经颅直流电刺激对卒中后抑郁的疗效

doi:10.3969/j.issn.1006-9771.2018.05.015

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (5): 565-570.doi: 10.3969/j.issn.1006-9771.2018.05.015

经颅直流电刺激对卒中后抑郁的疗效

李泓钰¹, 王强^1,2,3, 王静⁴, 宋鲁平^1,2,3

1.首都医科大学康复医学院,北京市 100068;
2.中国康复研究中心北京博爱医院,北京市 100068;
3.神经损伤与康复北京市重点实验室,北京市 100068;
4.首都医科大学基础医学院,北京市 100069

收稿日期:2018-02-25 修回日期:2018-04-09 出版日期:2018-05-25 发布日期:2018-05-24
通讯作者: 宋鲁平。E-mail: songluping882002@aliyun.com
作者简介:李泓钰(1993-),女,汉族,甘肃兰州市人,硕士研究生,主要研究方向：神经康复、认知神经科学。通讯作者：宋鲁平(1964-),女,汉族,主任医师、教授,博士研究生导师,主要研究方向：神经康复、认知神经科学。
基金资助:
1.中央级公益性科研院所基本科研业务费专项资金项目(No. 2016CZ-6); 2.国家重点研发计划重点专项(No. 2016YFF0201002); 3.中国康复研究中心项目(No. 2017ZX-12)

Effect of Transcranial Direct Current Stimulation on Post-stroke Depression

LI Hong-yu¹, WANG Qiang^1,2,3, WANG Jing⁴, SONG Lu-ping^1,2,3

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China;
2. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China;
3. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China;
4. Capital Medical University School of Basic Medical Sciences, Beijing 100069, China

Received:2018-02-25 Revised:2018-04-09 Published:2018-05-25 Online:2018-05-24
Contact: SONG Lu-ping. E-mail: songluping882002@aliyun.com
Supported by:
Supported by　Special Fund Project for Basic Scientific Research Business of Central Public Scientific Research Institute (No. 2016CZ-6), National Key Research and Development Program (No. 2016YFF0201002) and China Rehabilitation Research Center Project (No. 2017ZX-12)

摘要/Abstract

摘要： 目的观察经颅直流电刺激(tDCS)对卒中后抑郁(PSD)患者情绪及认知功能的影响。方法 2017年2月至8月,PSD患者26例随机分为对照组和实验组各13例。在舍曲林治疗基础上,实验组采用tDCS治疗,对照组采用假刺激治疗,共4周。治疗前后采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和简易精神状态检查(MMSE)进行评估。结果实验组12例、对照组10例完成研究。治疗后,两组HAMD、HAMA和MMSE评分均较治疗前改善(t>2.331, P<0.05),治疗前后差值两组间均无显著性差异(t<1.642, P>0.05)。治疗后,实验组HAMD焦虑/躯体化因子、认知障碍因子、迟缓因子与绝望感因子分降低(t>2.493, P<0.05),对照组绝望感因子分降低(t=2.862, P<0.05);各因子分差值组间比较,迟缓因子分有显著性差异(t=2.354, P<0.05)。结论 tDCS对PSD患者的抑郁情绪有一定效果。

关键词: 卒中后抑郁, 经颅直流电刺激, 抑郁, 焦虑, 认知功能

Abstract: Objective To observe the effects of transcranial direct current stimulation (tDCS) on depression, anxiety and cognitive function in patients with post-stroke depression (PSD). Methods From February to August, 2017, 26 patients with PSD were randomly divided into control group (n=13) and treatment group (n=13). All the patients accepted sertraline, while the treatment group accepted tDCS, and the control group accepted sham stimulation. They were evaluated with Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Mini-Mental State Examination (MMSE) before and after treatment. Results Twelve patients in the treatment group and ten patients in the control group completed the trial. The scores of HAMD, HAMA and MMSE improved in both groups (t>2.331, P<0.05), and there was no significant difference between two groups (t<1.642, P>0.05). The scores of anxiety/somatization factor, cognitive impairment factor, retardation factor and despair factor of HAMD improved in the treatment group after treatment (t>2.493, P<0.05), while only despair factor improved in the control group (t=2.862, P<0.05). The score of retardation factor was significantly different between two groups (t=2.354, P<0.05).Conclusion tDCS may work for the depression in PSD patients.

Key words: post-stroke depression, transcranial direct current stimulation, depression, anxiety, cognitive function

中图分类号:

R743.3

李泓钰, 王强, 王静, 宋鲁平. 经颅直流电刺激对卒中后抑郁的疗效[J]. 《中国康复理论与实践》, 2018, 24(5): 565-570.

LI Hong-yu, WANG Qiang, WANG Jing, SONG Lu-ping. Effect of Transcranial Direct Current Stimulation on Post-stroke Depression[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(5): 565-570.

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经颅直流电刺激对卒中后抑郁的疗效

Effect of Transcranial Direct Current Stimulation on Post-stroke Depression

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