MicroRNA在脊髓损伤中的研究进展

doi:10.3969/j.issn.1006-9771.2017.06.006

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (6): 649-653.doi: 10.3969/j.issn.1006-9771.2017.06.006

MicroRNA在脊髓损伤中的研究进展

张文豪^1,2,3,4, 李建军^1,2,3,4, 杨德刚^1,2,3,4, 高品操⁵, 杨明亮^1,2,3,4, 杜良杰^1,2,3,4, 高峰^1,2,3,4, 唐芳⁵, 刘长彬^1,2,3,4, 李大鹏^1,2,3,4, 张鑫^1,2,3,4, 张洁^1,2,3,4

1.首都医科大学康复医学院,北京市 100068;
2.中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科,北京市 100068;
3.北京脑重大疾病研究院神经损伤与修复研究所,北京市 100068;
4.北京市神经损伤与康复重点实验室,北京市 100068;
5.湖南医药学院,湖南怀化市 418000。

收稿日期:2016-11-01 修回日期:2016-11-18 出版日期:2017-06-25 发布日期:2017-06-27
通讯作者: 李建军(1962-),男,汉族,教授,主任医师,博士、博士后导师,主要研究方向：骨科及脊柱脊髓损伤的康复与治疗。E-mail: crrc100@163.com。
作者简介:张文豪(1991-),男,汉族,河南柘城县人,硕士研究生,主要研究方向：脊柱脊髓损伤的康复与治疗。
基金资助:
1.国家自然科学基金面上项目(No.81272164); 2.中央级公益性科研院所基本科研业务费专项资金项目(No.2015CZ-6)

Research Progress of MicroRNA in Spinal Cord Injury (review)

ZHANG Wen-hao^1,2,3,4, LI Jian-jun^1,2,3,4, YANG De-gang^1,2,3,4, GAO Pin-cao⁵, YANG Ming-liang^1,2,3,4, DU Liang-jie^1,2,3,4, GAO Feng^1,2,3,4, TANG Fang⁵, LIU Chang-bin^1,2,3,4, LI Da-peng^1,2,3,4, ZHANG Xin^1,2,3,4, ZHANG Jie^1,2,3,4

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China;
2. Department of Spinal and Neural Function Reconstruction, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China;
3. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China;
4. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China;
5. Hunan Medical University, Huaihua, Hunan 418000, China

Received:2016-11-01 Revised:2016-11-18 Published:2017-06-25 Online:2017-06-27
Contact: Correspondence to LI Jian-jun. E-mail: crrc100@163.com

摘要/Abstract

摘要： microRNA是能够调控靶基因表达的小分子RNA,在脊髓发育和脊髓损伤等过程的基因表达中具有重要作用,可能是促进脊髓损伤后神经再生和修复的治疗性干预新靶点,是脊髓损伤潜在的生物学标志物。本文从microRNA在脊髓损伤中的机制及热点microRNA方面做一综述。

关键词: 脊髓损伤, microRNA, 基因表达, 转录调控, 生物学标记, 新靶点, 综述

Abstract: MicroRNAs are short non-coding RNAs that regulate and control the translation of target genes, and play an important role in gene expression involved in the development of spinal cord and spinal cord injury, which constitute novel targets for therapeutic intervention to promote repair and regeneration of the spinal cord, also they are the potential biomarkers of spinal cord injury. This article reviewed the mechanism of microRNAs and listed several microRNAs in spinal cord injury area.

Key words: spinal cord injury, microRNA, gene expression, transcriptional regulation, biological markers, novel targets, review

中图分类号:

R651.2

张文豪, 李建军, 杨德刚, 高品操, 杨明亮, 杜良杰, 高峰, 唐芳, 刘长彬, 李大鹏, 张鑫, 张洁. MicroRNA在脊髓损伤中的研究进展[J]. 《中国康复理论与实践》, 2017, 23(6): 649-653.

ZHANG Wen-hao, LI Jian-jun, YANG De-gang, GAO Pin-cao, YANG Ming-liang, DU Liang-jie, GAO Feng, TANG Fang, LIU Chang-bin, LI Da-peng, ZHANG Xin, ZHANG Jie. Research Progress of MicroRNA in Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(6): 649-653.

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MicroRNA在脊髓损伤中的研究进展

Research Progress of MicroRNA in Spinal Cord Injury (review)

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