《中国康复理论与实践》

《中国康复理论与实践》

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瞬时受体电位A1 通道在神经病理性疼痛中的研究进展①

张林净1，刘若卓1,2，于生元1   

  1. 1. 中国人民解放军总医院神经内科，北京市100853；2. 中国人民解放军总医院海南分院神经内科，海南三亚市572013。
  • 出版日期:2016-08-25 发布日期:2016-09-22

Transient Receptor Potential Ankyrin 1 Channel in Neuropathic Pain (review)

ZHANG Lin-jing1, LIU Ruo-zhuo1,2, YU Sheng-yuan1   

  1. 1. Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China; 2. Department of Neurology, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan 572013, China
  • Published:2016-08-25 Online:2016-09-22

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摘要： 瞬时受体电位A1(TRPA1)是瞬时受体电位大家族中的一员，主要分布在初级感觉神经元上，如三叉神经节、迷走神经节及背根神经节。神经病理性疼痛最常见的原因是周围神经损伤、糖尿病以及化疗药物所致。神经病理性疼痛过程中产生的大量氧化、硝化应激产物作用于TRPA1，产生急性伤害感受刺激、异常感觉痛以及多种刺激超敏状态。TRPA1 特异性拮抗剂有望用于神经病理性疼痛的治疗。本文总结了TRPA1 在神经病理性疼痛中的研究进展。

关键词: 瞬时受体电位A1, 神经病理性疼痛, 氧化性应激, 硝化应激, 综述

Abstract: Transient receptor potential ankyrin 1 (TRPA1) is a family member of the transient receptor potential (TRPs). It is primarily localized to a subpopulation of primary sensory neurons, such as trigeminus, vagus and dorsal root ganglia. Neuropathic pain is often caused by peripheral nerve injury, diabetes and chemotherapeutics. A large of oxidative/nitrative stress products are produced during neuropathic pain, which cause acute nociception, allodynia, and hyperalgesia. TRPA1 antagonists may be beneficial in the treatment of neuropathic pain. Here, the role of TRPA1 in neuropathic pain is summarized.

Key words: transient receptor potential ankyrin 1, neuropathic pain, oxidative stress, nitrative stress, review