《中国康复理论与实践》

《中国康复理论与实践》

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脑白质病变病理学及影像学的研究进展①

王金芳1,2，梁莹3，陈红艳1，冯丽1，叶娜1，王诗男1，张玉梅1   

  1. 1. 首都医科大学附属北京天坛医院神经病学中心，北京市100050；2. 长江航运总医院⋅ 武汉脑科医院神经内科，湖北武汉市430010；3. 首都医科大学，北京市100069。
  • 出版日期:2016-10-25 发布日期:2016-12-05

Advance in Pathology and Imaging Studies of Leukoaraiosis (review)

WANG Jin-fang1,2, LIANG Ying3, CHEN Hong-yan1, FENG Li1, YE Na1, WANG Shi-nan1, ZHANG Yu-mei1   

  1. 1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050; 2. Department of Neurology, General Hospital of The Yang Tze River Shipping, Wuhan Brain Hospital, Wuhan, Hubei 430010, China; 3. Capital Medical University, Beijing 100069, China
  • Published:2016-10-25 Online:2016-12-05

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摘要： 脑白质病变具有重要的临床意义，但其病理生理学机制尚不十分清楚。本文介绍脑白质病变的临床表现、病理学与影像学研究进展及目前研究的不足等内容，加深对脑白质病变病理表现的认识，提高对脑白质病变早期可逆性病理改变的识别，以便临床早期干预，预防痴呆的发生。

关键词: 脑白质病变, 血管性认知功能障碍, 多模态影像, 病理, 综述

Abstract: Leukoaraiosis (LA) has important clinical significance; however, the neurobiological mechanism was still unclear. In this paper, we reviewed literatures about the clinical symptoms, pathology and imaging of LA in order to improve the understanding of the pathologic mechanism, recognize the reversible pathological change in the earliest stage, which can help to prevent dementia.

Key words: leukoaraiosis, vascular cognitive impairment, multimodal images, pathologic mechanism, review