Rab27a基因与外泌体的研究进展

doi:10.3969/j.issn.1006-9771.2018.10.008

摘要/Abstract

摘要： Rab27a基因可通过其编码的蛋白参与T淋巴细胞、肥大细胞、嗜中性粒细胞、胰腺β细胞及造血细胞等的颗粒分泌、运输及胞吐作用,参与白化病、癌症、糖尿病、炎症、血栓形成等疾病的发生发展。另外,Rab27a对外泌体的分泌调控作用也备受关注。本文就Rab27a基因调节外泌体的分泌及其基因修饰的外泌体在治疗炎症损伤、血栓形成及肿瘤等疾病方面的研究现状进行综述。

关键词: Rab27a基因, 外泌体, 炎症, 肿瘤, 综述

Abstract: Rab27a gene can participate in the secretion, transportation and exocytosis of T lymphocytes, mast cells, neutrophils, pancreatic β cells and hematopoietic cells through its encoded proteins, and participate in the development of diseases such as albinism, cancer, diabetes, inflammation and thrombosis. In addition, the secretion regulation of Rab27a to exosomes has also received much attention. The current research status of the secretion of exosome and the genetically modified exosomes of Rab27a gene in the treatment of diseases such as inflammatory injury, thrombosis and tumor were reviewed.

Key words: Rab27a gene, exosomes, inflammation, tumor, review

中图分类号:

R363

王小霞, 陈煜森, 马晓瑭, 潘群文, 黄子慧. Rab27a基因与外泌体的研究进展[J]. 《中国康复理论与实践》, 2018, 24(10): 1159-1164.

WANG Xiao-xia, CHEN Yu-sen, MA Xiao-tang, PAN Qun-wen, HUANG Zi-hui. Advance of Rab27a Gene and Exosomes (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(10): 1159-1164.

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