不同提示策略下帕金森病言语运动调控的机制

doi:10.3969/j.issn.1006-9771.2018.00.004

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (7): 779-786.doi: 10.3969/j.issn.1006-9771.2018.00.004

不同提示策略下帕金森病言语运动调控的机制

李婧婷¹, 黄曦妍², 范豪³, 李咏雪¹, 刘鹏¹, 陈曦¹

1.中山大学附属第一医院康复医学科,广东广州市 510080;
2.南方医科大学珠江医院康复医学科,广东广州市 510280;
3.郑州大学第一附属医院康复医学科,河南郑州市 450052

收稿日期:2018-04-17 修回日期:2018-05-10 出版日期:2018-07-25 发布日期:2018-08-01
通讯作者: 陈曦。E-mail: chenxi73@163.com
作者简介:李婧婷(1993-),女,汉族,重庆市人,硕士研究生,主要研究方向：言语认知神经科学。通讯作者：陈曦,女,博士,主任医师。
基金资助:
1.国家自然科学基金项目(No. 81472154; No. 81772439); 2.广东省科技计划项目(No. 2017A050501014); 3.广州市科技计划项目(No. 201604020115)

Neural Mechanisms of Speech Motor Control in Parkinson's Disease under Different Cueing Strategies

LI Jing-ting¹, HUANG Xi-yan², FAN Hao³, LI Yong-xue¹, LIU Peng¹, CHEN Xi¹

1. Department of Rehabilitation Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
2. Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China;
3. Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Received:2018-04-17 Revised:2018-05-10 Published:2018-07-25 Online:2018-08-01
Contact: CHEN Xi. E-mail: chenxi73@163.com
Supported by:
Supported by National Natural Science Foundation of China (No. 81472154; No. 81772439), Guangdong Science and Technology Program (No. 2017A050501014) and Guangzhou Science and Technology Program (No. 01604020115)

摘要/Abstract

摘要： 目的研究帕金森病患者在不同运动执行控制模式下的言语运动调控神经机制。方法利用基于听觉反馈扰动的心理声学和事件相关电位技术,17例帕金森病患者和17例正常受试者在内部提示策略和外部提示策略下进行主动发声,在此过程中言语基频反馈会被随机降低,记录和分析产生的声学补偿响应和皮层诱发电位。结果帕金森病组产生的声学补偿响应幅度大于正常对照组(F=5.415, P=0.027),但两种发声任务之间主效应不显著(F=0.039, P=0.840)。在皮层水平上,在帕金森病组中外部提示任务产生的N1成分幅度明显小于内部提示任务(F=8.634, P=0.006),在正常对照组实验任务主效应不显著(F=1.550, P=0.231)。在内部提示发声任务中,帕金森病组产生的N1幅度大于正常对照组(F=5.476, P=0.026),但在外部提示任务中组间效应不显著(F=0.249, P=0.621)。结论帕金森病的言语运动调控与运动执行控制的提示策略有关,外部提示策略能够显著提高言语反馈信息的神经编码效率,改善听觉信息与发声运动的整合能力。

关键词: 帕金森病, 运动执行控制, 言语运动调控, 声学补偿响应, 事件相关电位

Abstract: Objective To investigate the neural mechanisms of speech motor control in individuals with Parkinson's disease (PD) under different strategies of motor execution control.MethodsThe techniques of the psychoacoustic and event-related potentials (ERPs) based on the altered auditory feedback paradigm were used in the present study. Two groups, including 17 PD patients and 17 healthy controls, were instructed to produce sustained vowels under the internal and external cueing tasks while hearing their voice randomly pitch-shifted downwards. The vocal responses and associated ERPs were recorded and compared across the groups and tasks.ResultsBehavioral results showed that the amplitude of acoustic compensation response was larger in PD patients than in the healthy controls (F=5.415, P=0.027), however, the main effect was not significant in the tasks (F=0.039, P=0.840). At the cortical level, PD patients produced significantly larger N1 responses to pitch perturbations in the internal cueing task related to the external cueing task (F=8.634, P=0.006), while such task effect was not observed in the healthy controls (F=1.550, P=0.231). Also, PD patients produced significantly larger N1 responses than the healthy controls in the internal cueing condition (F=5.476, P=0.026), but not in the external cueing condition (F=0.249, P=0.621). Conclusion Speech motor control in PD can be influenced by the strategies of motor execution control. Compared to the internal cueing task, the external cueing task can increase neural efficiency in the encoding of speech auditory feedback PD patients that improve auditory-motor integration for speech production.

Key words: Parkinson's disease, motor execution control, speech motor control, vocal compensation, event-related potentials

中图分类号:

R742.5

李婧婷, 黄曦妍, 范豪, 李咏雪, 刘鹏, 陈曦. 不同提示策略下帕金森病言语运动调控的机制[J]. 《中国康复理论与实践》, 2018, 24(7): 779-786.

LI Jing-ting, HUANG Xi-yan, FAN Hao, LI Yong-xue, LIU Peng, CHEN Xi. Neural Mechanisms of Speech Motor Control in Parkinson's Disease under Different Cueing Strategies[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(7): 779-786.

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不同提示策略下帕金森病言语运动调控的机制

Neural Mechanisms of Speech Motor Control in Parkinson's Disease under Different Cueing Strategies

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