《中国康复理论与实践》

《中国康复理论与实践》

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癫痫与抑郁障碍共患关联机制的研究进展①

赵爽1，邓佳卉2，徐志卿3，张胜昌4   

  1. 1. 右江民族医学院病理生理学教研室，广西高校桂西地区高发病防治研究重点实验室，广西百色市533000；2. 首都医科大学三博脑科医院，癫痫病临床医学研究北京市重点实验室，北京市100093；3. 首都医科大学神经生物学系，北京市脑重大疾病研究院，北京市100069；4. 广西中医药大学，广西南宁市530001。
  • 出版日期:2016-09-25 发布日期:2016-12-05

Relation Mechanism of Epilepsy and Depressive Disorder (review)

ZHAO Shuang1, DENG Jia-hui2, XU Zhi-qing3, ZHANG Sheng-chang4   

  1. 1. Department of Pathophysiology, Youjiang Medical College for Nationalities, Key Laboratories of the West Guangxi Endemic Diseases Prevention and Treatment in Guangxi Province, Baise, Guangxi 533000, China; 2. Sanbo Brain Hospital, Capital Medical University; Beijing Key Laboratory of Epilepsy, Epilepsy Center of Beijing Institute for Brain Disorders, Beijing 100093, China; 3. Department of Neurobiology, Capital Medical University, Beijing Institute for Brain Disorders, Beijing 100069, China; 4. Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530001, China
  • Published:2016-09-25 Online:2016-12-05

PDF (PC)

摘要： 抑郁症是癫痫最常见的共患精神障碍，提示癫痫与抑郁障碍可能存在很多共同的发病机制，如神经递质、神经肽及其受体、神经胶质细胞、免疫介质、神经信号转导通路、突触可塑性与神经再生等。

关键词: 癫痫, 抑郁障碍, 关联机制, 综述

Abstract: Depression is the most common mental disorder in epilepsy, which means that they maybe have some common pathogenesis. This paper discussed the biological relation mechanism, such as neurotransmitter, neuropeptide and its receptor, glial cell, immune-mediators, nerve signal transduction pathway, synaptic plasticity and nerve regeneration.

Key words: epilepsy, depressive disorder, relation mechanism, review