利鲁唑治疗脊髓损伤的研究进展

doi:10.3969/j.issn.1006-9771.2018.06.006

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (6): 650-653.doi: 10.3969/j.issn.1006-9771.2018.06.006

• 专题脊髓损伤的机制及干预 • 上一篇下一篇

利鲁唑治疗脊髓损伤的研究进展

吴启超^1a,张妍^1b,张雯秀^1b,张衍军^1a,刘亚东^1a,赵英伦^1a,刘宗建^1b,陈学明^1a,b

1.首都医科大学附属北京潞河医院,a.脊柱外科; b.中心实验室,北京市101149

收稿日期:2018-02-27 修回日期:2018-05-13 出版日期:2018-06-25 发布日期:2018-06-28
通讯作者: 陈学明。E-mail: xuemingchen@sina.com
作者简介:吴启超(1992-),男,汉族,黑龙江佳木斯市人,硕士研究生,主要研究方向：药物治疗大鼠脊髓损伤的研究。通讯作者：陈学明,男,博士,副教授,主要研究方向：脊髓损伤与神经再生。
基金资助:
1. 首都市民健康培育项目(No. Z161100000116064); 2. 北京市教委课题(No. KM201710025028)

Advance in Riluzole for Spinal Cord Injury (review)

WU Qi-chao^1a, ZHANG Yan^1b, ZHANG Wen-xiu^1b, ZHANG Yan-jun^1a, LIU Ya-dong^1a, ZHAO Ying-lun^1a, LIU Zong-jian^1b, CHEN Xue-ming^{1a, b}

1. a. Spine Surgery, b. Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

Received:2018-02-27 Revised:2018-05-13 Published:2018-06-25 Online:2018-06-28
Contact: CHEN Xue-ming. E-mail: xuemingchen@sina.com

摘要/Abstract

摘要： 脊髓损伤患者的治疗及护理给社会带来重大的经济负担。本文介绍利鲁唑治疗脊髓损伤的作用机制,包括阻滞Na⁺通道,降低谷氨酸介导的兴奋性毒性,促进神经营养因子的表达,减轻细胞氧化应激损伤和细胞凋亡等,以及利鲁唑相关临床试验的研究进展。

关键词: 脊髓损伤, 利鲁唑, 神经保护, 肌肉萎缩性侧索硬化症, 综述

Abstract: Spinal cord injury (SCI) is a disabling disease usually caused by trauma. The treatment and nursing of SCI patients has brought great economic burden to the society. This article introduced the mechanism of riluzole in treating spinal cord injury, including blocking Na⁺ channels, reducing glutamate-mediated excitotoxicity, promoting the expression of neurotrophic factors, and alleviating cellular oxidative stress damage and apoptosis, and the research progress on clinical trials of riluzole.

Key words: spinal cord injury, riluzole, neuroprotection, amyotrophic lateral sclerosis, review

中图分类号:

R651.2

吴启超,张妍,张雯秀,张衍军,刘亚东,赵英伦,刘宗建,陈学明. 利鲁唑治疗脊髓损伤的研究进展[J]. 《中国康复理论与实践》, 2018, 24(6): 650-653.

WU Qi-chao, ZHANG Yan, ZHANG Wen-xiu, ZHANG Yan-jun, LIU Ya-dong, ZHAO Ying-lun, LIU Zong-jian, CHEN Xue-ming. Advance in Riluzole for Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(6): 650-653.

