海马亚区磁共振成像T2信号评估遗忘型轻度认知障碍的可行性

doi:10.3969/j.issn.1006-9771.2017.05.018

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (5): 575-579.doi: 10.3969/j.issn.1006-9771.2017.05.018

海马亚区磁共振成像T₂信号评估遗忘型轻度认知障碍的可行性

张小洁, 曹志宏, 罗一烽, 刘瑜², 吴立伟, 单海荣, 刘怡文, 李月峰³, 王冬青³

1.江苏大学附属宜兴医院,a.神经内科;b.放射科,江苏无锡市 214200;
2.宜兴市第二人民医院放射科,江苏无锡市 214200;
3.江苏大学附属医院影像科,江苏镇江市 212000。

收稿日期:2016-06-23 修回日期:2016-07-19 出版日期:2017-05-25 发布日期:2017-05-24
通讯作者: 罗一烽,男,博士后,主治医师。E-mail: luoyifeng1207@163.com。
作者简介:张小洁(1982-),女,汉族,江苏宜兴市人,硕士研究生,主治医师,主要研究方向：神经影像学。
基金资助:
1.江苏省卫计委面上项目(No.H201656); 2.无锡市科技计划项目(No.CSZ0N1632; No.CSEW1N1111); 3.无锡市卫生计生科技成果和适宜技术推广项目(No.T201601); 4.无锡市卫计委科研项目(No.Z201610; No.ML201320)

Application of Hippocampal Subfield Magnetic Resonance Imaging T₂ Signal Intensity for Amnestic Mild Cognitive Impairment

ZHANG Xiao-jie, CAO Zhi-hong, LUO Yi-feng, LIU Yu², WU Li-wei, SHAN Hai-rong, LIU Yi-wen, LI Yue-feng³, WANG Dong-qing³

1. a. Department of Neurology; b. Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China;
2. Department of Radiology, the Yixing Second People's Hospital, Wuxi, Jiangsu 214200, China;
3. Department of Radiology, the Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, China

Received:2016-06-23 Revised:2016-07-19 Published:2017-05-25 Online:2017-05-24
Contact: LUO Yi-feng. E-mail: luoyifeng1207@163.com

摘要/Abstract

摘要： 目的观察认知训练前后遗忘型轻度认知障碍(aMCI)患者海马亚区磁共振成像(MRI) T₂信号的变化,为aMCI的临床早期诊疗提供影像学帮助。方法 2014年10月至2015年8月,aMCI患者40例随机均分为认知训练组和沟通组,另选老年健康志愿者20例作为对照组。认知训练组接受认知训练,沟通组采用普通谈话沟通,共治疗3个月。治疗前后采用快速自旋回波T₂序列进行MRI检查,于工作站中勾画海马各亚区,测量T₂信号强度,对T₂信号强度与简易精神状态检查(MMSE)评分进行相关性分析。结果治疗前,与对照组比较,认知训练组和沟通组双侧海马头部T₂信号强度增高(P<0.05),认知训练组与沟通组之间无显著性差异(P>0.05)。治疗后,认知训练组左侧海马头部T₂信号强度下降,与对照组无显著性差异(P>0.05),低于沟通组(P<0.05);认知训练组MMSE评分较治疗前升高(t=3.07, P<0.05)。治疗前后,认知训练组MMSE评分与左侧海马头部T₂信号强度均呈负相关(r=-0.61, r=-0.54, P<0.05)。双侧体、尾部T₂信号强度治疗前后各组间均无显著性差异(t<0.62, P>0.05)。结论左侧海马头部MRI T₂信号强度可反映aMCI颅内的病理生理改变,可用于评估认知训练效果,也可作为aMCI早期诊疗的辅助指标。

关键词: 轻度认知障碍, 海马, 磁共振成像, T2加权信号, 评定, 诊断

Abstract: Objective To apply the MRI T₂ signal intensity of hippocampal subfield in patients with amnestic mild cognitive impairment (aMCI) as early imageology. Methods From October, 2014 to August, 2015, 20 aMCI patients accepted cognitive training (training group), 20 aMCI patients accepted speech communication (speech group), and 20 age- and gender-matched healthy old people (control group) were scanned with MRI using FSE-T₂ sequence. The margin of hippocampal subfields were outlined manually for each side to measure the T₂ signal intensity. The correlation between hippocampal T₂ signal intensity and the scores of Mini-Mental State Examinatlon (MMSE) was analyzed in the training group. Results Before treatment, T₂ signal intensity in the bilateral hippocampal head was significantly high in the aMCI patients compared with that in the control group (P<0.05). After treatment, T₂ signal intensity in left hippocampal head decreased in the training group compared with that in the speech group (P<0.05), similar to the control group (P>0.05). There was negative correlation between left hippocampal head's T₂ signal intensity and the scores of MMSE in the training group before and after treatment (r=-0.61, r=-0.54, P<0.05). Conclusion The T₂ signal intensity in left hippocampal head may respond to the cognitive function in patients with aMCI in the early stage, that could be used for diagnosis and evaluation in clinic.

