小胶质细胞自噬在缺血性脑卒中中作用的研究进展

doi:10.3969/j.issn.1006-9771.2016.12.011

《中国康复理论与实践》 ›› 2016, Vol. 22 ›› Issue (12): 1416-1415.doi: 10.3969/j.issn.1006-9771.2016.12.011

小胶质细胞自噬在缺血性脑卒中中作用的研究进展

王栋，侯博儒，杨文桢，康军林，任海军

兰州大学第二医院神经外科，甘肃兰州市 730000。

收稿日期:2016-09-09 出版日期:2016-12-25 发布日期:2017-01-15
通讯作者: 任海军(1962-)，男，汉族，甘肃兰州市人，主任医师、教授，硕士研究生导师，主要研究方向：重型颅脑损伤。E-mail: baiyunguan@hotmail.com。
作者简介:王栋(1989-)，男，汉族，陕西西安市人，硕士研究生，主要研究方向：重型颅脑损伤及脑血管病。
基金资助:
1.甘肃省自然科学基金面上基金项目(No. 1506RJZA222)；2.兰州市科技局基金项目(No.2015-2-55)。

Role of Microglia Autophagy in Ischemic Stroke (review)

WANG Dong, HOU Bo-ru, YANG Wen-zhen, KANG Jun-lin, REN Hai-jun

Department of Neurosurgery, Second Hospital Affiliated Lanzhou University, Lanzhou, Gansu 730000, China

Received:2016-09-09 Published:2016-12-25 Online:2017-01-15
Contact: REN Hai-jun. E-mail: baiyunguan@hotmail.com

摘要/Abstract

摘要： 自噬在调控缺血性脑卒中后小胶质细胞活化及其介导的炎症反应中发挥重要作用。缺血性脑卒中后，小胶质细胞自噬与其介导神经炎症的相互作用具体调节机制十分复杂，涉及众多分子参与。小胶质细胞活化的受体及其相关物质可能是参与调控小胶质细胞自噬的潜在机制。自噬抑制剂和小胶质细胞受体靶向治疗可能会为临床治疗缺血性脑卒中提供新策略。本文就缺血性脑卒中后小胶质细胞自噬的相关研究进展进行综述。

关键词: 缺血性脑卒中, 小胶质细胞, 自噬, 综述

Abstract: Autophagy plays an important role in the regulation of activation and inflammation of microglia after ischemic stroke. The interaction between autophagy of microglia and the inflammation mediated by microglia after ischemic stroke was complex and a large number of molecules were involved. The receptors of microglia activation and related substances may be possible mechanism in the regulation of microglia autophagy. Autophagy inhibitors and microglia receptor targeting therapy may provide new strategies for the clinical treatment of ischemic stroke. This paper summarized the progress of microglia autophagy after ischemic stroke.

Key words: ischemic stroke, microglia, autophagy, review

中图分类号:

R743.3

王栋，侯博儒，杨文桢，康军林，任海军. 小胶质细胞自噬在缺血性脑卒中中作用的研究进展[J]. 《中国康复理论与实践》, 2016, 22(12): 1416-1415.

WANG Dong, HOU Bo-ru, YANG Wen-zhen, KANG Jun-lin, REN Hai-jun. Role of Microglia Autophagy in Ischemic Stroke (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2016, 22(12): 1416-1415.

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小胶质细胞自噬在缺血性脑卒中中作用的研究进展

Role of Microglia Autophagy in Ischemic Stroke (review)

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