《中国康复理论与实践》

《中国康复理论与实践》

• 综述 • 上一篇    下一篇

核因子κB在运动防治慢性阻塞性肺疾病患者骨骼肌萎缩中的作用机制①

吴卫兵1 ，刘景新1，刘晓丹2，王振伟3，严隽陶2   

  1. 1. 上海体育学院，运动健身科技省部共建教育部重点实验室，上海市200438；2. 上海中医药大学康复医学院，上海市201203；3.上海岳阳中西医结合医院呼吸科，上海市200437。
  • 出版日期:2016-10-25 发布日期:2016-12-05

Mechanism of Nuclear Factor-κB in Skeletal Muscle Atrophy during Prevention and Treatment of Exercise in Patients with Chronic Obstructive Pulmonary Disease (review)

WU Wei-bing1, LIU Jing-xin1, LIU Xiao-dan2, WANG Zhen-wei3, YAN Jun-tao2   

  1. 1. Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China; 2. School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 3. Department of Respiratory Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200437, China
  • Published:2016-10-25 Online:2016-12-05

PDF (PC)

摘要： 慢阻塞性肺疾病(COPD)具有明显的肺外损伤效应，可引起呼吸肌和外周骨骼肌的萎缩，严重影响患者呼吸功能和生活质量，其中核因子κB(NF-κB)过度激活被认为是COPD患者骨骼肌萎缩的一种重要因素。本文从NF-κB激活与COPD患者骨骼肌蛋白降解和骨骼肌细胞再生之间关系，分析NF-κB在COPD患者骨骼肌萎缩中的作用及运动对COPD骨骼肌NF-κB通路的影响。

关键词: 慢性阻塞性肺疾病；骨骼肌萎缩；运动；核因子&kappa, B；综述

Abstract: Chronic obstructive pulmonary (COPD) has significant extra pulmonary effects, which could induce atrophy of peripheral skeletal muscle and respiratory muscles, and significantly influence the respiratory function and quality of life. Muscle nuclear factor (NF)-κB activation plays a key role in the skeletal muscle atrophy. This article discussed the potential mechanisms on how NF-κB signaling pathway increasing protein breakdown and reducing muscle regeneration. On this basis, we explored the role of NF-κB in skeletal muscle atrophy in patients with COPD during exercise.

Key words: chronic obstructive pulmonary disease, skeletal muscle atrophy, exercise, nuclear factor κB, review