《中国康复理论与实践》

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (3): 266-268.doi: 10.3969/j.issn.1006-9771.2017.00.001

• 基础研究 • 上一篇    下一篇

脊髓损伤后恒河猴双下肢体重支撑的改变

赵文1, 魏瑞晗2, 饶家声2, 赵璨2, 田鹏宇2, 周侠2, 季润3, 李立峰3, 杨朝阳1,2, 李晓光1,2   

  1. 1.首都医科大学神经生物学系,北京市 100069;
    2.北京航空航天大学生物材料和神经再生北京市实验室,生物医学工程学院,北京市 100191;
    3.国家康复辅具研究中心人体生物力学实验室,北京市 100176
  • 收稿日期:2017-11-13 修回日期:2017-12-07 出版日期:2018-03-25 发布日期:2018-03-27
  • 通讯作者: 李晓光。E-mail: lxgchina@sina.com
  • 作者简介:赵文(1990-),女,汉族,河北邢台市人,硕士,技师,主要研究方向：应用组织工程学方法修复脊髓损伤的行为学评价。通讯作者：李晓光(1959-),男,吉林长春市人,博士,教授,主要研究方向：应用组织工程学的方法修复神经系统损伤的研究。
  • 基金资助:
    1.国家重点研发计划(No. 2017YFC1104002; No. 2017YFC1104001); 2.国家自然科学基金面上项目(No. 31670988; No. 31771053); 3.国家自然科学基金应急管理项目(No. 31650001); 4.国家自然科学基金国际(地区)合作与交流项目(No. 31320103903); 5.高等学校全国优秀博士学位论文作者专项资金资助项目(No. 201356); 6.国家自然科学基金重点项目(No. 31730030); 7.北京市科技计划(No. Z171100002217066)

Impairment of Weight Support of Lower Limbs after Spinal Cord Hemi-section in Rhesus Monkeys

ZHAO Wen1, WEI Rui-han2, RAO Jia-sheng2, ZHAO Can2, TIAN Peng-yu2, ZHOU Xia2, JI Run3, LI Li-feng3, YANG Zhao-yang1,2, LI Xiao-guang1,2   

  1. 1. Department of Neurobiology, Capital Medical University, Beijing 100069, China;
    2. Beijing Key Laboratory for Biomaterials and Neural Regeneration, Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;
    3. Human Biomechanics Laboratory, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China
  • Received:2017-11-13 Revised:2017-12-07 Published:2018-03-25 Online:2018-03-27
  • Contact: LI Xiao-guang. E-mail: lxgchina@sina.com
  • Supported by:
    Supported by National Key Research and Development Program (No. 2017YFC1104002; No. 2017YFC1104001); National Natural Science Foundation of China, Key Program (No. 31730030), General Program (No. 31670988; No. 31771053), Emergency Management Program (No. 31650001), Projects of International Cooperation and Exchanges (No. 31320103903); Special Funds for the Authors of Excellent Doctoral Dissertations of Universities and Colleges (No. 201356); and Beijing Science and Technology Program (No. Z171100002217066)

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摘要： 目的 观察脊髓损伤对肢体承重能力的影响,揭示脊髓损伤后下肢承重能力随时间的变化规律。方法 6只成年雌性恒河猴行T7-9右半侧1 cm切除术。采用Foot-Scan系统测量恒河猴脊髓损伤前,损伤后6周、12周时双下肢足底压力百分比。结果 损伤前,双下肢足底压力百分比无显著性差异(Z=-1.330, P>0.05);损伤后6周和12周,左下肢足底压力百分比显著高于右下肢(Z>4.783, P<0.001)。损伤前后,右下肢足底压力百分比呈现逐步显著下降趋势(Z=3.191, P<0.001)。结论 脊髓损伤后,损伤侧下肢承重能力严重缺失,不经干预则呈持续下降趋势。

关键词: 脊髓损伤, 下肢, 体重, 支撑, 恒河猴

Abstract: Objective To observe the influence of spinal cord injury on lower limbs weight support capacity, and the changes with time. Methods Six adult female rhesus monkeys with thoracic (T7-9) right spinal cord hemi-section were measured the plantar pressure ratio of both lower limbs with Foot-Scan system before, and six and twelve weeks after operation. Results There was no statistical difference between both sides of limbs before operation (Z=-1.330, P>0.05), while the plantar pressure ratio was more on the left limbs six and twelve weeks after operation (Z>4.783, P<0.001). The plantar pressure ratio of right lower limb became less and less during observation (Z=3.191, P<0.001).Conclusion The weight support capacity of affected limbs is injured after spinal cord hemi-section in monkeys, and would become worse without intervention.

Key words: spinal cord injury, lower limbs, body weight, support, rhesus monkeys

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