Wnt信号通路在脊髓损伤修复中作用的实验研究进展

doi:10.3969/j.issn.1006-9771.2017.06.005

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (6): 645-648.doi: 10.3969/j.issn.1006-9771.2017.06.005

Wnt信号通路在脊髓损伤修复中作用的实验研究进展

满夏楠, 陈健尔

浙江中医药大学第三临床医学院,浙江杭州市 310053。

收稿日期:2017-02-14 修回日期:2017-03-19 出版日期:2017-06-25 发布日期:2017-06-27
通讯作者: 陈健尔(1954-),男,浙江杭州市人,硕士,教授,硕士研究生导师,主要研究方向：神经康复。E-mail: cje28@foxmail.com。
作者简介:满夏楠(1989-)，女，汉族，山东滕州市人，硕士研究生，主要研究方向：神经脊髓损伤中西医结合康复治疗研究。
基金资助:
1.浙江省公益性技术应用研究计划项目(No.2012C33066); 2.浙江省中医药科技计划项目(No.2012ZA123)

Experimental Research Progress of Wnt Signaling Pathway in Spinal Cord Injury Repair (review)

MAN Xia-nan, CHEN Jian-er

Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

Received:2017-02-14 Revised:2017-03-19 Published:2017-06-25 Online:2017-06-27
Contact: Correspondence to CHEN Jian-er. E-mail: cje28@foxmail.com

摘要/Abstract

摘要： Wnt信号通路是参与调控神经系统发育和参与脊髓损伤修复的重要信号转导系统之一,在轴突再生、神经干细胞增殖并向神经元分化,而抑制向胶质细胞分化等方面起重要作用。脊髓损伤后,损伤部位周围多种Wnt蛋白表达。Wnt家族中的一些蛋白在脊髓损伤修复中发挥着重要作用,Wnt/β-catenin信号通路的激活更是脊髓损伤后脊髓再生的必要步骤。

关键词: Wnt信号通路, 脊髓损伤, 神经干细胞, Wnt/β-catenin通路, 综述

Abstract: Wnt signaling pathway is one of the important signal transduction systems that involved in regulating nervous system development, which plays an important role in axonal regeneration, neural stem cell proliferation and differentiation into neurons and inhibition of differentiation into glial cells. After spinal cord injury, multiple Wnt protein expresses around the injury site, and some proteins of the Wnt family play an important role in spinal cord injury repair, in which the activation of Wnt/β-catenin signaling pathway is necessary for spinal cord regeneration after spinal cord injury.

Key words: Wnt signaling pathway, spinal cord injury, neural stem cells, Wnt/β-catenin pathway, review

中图分类号:

R651.2

满夏楠, 陈健尔. Wnt信号通路在脊髓损伤修复中作用的实验研究进展[J]. 《中国康复理论与实践》, 2017, 23(6): 645-648.

MAN Xia-nan, CHEN Jian-er. Experimental Research Progress of Wnt Signaling Pathway in Spinal Cord Injury Repair (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(6): 645-648.

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Wnt信号通路在脊髓损伤修复中作用的实验研究进展

Experimental Research Progress of Wnt Signaling Pathway in Spinal Cord Injury Repair (review)

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