KCNQ1基因7个位点单核苷酸多态性与糖尿病前期人群运动干预敏感性的关联

doi:10.3969/j.issn.1006-9771.2018.05.017

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (5): 575-580.doi: 10.3969/j.issn.1006-9771.2018.05.017

KCNQ1基因7个位点单核苷酸多态性与糖尿病前期人群运动干预敏感性的关联

1.兰州城市学院体育学院，甘肃兰州市 730070;
2.井冈山大学体育学院，江西吉安市 343009;
3.国营长风机器厂职工医院，甘肃兰州市 730070

收稿日期:2018-01-03 修回日期:2018-03-01 出版日期:2018-05-25 发布日期:2018-05-24
通讯作者: 王卉。E-mail: jgswh@163.com
作者简介:夏小慧(1973-),女,汉族,甘肃临洮市人,博士,教授,主要研究方向：运动人体科学。通讯作者：王卉,女,内蒙古乌海市人,博士,主要研究方向：运动人体科学。
基金资助:
1.国家体育总局重点领域类项目(No. 2014B025); 2.甘肃省哲学社会科学规划项目(No. YB116); 3. 甘肃省教育科学规划项目(No. GS[2017]GHBZ031)

Relationship between Single Nucleotide Polymorphisms in Seven Sites of KCNQ1 and Susceptibilities to Exercise in Prediabetes

XIA Xiao-hui¹, WANG Hui², ZHANG She-ping¹, XIA Hui-yun³

1. College of Physical Education, Lanzhou City University, Lanzhou, Gansu 730070, China;
2. College of Physical Education, Jinggangshan University, Ji'an, Jiangxi 343009, China;
3. Hospital of Changfeng Machine Factory, Lanzhou, Gansu 730070, China

Received:2018-01-03 Revised:2018-03-01 Published:2018-05-25 Online:2018-05-24
Contact: WANG Hui. E-mail: jgswh@163.com
Supported by:
Supported by　General Administration of Sport of China Research Project (Key) (No. 2014B025), Gansu Province Philosophy and Social Sciences Program (No. YB116) and Gansu Province Educational Science Program (No. GS[2017]GHBZ031)

摘要/Abstract

摘要： 目的探讨钾离子通道蛋白KCNQ1基因7个标签位点单核苷酸多态性与糖尿病前期人群运动干预效果的关系。方法 2015年1月,对70例糖代谢异常者进行有氧耐力训练12周,测定干预前后糖脂代谢相关生化指标,采用基质辅助激光解吸电离飞行时间质谱法解析受试者基因组基因型。结果最终66例完成检测。与rs2299620位点其他基因型相比,TT基因型餐后2 h血糖最低(F=5.460, P<0.05);与其他单体型相比,rs2237897-rs2299620位点C-T单体型、rs2299620-rs151290位点T-C单体型、rs2299620-rs2237892位点T-T单体型餐后2 h血糖下降更多(χ²>7.950, P<0.05),rs2237897-rs2299620位点T-C单体型空腹胰岛素下降更多(χ²=9.000, P<0.05),rs2283228-rs2237892位点A-C单体型低密度脂蛋白下降更多(χ²=15.820, P<0.001)。结论 KCNQ1基因rs2299620位点的TT基因型以及多个单体型人群,糖脂代谢对运动相对敏感。

关键词: KCNQ1基因, 单核苷酸多态性, 糖尿病前期, 运动, 敏感性

Abstract: Objective To observe the relationship between 7 single nucleotide polymorphisms (SNPs) in KCNQ1 gene region and the effects of exercise intervention on prediatbets. Methods From January, 2015, 70 prediabetes accepted aerobic endurance exercise for twelve weeks. The indexes related to glucose and lipid metabolism were measured before and after intervention. Their genotypes of SNPs were detected with matrix-assisted laser desorption/ionization time of flight mass spectrometry. Results A total of 66 cases finished the tests. Compared with other genotypes of rs2299620, two hours postprandial blood glucose (P2hBG) decreased the most in those with TT genotype (F=5.460, P<0.05). Compared with other haplotypes, P2hBG decreased more in those with C-T haplotype of rs2237897-rs2299620, T-C haplotype of rs2299620-rs151290 and T-T haplotype of rs2299620-rs2237892 (χ²>7.950, P<0.05), fasting insulin decreased more in those with T-C haplotype of rs2237897-rs2299620 (χ²=9.000, P<0.05), and low density lipoprotein decreased more in those with A-C haplotype of rs2283228-rs2237892 (χ²=15.820, P<0.001).Conclusion The prediatbets with TT genotype of rs2299620 and some haplotypes of KCNQ1 are susceptible to exercise intervention in glucose and lipid metabolism.

Key words: KCNQ1 gene, single nucleotide polymorphism, prediabetes, exercise, susceptibility

中图分类号:

R587.1

夏小慧, 王卉, 张社平, 夏惠芸. KCNQ1基因7个位点单核苷酸多态性与糖尿病前期人群运动干预敏感性的关联[J]. 《中国康复理论与实践》, 2018, 24(5): 575-580.

XIA Xiao-hui, WANG Hui, ZHANG She-ping, XIA Hui-yun. Relationship between Single Nucleotide Polymorphisms in Seven Sites of KCNQ1 and Susceptibilities to Exercise in Prediabetes[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(5): 575-580.

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KCNQ1基因7个位点单核苷酸多态性与糖尿病前期人群运动干预敏感性的关联

Relationship between Single Nucleotide Polymorphisms in Seven Sites of KCNQ1 and Susceptibilities to Exercise in Prediabetes

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