参考文献

[1] Kumar R, Lim J, Mekary RA, et al.Traumatic spinal injury: global epidemiology and worldwide volume[J]. World Neurosurg, 2018, 113: e345-e363.
[2] Passuni D, Dalzotto E, F Gath C, et al. Reliability of the Spanish version of the Wheelchair Skills Test 4.2 for manual wheelchair users with spinal cord injury [J]. Disabil Rehabil Assist Technol, 2018-05-03: 1-4. doi: 10.1080/17483107.2018.1463404.[Epub ahead of print]
[3] Doble A.The pharmacology and mechanism of action of riluzole[J]. Neurology, 1996, 47(6 Suppl 4): S233-S241.
[4] Favero FM, Voos MC, Castro I, et al.Epidemiological and clinical factors impact on the benefit of riluzole in the survival rates of patients with ALS[J]. Arq Neuropsiquiatr, 2017, 75(8): 515-522.
[5] Tator CH, Hashimoto R, Raich A, et al.Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury[J]. J Neurosurg Spine, 2012, 17(1 Suppl): 157-229.
[6] Martins BC, Torres B, de Oliveira KM, et al. Association of riluzole and dantrolene improves significant recovery after acute spinal cord injury in rats[J]. Spine J, 2018, 18(3): 532-539.
[7] Lamanauskas N, Nistri A.Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro[J]. Eur J Neurosci, 2008, 27(10): 2501-2514.
[8] Caglar YS, Demirel A, Dogan I, et al. Effect of riluzole on spinal cord regeneration with hemisection method before injury [J]. World Neurosurg, 2018-05-10. pii: S1878-8750(18)30444-3. doi: 10.1016/j.wneu.2018.02.171.[Epub ahead of print].
[9] Schwartz G, Fehlings MG.Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole[J]. Prog Brain Res, 2002, 137: 177-190.
[10] Ulndreaj A, Badner A, Fehlings MG.Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury[J]. F1000Res, 2017, 6: 1907.
[11] Fehlings MG, Nakashima H, Nagoshi N, et al.Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial[J]. Spinal Cord, 2016, 54(1): 8-15.
[12] Xie RG, Zheng DW, Xing JL, et al.Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons[J]. PLoS One, 2011, 6(4): e18681.
[13] Wu Y, Satkunendrarajah K, Fehlings MG.Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia[J]. Neuroscience, 2014, 265: 302-312.
[14] Heurteaux C, Laigle C, Blondeau N, et al.Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia[J]. Neuroscience, 2006, 137(1): 241-251.
[15] Brennan BP, Hudson JI, Jensen JE, et al.Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole[J]. Neuropsychopharmacology, 2010, 35(3): 834-846.
[16] Chen C, Chen H, Xu C, et al.Role of interleukin-1beta in hypoxia-induced depression of glutamate uptake in retinal Muller cells[J]. Graefes Arch Clin Exp Ophthalmol, 2014, 252(1): 51-58.
[17] Diao L, Hellier JL, Uskert-Newsom J, et al.Diphenytoin, riluzole and lidocaine: three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity[J]. Neuropharmacology, 2013, 73: 48-55.
[18] Abdallah CG, Coplan JD, Jackowski A, et al.A pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD[J]. Eur Neuropsychopharmacol, 2013, 23(4): 276-284.
[19] Tator CH.Update on the pathophysiology and pathology of acute spinal cord injury[J]. Brain Pathol, 1995, 5(4): 407-413.
[20] Sadowsky C, Volshteyn O, Schultz L, et al.Spinal cord injury[J]. Disabil Rehabil, 2002, 24(13): 680-687.
[21] Tashiro S, Nakamura M, Okano H.The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models[J]. Neural Regen Res, 2017, 12(1): 43-46.
[22] Norenberg MD, Smith J, Marcillo A.The pathology of human spinal cord injury: defining the problems[J]. J Neurotrauma, 2004, 21(4): 429-440.
[23] Siddiqui AM, Khazaei M, Fehlings MG.Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury[J]. Prog Brain Res, 2015, 218: 15-54.
[24] Wagner FJ, Stewart WB.Effect of trauma dose on spinal cord edema[J]. J Neurosurg, 1981, 54(6): 802-806.
[25] Dasari VR, Veeravalli KK, Dinh DH.Mesenchymal stem cells in the treatment of spinal cord injuries: A review[J]. World J Stem Cells, 2014, 6(2): 120-133.
[26] Agrawal SK, Fehlings MG.Mechanisms of secondary injury to spinal cord axons in vitro: role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger[J]. J Neurosci, 1996, 16(2): 545-552.
[27] Stys PK, Sontheimer H, Ransom BR, et al.Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons[J]. Proc Natl Acad Sci U S A, 1993, 90(15): 6976-6980.
[28] Stys PK.General mechanisms of axonal damage and its prevention[J]. J Neurol Sci, 2005, 233(1-2): 3-13.
[29] Kwon BK, Stammers AM, Belanger LM, et al.Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury[J]. J Neurotrauma, 2010, 27(4): 669-682.
[30] Coderre TJ, Kumar N, Lefebvre CD, et al.A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain[J]. J Neurochem, 2007, 100(5): 1289-1299.
[31] Carbone M, Duty S, Rattray M.Riluzole elevates GLT-1 activity and levels in striatal astrocytes[J]. Neurochem Int, 2012, 60(1): 31-38.
[32] Mizuta I, Ohta M, Ohta K, et al.Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes[J]. Neurosci Lett, 2001, 310(2-3): 117-120.
[33] Caumont AS, Octave JN, Hermans E.Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells[J]. J Neurochem, 2006, 97(1): 128-139.
[34] Karadimas SK, Laliberte AM, Tetreault L, et al.Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy[J]. Sci Transl Med, 2015, 7(316): 194r-316r.
[35] Wu Y, Satkunendrarajah K, Teng Y, et al.Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury[J]. J Neurotrauma, 2013, 30(6): 441-452.
[36] Satkunendrarajah K, Nassiri F, Karadimas SK, et al.Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection[J]. Experimental Neurology, 2016, 276: 59-71.
[37] Fehlings MG, Wilson JR, Frankowski RF, et al.Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial[J]. J Neurosurg Spine, 2012, 17(1 Suppl): 151-156.