Key words: mild cognitive impairment, hippocampus, magnetic resonance imaging, T2-weighted signal, evaluation, diagnosis

中图分类号:

R749.1

张小洁, 曹志宏, 罗一烽, 刘瑜, 吴立伟, 单海荣, 刘怡文, 李月峰, 王冬青. 海马亚区磁共振成像T₂信号评估遗忘型轻度认知障碍的可行性[J]. 《中国康复理论与实践》, 2017, 23(5): 575-579.

ZHANG Xiao-jie, CAO Zhi-hong, LUO Yi-feng, LIU Yu, WU Li-wei, SHAN Hai-rong, LIU Yi-wen, LI Yue-feng, WANG Dong-qing. Application of Hippocampal Subfield Magnetic Resonance Imaging T₂ Signal Intensity for Amnestic Mild Cognitive Impairment[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(5): 575-579.

参考文献

[1] Albert MS, Dekosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheime's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J]. Alzheimers Dement, 2011, 7(3): 270-279.
[2] Rosenberg PB, Lyketsos C. Mild cognitive impairment: searching for the prodrome of Alzheimer's disease [J]. World Psychiatry, 2008, 7(2): 72-78.
[3] 于洋,尹昌浩. 轻度认知障碍患者脑结构与功能网络变化的研究进展[J]. 中国康复理论与实践. 2015, 21(6): 653-656.
[4] Apostolova LG, Green AE, Babakchanian S, et al. Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease [J]. Alzheimer Dis Assoc Disord, 2012, 26(1): 17-27.
[5] Hanamiya M, Korogi Y, Kakeda S, et al. Partial loss of hippocampal striation in medial temporal lobe epilepsy: pilot evaluation with high-spatial-resolution T 2 -weighted MR imaging at 3.0 T [J]. Radiology, 2009, 251(3): 873-881.
[6] Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome [J]. Arch Neurol, 1999, 56(3): 303-308.
[7] Gates N, Valenzuela M. Cognitive exercise and its role in cognitive function in older adults [J]. Curr Psychiatry Rep, 2010, 12(1): 20-27.
[8] Martin SB, Smith CD, Collins HR, et al. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment [J]. Neurobio Aging, 2010, 31(7): 1099-1106.
[9] Malykhin NV, Bouchard TP, Ogilvie CJ, et al. Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tail [J]. Psychiatry Res, 2007, 155(2): 155-165.
[10] Long Z, Jiang YM, Li XR, et al. Vulnerability of welders to manganese exposure–a neuroimaging study [J]. Neurotoxicology, 2014, 45: 285-292.
[11] Sonkusare SK, Kaul CL, Ramarao P. Dementia of Alzheimer's disease and other neurodegenerative disorders–memantine, a new hope [J]. Pharmacol Res, 2005, 51(1): 1-17.
[12] Selkoe DJ. Resolving controversies on the path to Alzheimer's therapeutics [J]. Nat Med, 2011, 17(9): 1060-1065.
[13] Smith AD. Why are drug trials in Alzheimer's disease failing? [J]. Lancet, 2010, 376(9751): 1466.
[14] Zhu WZ, Zhong WD, Wang W, et al. Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease [J]. Radiology, 2009, 253(2): 497-504.
[15] House MJ, St PT, Foster JK, et al. Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss [J]. AJNR Am J Neuroradiol, 2006, 27(2): 430-439.
[16] Schenck JF, Zimmerman EA, Li Z, et al. High-field magnetic resonance imaging of brain iron in Alzheimer disease [J]. Top Magn Reson Imaging, 2006, 17(1): 41-50.
[17] Ramani A, Jensen JH, Helpern JA. Quantitative MR imaging in Alzheimer disease [J]. Radiology, 2006, 241(1): 26-44.
[18] Coan AC, Kobayashi E, Lopes-Cendes I, et al. Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy [J]. Braz J Med Biol Res, 2004, 37(6): 827-832.
[19] 杜绪仓,王泽忠,鱼博浪. 海马结构的磁共振信号测量[J]. 实用放射学杂志, 2001, 17(5): 336-338.
[20] Fazekas F, Chawluk JB, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging [J]. AJR Am J Roentgenol, 1987, 149(2): 351-356.
[21] Greene SJ, Killiany RJ. Hippocampal subregions are differentially affected in the progression to Alzheimer's disease [J]. Anat Rec (Hoboken), 2012, 295(1): 132-140.
[22] Hanseeuw BJ, Van Leemput K, Kavec M, et al. Mild cognitive impairment: differential atrophy in the hippocampal subfields [J]. Am J Neuroradiol, 2011, 32(9): 1658-1661.
[23] 牛轶瑄,谭纪平,管锦群. 认知训练治疗阿尔茨海默病的疗效观察[J]. 中华物理医学与康复杂志, 2011, 33(1): 52-55.
[24] Kristofikova Z, Stastny F, Bubenikova V, et al. Age- and sex-dependent laterality of rat hippocampal cholinergic system in relation to animal models of neurodevelopmental and neurodegenerative disorders [J]. Neurochem Res, 2004, 29(4): 671-680.
[25] Kristofikova Z, Kozmikova I, Hovorkova P, et al. Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia [J]. Neurochem Int, 2008, 53(5): 118-125.
[26] Shi F, Liu B, Zhou Y, et al. Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies [J]. Hippocampus, 2009, 19(11): 1055-1064.

