帕金森病运动训练方法及其机制的研究进展

doi:10.3969/j.issn.1006-9771.2018.00.010

摘要/Abstract

摘要： 帕金森病是常见的中枢神经系统变性疾病。目前针对帕金森病的运动训练主要有太极拳、跑步机、舞蹈和平衡训练等。太极拳训练主要以改善平衡功能为主。跑步机训练以改善步态障碍为主。舞蹈训练不但可以改善平衡和步态,还对认知和情绪有一定的改善。运动训练可能的分子机制是改变黑质纹体内多巴胺能神经元含量、增加非多巴胺能递质的含量、增加脑源性神经营养因子、促进神经细胞的可塑性、降低氧化应激、增强线粒体活性和激活免疫系统等,以减缓多巴胺能神经元的变性,改善帕金森病的症状。

关键词: 帕金森病, 康复, 神经可塑性, 神经递质, 脑源性神经营养因子, 综述

Abstract: Parkinson's disease is a common degenerative disease of central nervous system. Exercise for Parkinson's disease includes Taiji Quan, treadmill, dance and balance training, etc. Taiji Quan exercise is mainly for balance function, and treadmill training for gait obstacles. Dance can improve not only balance and gait, but also cognition and emotion. The possible molecular mechanism may involve to adjust the content of dopaminergic neurons in the nigrostatin, increase the content of non-dopaminergic transmitters, increase brain-derived neurotrophic factors, promote the plasticity of nerve cells, reduce oxidative stress, enhance mitochondrial activity, and activate the immune system, etc., to slow the degeneration of dopaminergic neurons and improve the symptoms of Parkinson's disease.

Key words: Parkinson's disease, rehabilitation, neural plasticity, neurotransmitters, brain-derived neurotrophic factor, review

中图分类号:

R742.5

李亚慧, 李晓红. 帕金森病运动训练方法及其机制的研究进展[J]. 《中国康复理论与实践》, 2019, 25(1): 51-54.

LI Ya-hui, LI Xiao-hong. Advance in Exercise and Related Mechanisms for Parkinson's Disease (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(1): 51-54.

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