《中国康复理论与实践》

《中国康复理论与实践》

• 临床研究 • 上一篇    下一篇

完全性脊髓损伤后血清S-100β 蛋白浓度的变化①

王玉明1,2，朱致敏3，车俊艳1,2，李慧兰1,2，马科1,2，宫慧明1,2，陈惠1,2，钟华3，杨明亮1,2，杜良杰1,2   

  1. 1. 中国康复研究中心北京博爱医院，北京市100068；2. 首都医科大学康复医学院，北京市100068；3. 广东省廉江市人民医院，广东廉江市524400。
  • 出版日期:2016-07-25 发布日期:2016-09-22

Changes of Serum S-100β Protein after Complete Spinal Cord Injury

WANG Yu- ming1,2, ZHU Zhi- min3, CHE Jun- yan1,2, LI Hui- lan1,2, MA Ke1,2, GONG Hui- ming1,2, CHEN Hui1,2, ZHONG Hua3, YANG Ming-liang1,2, DU Liang-jie1,2   

  1. 1. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China; 2. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China; 3. The Lianjiang People's Hospital, Lianjiang, Guangdong 524400, China
  • Published:2016-07-25 Online:2016-09-22

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摘要： 目的评价S-100β 蛋白能否成为创伤性脊髓损伤的血清标记物。方法2013 年6 月~2014 年10 月，选取完全性脊髓损伤患者24 例，分别在损伤后1 周、3 个月、6 个月抽血，采用酶联免疫吸附法测定血清中S-100β 蛋白浓度，以10 名健康人血清作为正常对照。结果S-100β 蛋白血清浓度在损伤后1 周、3 个月时显著升高(Z>4.273, P<0.001)。结论S-100β 蛋白血清浓度升高可能有助于评估完全性脊髓损伤后早期的组织损伤。

关键词: 脊髓损伤；S-100&beta, 蛋白；血清；生物标记物

Abstract: Objective To evaluate whether S-100β protein could be a serum marker for traumatic spinal cord injury (SCI). Methods From June, 2013 to October, 2014, 24 patients with complete SCI were measured the serum S- 100β protein concentrations with enzyme- linked immunosorbent assay, one week, three and six months after SCI. Serum from ten healthy persons was as normal control. Results The serum S-100β protein concentrations increased one week and 3 months after SCI (Z>4.273, P<0.001). Conclusion The increase of serum S-100β protein may help assessing early impairment after complete SCI.

Key words: spinal cord injury, S-100&beta, protein, serum, biomarker