海马亚区磁共振成像T₂信号评估遗忘型轻度认知障碍的可行性

Application of Hippocampal Subfield Magnetic Resonance Imaging T₂ Signal Intensity for Amnestic Mild Cognitive Impairment

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	袁媛, 周红俊, 丛欣莹, 刘根林, 卫波, 郑樱, 郝春霞, 张缨, 王一吉, 康海琼, 逯晓蕾, 蒙倩茹. 创伤性颈脊髓损伤程度与磁共振成像的关系[J]. 《中国康复理论与实践》, 2023, 29(6): 725-730.
[2]	程斯曼, 辛榕, 赵燕, 刘庆余, 谢加乐, 刘鹏, 王朴. 重复经颅磁刺激改善脑卒中功能障碍的功能磁共振成像研究：Scoping综述[J]. 《中国康复理论与实践》, 2023, 29(2): 193-204.
[3]	祝莉洁,贠国俊,张伟云,刘青,曹建国. 超声成像技术在痉挛型脑性瘫痪患儿腓肠肌定量评定中的应用[J]. 《中国康复理论与实践》, 2022, 28(9): 1079-1083.
[4]	张晓钰,杨帆,温建忠,于卫永. 静息态脑功能磁共振成像在急性轻型脑外伤中的应用[J]. 《中国康复理论与实践》, 2022, 28(9): 1084-1088.
[5]	尹敏敏,凌星,杨亚茹,戴蘅钰,葛胜男,黄昭鸣. 基于WHO-FICs构建言语流畅性障碍的诊断、评估和整体康复方案[J]. 《中国康复理论与实践》, 2022, 28(6): 630-636.
[6]	葛胜男,王勇丽,尹敏敏,万勤,杨亚茹,黄昭鸣. 脑性瘫痪并发言语障碍的诊断、评估与康复：基于WHO-FICs研究[J]. 《中国康复理论与实践》, 2022, 28(6): 637-645.
[7]	蔡桂燕,陈瑞琳,徐姝蕊,陶静,刘娇. 膝骨关节炎和腰痛患者的脑低频振幅影像学特征比较[J]. 《中国康复理论与实践》, 2022, 28(5): 602-608.
[8]	史昊楠,谢瑛,桂沛君,张勃,陈宸. 经颅微电流刺激对老年轻度认知功能障碍的效果[J]. 《中国康复理论与实践》, 2022, 28(3): 346-349.
[9]	陈思齐,赵航,王洁,夏彬,刘巧云. 2~6岁儿童沟通功能量表的开发与标准化：基于ICF-CY[J]. 《中国康复理论与实践》, 2022, 28(12): 1444-1451.
[10]	蒋嘉蕊,牛振东. 深度学习在阿尔茨海默病诊断中应用近5年文献的可视化分析[J]. 《中国康复理论与实践》, 2022, 28(11): 1318-1324.
[11]	单洁玲,朱俞岚,阮婷婷,顾晟晨,黄凯文,李蕴,朱玉连. 剪切波弹性成像在辅助软组织松解术后跟腱功能评估中的应用[J]. 《中国康复理论与实践》, 2021, 27(9): 1098-1103.
[12]	何蕾,柴双双,陈亚平. 平衡评估训练系统对脑卒中后平衡功能的康复效果[J]. 《中国康复理论与实践》, 2021, 27(7): 760-764.
[13]	戴燕红, 黄嘉英, 罗海龙, 汪睿清, 黄颖安, 陈卓铭, 王红. 脑皮质梗死慢性期非流利性失语症灰质体积的改变[J]. 《中国康复理论与实践》, 2021, 27(7): 785-790.
[14]	陈明珍,姜凡,单永,洪永锋,刘学,肖洪波,陈瑞全. 多模态超声成像在脑卒中患者腓肠肌痉挛评估中的应用[J]. 《中国康复理论与实践》, 2021, 27(7): 791-796.
[15]	英小倩,高轶,廖利民. 健康女性强烈排尿感脑功能网络的小世界特征[J]. 《中国康复理论与实践》, 2021, 27(5): 510-515.