and the ADC correlated with MD twenty-four hours after stroke (r=0.519, P<0.05). The FA of one (r=0.525, P< 0.05) and four weeks (r=0.762, P<0.01) after stroke correlated with MD six months after stroke. Conclusion DTI can be used to evaluate the injury of optic radiation after ischemic stroke.

Key words: ischemic stroke, optic radiation, diffusion tensor imaging, visual field defects, fractional anisotropy, apparent diffusion coefficient