丰富环境促进缺氧缺血性脑损伤神经可塑性的研究进展

doi:10.3969/j.issn.1006-9771.2018.05.003

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (5): 509-512.doi: 10.3969/j.issn.1006-9771.2018.05.003

• 专题缺血性脑损伤的评定与康复 • 上一篇下一篇

丰富环境促进缺氧缺血性脑损伤神经可塑性的研究进展

吕富岩, 张雷红, 宫兆帅, 苑爱云

青岛市妇女儿童医院神经康复科,山东青岛市 266034

收稿日期:2017-12-07 修回日期:2018-01-30 出版日期:2018-05-25 发布日期:2018-05-24
通讯作者: 苑爱云。E-mail: yay79429@126.com
作者简介:吕富岩(1973-),女,汉族,山东龙口市人,主管护师,主要研究方向：儿童神经康复与医院管理。通讯作者：苑爱云(1979-),女,汉族,山东安丘市人,博士,主治医师,主要研究方向：儿童神经康复。
基金资助:
1.山东省医药卫生科技发展计划项目(No. 2015WS0352); 2.青岛市卫生科技计划项目(No. 2015-WJZD091); 3.青岛市医药科研指导计划项目(No. 2016-WJZD084); 4.青岛市医疗卫生优秀人才培养项目(No. 2017.1-2019.12)

Advance of Enriched Environment in Neural Plasticity post Hypoxic-ischemic Brain Damage (review)

LÜ Fu-yan, ZHANG Lei-hong, GONG Zhao-shuai, YUAN Ai-yun

Department of Neurology Rehabilitation, Qingdao Women and Children's Hospital, Qingdao, Shandong 266034, China

Received:2017-12-07 Revised:2018-01-30 Published:2018-05-25 Online:2018-05-24
Contact: YUAN Ai-yun. E-mail: yay79429@126.com
Supported by:
Supported by　Shandong Medical and Health Research Development Plan (No. 2015WS0352), Qingdao Health Research Plan (No. 2015-WJZD091), Qingdao Medical Research Plan (No. 2016-WJZD084) and Qingdao Medical and Health Professional Training (No. 2017.1-2019.12)

摘要/Abstract

摘要： 丰富环境是针对啮齿类动物习性制备的动物实验模型环境。缺氧缺血性脑损伤(HIBD)动物模型在丰富环境干预下,可增强突触可塑性,抑制神经元凋亡,调节细胞自噬,从而促进HIBD后神经功能修复。

关键词: 缺氧缺血性脑损伤, 丰富环境, 神经可塑性, 凋亡, 自噬, 综述

Abstract: The enriched environment is an artificial environment for animal models of rodentia. In the enriched environment, model animals may improve synaptic plasticity, inhibit apoptisis and regulate autophage after hypoxic-ischemic brain damage, that promote the recovery.

Key words: hypoxic-ischemic brain damage, enriched environment, neural plasticity, apoptisis, autophage, review

中图分类号:

R742.3

吕富岩, 张雷红, 宫兆帅, 苑爱云. 丰富环境促进缺氧缺血性脑损伤神经可塑性的研究进展[J]. 《中国康复理论与实践》, 2018, 24(5): 509-512.

LÜ Fu-yan, ZHANG Lei-hong, GONG Zhao-shuai, YUAN Ai-yun. Advance of Enriched Environment in Neural Plasticity post Hypoxic-ischemic Brain Damage (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(5): 509-512.