利鲁唑治疗脊髓损伤的研究进展

Advance in Riluzole for Spinal Cord Injury (review)

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	邵伟婷, 雷江华. 反应中断再定向干预孤独症谱系障碍儿童刻板语言的效果：Scoping综述[J]. 《中国康复理论与实践》, 2024, 30(1): 10-20.
[2]	王航宇, 葛可可, 范永红, 都丽露, 邹敏, 封磊. 基于ICD-11和ICF主动式音乐疗法改善认知障碍老年人认知功能的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 36-43.
[3]	闻嘉宁, 金秋艳, 张琦, 李杰, 司琦. 认知参与型身体活动对发展儿童青少年执行功能的效果：基于ICF的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 44-53.
[4]	葛可可, 范永红, 王航宇, 都丽露, 李长江, 邹敏. 失眠老年人正念干预健康效益的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 54-60.
[5]	刘冬, 徐子涵, 李江, 鞠萍. M1区联合背外侧前额叶高频重复经颅磁刺激对脊髓损伤后神经病理性疼痛患者脑电图θ振幅的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 87-94.
[6]	张婧雅, 邹敏, 孙宏伟, 孙昌隆, 朱峻同. 听障儿童青少年焦虑或抑郁情绪心理干预效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1004-1011.
[7]	王俊宇, 杨永, 袁逊, 谢婷, 庄洁. 高强度间歇训练对健康儿童青少年执行功能效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1012-1020.
[8]	魏晓微, 杨剑, 魏春艳. 特殊教育学校孤独症谱系障碍儿童参与适应性瑜伽活动的心理与行为效益的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1021-1028.
[9]	杨亚茹, 杨剑. 基于WHO-HPS架构学校身体活动相关健康服务及其健康效益：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1040-1047.
[10]	史佳伟, 李凌宇, 杨浩杰, 王琴潞, 邹海欧. 预康复对全膝关节置换术后患者的有效性：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1057-1064.
[11]	蒋长好, 黄辰, 高晓妍, 戴元富, 赵国明. 神经反馈训练对老年人认知功能效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(8): 903-909.
[12]	魏晓微, 杨剑, 魏春艳, 贺启令. 学校环境下适应性体育课程促进智力与发展性残疾儿童心理运动发展的系统综述[J]. 《中国康复理论与实践》, 2023, 29(8): 910-918.
[13]	李芳, 霍速, 杜巨豹, 刘秀贞, 李小爽, 宋为群. 经颅直流电刺激联合任务导向性康复训练对脊髓损伤大鼠前肢运动障碍的效果[J]. 《中国康复理论与实践》, 2023, 29(7): 777-781.
[14]	张园, 杨剑. 基于世界卫生组织健康促进学校架构的学校健康服务及效果：Scoping综述[J]. 《中国康复理论与实践》, 2023, 29(7): 791-799.
[15]	王少璞, 陈钢. 基于世界卫生组织健康促进学校架构的心理行为健康服务及其健康效益：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(7): 800-807.