脊髓栓系综合征动物模型制作方法的研究进展

doi:10.3969/j.issn.1006-9771.2017.06.012

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (6): 677-680.doi: 10.3969/j.issn.1006-9771.2017.06.012

脊髓栓系综合征动物模型制作方法的研究进展

李大鹏^1,3,4, 杨德刚^1,3,4, 张文豪^1,3,4, 刘长彬^1,3,4, 蔡畅^1,3,4, 张鑫^1,3,4, 郭韵^1,3,4, 张力伟⁵, 胡安明¹, 杜良杰^1,3,4, 杨明亮^1,3,4, 李建军^1,3,4

1.首都医科大学康复医学院,北京市 100068;
2.中国康复研究中心北京博爱医院,a.脊柱脊髓神经功能重建科;b.神经外科,北京市 100068;
3.北京脑重大疾病研究院神经损伤与修复研究所,北京市 100068;
4.北京市神经损伤与康复重点实验室,北京市 100068;
5.首都医科大学附属北京天坛医院神经外科,北京市 100050。

收稿日期:2016-12-09 修回日期:2017-01-12 出版日期:2017-06-25 发布日期:2017-06-27
通讯作者: 李建军,男,汉族,教授,主任医师,博士、博士后导师,主要研究方向：骨科及脊柱脊髓损伤的康复与治疗。E-mail: crrc100@163.com。
作者简介:李大鹏(1976-),男,汉族,江苏徐州市人,博士研究生,主治医师,主要研究方向：脊髓、脊柱。
基金资助:
1.国家自然科学基金项目(No.81271366; No.81272164); 2.中央级公益性科研院所基本科研业务费专项资金项目(No.2015CZ-6); 3.中国康复研究中心课题(No.2012-1; No.2013-7)

Research Progress of Model Establishment for Tethered Cord Syndrome (review)

LI Da-peng^1,3,4, YANG De-gang^1,3,4, ZHANG Wen-hao^1,3,4, LIU Chang-bin^1,3,4, CAI Chang^1,3,4, ZHANG Xin^1,3,4, GUO Yun^1,3,4, ZHANG Li-wei⁵, HU An-ming¹, DU Liang-jie^1,3,4, YANG Ming-liang^1,3,4, LI Jian-jun^1,3,4

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China;
2. a. Department of Spinal and Neural Function Reconstruction; b. Department of Neurosurgery, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China;
3. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100068, China;
4. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China;
5. Capital Medical University, Beijing Tiantan Hospital, Beijing 100050, China

Received:2016-12-09 Revised:2017-01-12 Published:2017-06-25 Online:2017-06-27
Contact: Correspondence to LI Jian-jun. E-mail: crrc100@163.com

摘要/Abstract

摘要： 脊髓栓系综合征(TCS)是一种渐进性进展的神经发育障碍性疾病。目前TCS动物模型的制作方法主要有物理因素制作、化学因素制作和手术制作。这些动物模型普遍存在的问题是未能真实反映人类TCS渐进性进展的病程。未来该领域的研究方向是选取一个病因,单因素地分析该疾病,并逐步叠加,直至对该疾病有一个较深的了解。

关键词: 脊髓栓系综合征, 动物模型, 制作方法, 综述

Abstract: Tethered cord syndrome (TCS) is a progressive neurodevelopmental disorder. The TCS model was established mainly using physical and chemical Methods and surgery, but remained problems in failing to fully reflect the progressive course of the human TCS. In the future, it may select a single etiological factor to analyze, and gradually add other factors until we have deeper understanding of this disease.

Key words: tethered cord syndrome, animal model, establishment methods, review

中图分类号:

R651.2

李大鹏, 杨德刚, 张文豪, 刘长彬, 蔡畅, 张鑫, 郭韵, 张力伟, 胡安明, 杜良杰, 杨明亮, 李建军. 脊髓栓系综合征动物模型制作方法的研究进展[J]. 《中国康复理论与实践》, 2017, 23(6): 677-680.

LI Da-peng, YANG De-gang, ZHANG Wen-hao, LIU Chang-bin, CAI Chang, ZHANG Xin, GUO Yun, ZHANG Li-wei, HU An-ming, DU Liang-jie, YANG Ming-liang, LI Jian-jun. Research Progress of Model Establishment for Tethered Cord Syndrome (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(6): 677-680.

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脊髓栓系综合征动物模型制作方法的研究进展

Research Progress of Model Establishment for Tethered Cord Syndrome (review)

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