参考文献

[1] Hebb DO.The effects of early experience on problem solving at maturity[J]. Am Psychol, 1947, 2: 306-307.
[2] Will B, Galani R, Kelche C, et al.Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002)[J]. Prog Neurobiol, 2004, 72(3): 167-182.
[3] Birch AM, McGarry NB, Kelly AM. Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner[J]. Hippocampus, 2013, 23(6): 437-450.
[4] 陈光福,张蕴芳,龙琦,等. 丰富环境干预促进缺氧缺血性脑损伤新生大鼠神经元细胞增殖和功能修复[J]. 中国当代儿科杂志, 2012, 14(2): 139-143.
[5] Seo JH, Yu JH, Suh H, et al.Fibroblast growth factor-2 induced by enriched environment enhances angiogenesis and motor function in chronic hypoxic-ischemic brain injury[J]. PLoS One, 2013, 8(9): e74405.
[6] Rojas JJ, Deniz BF, Schuch CP, et al.Environmental stimulation improves performance in the ox-maze task and recovers Na+, K+-ATPase activity in the hippocampus of hypoxic-ischemic rats[J]. Neuroscience, 2015, 291: 118-127.
[7] Vivinetto AL, Suárez MM, Rivarola MA.Neurobiological effects ofneonatal maternal separation and post-weaning environmental enrichment[J]. Behav Brain Res, 2013, 240: 110-118.
[8] Marques MR, Stigger F, Segabinazi E, et al.Beneficial effects of early environmental enrichment on motor development and spinal cord plasticity in a rat model of cerebral palsy[J]. Behav Brain Res, 2014, 263: 149-157.
[9] Kolb B, Mychasiuk R, Williams P, et al.Brain plasticity and recovery from early cortical injury. Developmental medicine and child neurology[J]. Dev Med Child Neurol, 2011, 53(Suppl 4): 4-8.
[10] Leggio MG, Mandolesi L, Federico F, et al.Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat[J]. Behav Brain Res, 2005, 163(1): 78-90.
[11] Malik R, Chattarji S.Enhanced intrinsic excitability and EPSP-spike coupling accompany enriched environment-induced facilitation of LTP in hippocampal CA1 pyramidal neurons[J]. J Neurophysiol, 2012, 107(5): 1366-1378.
[12] Hosseiny S, Pietri M, Petit-Paitel A, et al.Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development[J]. Brain Struct Funct, 2015, 220(6): 3435-3448.
[13] Pereira LO, Nabinger PM, Strapasson AC, et al.Long-term effects of environmental stimulation following hypoxia-ischemia on the oxidative state and BDNF levels in rat hippocampus and frontal cortex[J]. Brain Res, 2009, 1247: 188-195.
[14] Mazarakis NK, Mo C, Renoir T, et al.'Super-Enrichment' reveals dose-dependent therapeutic effects of environmental stimulation in a transgenic mouse model of Huntington's disease[J]. J Huntingtons Dis, 2014, 3(3): 299-309.
[15] Sheikhzadeh F, Etemad A, Khoshghadam S, et al.Hippocampal BDNF content in response to short- and long-term exercise[J]. Neurol Sci, 2015, 36(7): 1163-1166.
[16] Woodbury ME, Ikezu T.Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration[J]. J Neuroimmune Pharmacol, 2014, 9(2): 92-101.
[17] Au AK, Chen Y, Du L, et al.Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro[J]. Biochim Biophys Acta, 2015, 1852(9): 1902-1911.
[18] Isgor C, Pare C, McDole B, et al. Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus[J]. Neuroscience, 2015, 288: 10-23.
[19] Venna VR, Xu Y, Doran SJ, et al.Social interaction plays a critical role in neurogenesis and recovery after stroke[J]. Transl Psychiatry, 2014, 4: e351.
[20] Bayod S, Mennella I, Sanchez-Roige S, et al.Wnt pathway regulation by long-term moderate exercise in rat hippocampus[J]. Brain Res, 2014, 1543: 38-48.
[21] Griñan-Ferré C, Pérez-Cáceres D, Gutiérrez-Zetina SM, et al.Environmental enrichment improves behavior, cognition, and brain functional markers in young senescence-accelerated prone mice (SAMP8)[J]. Mol Neurobiol, 2016, 53(4): 2435-2450.
[22] Takahashi T, Shimizu K, Shimazaki K, et al.Environmental enrichment enhances autophagy signaling in the rat hippocampus[J]. Brain Res, 2014, 1592: 113-123.
[23] Otabe H, Nibuya M, Shimazaki K, et al.Electroconvulsive seizures enhance autophagy signaling in rat hippocampus[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 50: 37-43.
[24] 宫阳阳,侯梅,苑爱云,等. 早期运动干预对脑缺血缺氧幼鼠海马区突触素蛋白表达的影响[J]. 中华物理医学与康复杂志, 2016, 38(5): 325-328.
[25] Navone F, Genevini P, Borgese N.Autophagy and neurodegeneration: insights from a cultured cell model of ALS[J]. Cells, 2015, 4(3): 354-386.
[26] López-Lluch G.Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity[J]. Mech Ageing Dev, 2017, 162: 108-121.
[27] Kwon I, Jang Y, Cho JY, et al.Long-term resistance exercise-induced muscular hypertrophy is associated with autophagy modulation in rats[J]. J Physiol Sci, 2018, 68(3): 269-280.
[28] Bockaert J, Marin P. mTOR in brain physiology and pathologies[J]. Physiol Rev, 2015, 95(4): 1157-1187.
[29] Shehata M, Inokuchi K.Does autophagy work in synaptic plasticity and memory?[J]. Rev Neurosci, 2014, 25(4): 543-557.
[30] Takahashi T, Shimizu K, Shimazaki K, et al.Environmental enrichment enhances autophagy signaling in the rat hippocampus[J]. Brain Res, 2014, 1592: 113-123.
[31] Otabe H, Nibuya M, Shimazaki K, et al.Electroconvulsive seizures enhance autophagy signaling in rat hippocampus[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 50: 37-43.
[32] Lu Q, Harris VA, Kumar S, et al.Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress[J]. Redox Biol, 2015, 6: 516-523.
[33] Xu LX, Tang XJ, Yang YY, et al.Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats[J]. Neural Regen Res, 2017, 12(3): 417-424.
[34] Papadakis M, Hadley G, Xilouri M, et al.Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy[J]. Nat Med, 2013, 19(3): 351-357.

丰富环境促进缺氧缺血性脑损伤神经可塑性的研究进展

Advance of Enriched Environment in Neural Plasticity post Hypoxic-ischemic Brain Damage (review)

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