《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (4): 446-448.doi: 10.3969/j.issn.1006-9771.2017.04.018

• 临床研究 • 上一篇    下一篇

选择性β1受体阻滞剂对高血压患者运动耐力的影响

李寿霖1,2a,张焱1,2a,刘杰1,2a,杨威1,2a,刘立君1,2a,郑志昌1,2a,林伟1,2a,王晓荣1,2a,王国栋1,2a,封丽红1,2a,陈思远1,2a,杨祖福1,2b   

  1. 1.首都医科大学康复医学院,北京市100068;
    2.中国康复研究中心北京博爱医院,a.心血管内科;
    b.中医康复科,北京市100068。
  • 收稿日期:2016-05-20 出版日期:2017-04-05 发布日期:2017-05-17
  • 作者简介:李寿霖(1963-),男,山东海阳市人,医学博士,主任医师,主要研究方向:心血管疾病的康复。E-mail: shoulinli63@163.com。
  • 基金资助:
    1.教育部人文社会科学研究一般项目(No.13XJC880010);2.重庆师范大学基金项目(No.12XWB045)。

Effect of Selective beta-1 Adrenoreceptor Blocker on Exercise Tolerance in Patients with Hypertention 

LI Shou-lin1,2a, ZHANG Yan1,2a, LIU Jie1,2a, YANG Wei1,2a, LIU Li-jun1,2a, ZHENG Zhi-chang1,2a, LIN Wei1,2a, WANG Xiao-rong1,2a, WANG Guo-dong1,2a, FENG Li-hong1,2a, CHEN Si-yuan1,2a, YANG Zu-fu1,2b   

  1. 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China;
    2. a. Department of Cardiovasology;b. Department of Traditional Chinese Medicine Rehabilitation, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • Received:2016-05-20 Published:2017-04-05 Online:2017-05-17
  • Contact: LI Shou-lin. E-mail: shoulinli63@163.com

摘要: 目的  探讨选择性β1受体阻滞剂对高血压患者运动耐力的影响。方法  2015年5月至2016年5月,72例高血压患者按照是否服用选择性β1受体阻滞剂分为两组。A组(n=35)行心肺运动试验前2周服用选择性β1受体阻滞剂,B组(n=37)行心肺运动试验前2周未曾服用任何β受体阻滞剂。两组均行心肺运动试验,比较两组间运动耐力。结果  A组最大收缩压、峰值心率、运动后1 min时心率(HR1)和最大心率血压乘积均低于B组(t>2.012, P<0.05),而HR1恢复值高于B组(t=2.100, P<0.05)。两组间峰值功率及峰值摄氧量均无显著性差异(t<0.689, P>0.05)。结论  选择性β1受体阻滞剂可降低心肌耗氧量,改善迷走神经张力,并未降低高血压患者的运动耐力。

关键词: 高血压病, β1受体阻滞剂, 心肺运动试验

Abstract: Objective To explore the effect of selective beta-1 adrenoreceptor blocker on exercise tolerance in patients with hypertension. Methods From May, 2015 to May, 2016, 72 patients with hypertension were divided into two groups, according to whether taking the selective beta-1 receptor blocker. Group A (n=35) took the selective beta-1 receptor blocker two weeks before cardiopulmonary exercise, while group B (n=37) did not take anything at the same time. The exercise tolerance was compared between two groups. Results The maximal systolic blood pressure, peak heart rate, one-minute heart rate after exercise (HR1) and rate-pressure product were lower in group A than in group B (t>2.012, P<0.05), however, the recovery value of HR1 was higher in group A than in group B (t=2.100, P<0.05). There was no difference in both peak power and peak oxygen uptake between two groups (t<0.689, P>0.05). Conclusion The selective beta-1 adrenoreceptor blocker could reduce myocardial oxygen consumption, and improve vagus nerve activity, but did not reduce exercise tolerance in patients with hypertension.

Key words: hypertension, selective beta-1 adrenoreceptor blocker, cardiopulmonary exercise testing

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