基于弥散张量纤维束成像探讨皮质脊髓束损伤对脑卒中运动功能障碍的评估价值

doi:10.3969/j.issn.1006-9771.2018.12.015

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (12): 1432-1437.doi: 10.3969/j.issn.1006-9771.2018.12.015

基于弥散张量纤维束成像探讨皮质脊髓束损伤对脑卒中运动功能障碍的评估价值

高鑫洁¹, 唐朝正^2,3, 徐国军¹, 余秋蓉¹, 杨浩¹, 贾杰², 孙莉敏², 尹大志⁴, 范明霞¹

1.华东师范大学上海市磁共振重点实验室,上海市 200062;
2.复旦大学附属华山医院康复医学科,上海市 200040;
3.北京师范大学认知神经科学与学习国家重点实验室,北京市 100875;
4.中国科学院上海生命科学研究院灵长类神经生物学重点实验室,上海市 200031

收稿日期:2018-03-07 修回日期:2018-04-22 出版日期:2018-12-25 发布日期:2019-01-04
通讯作者: 范明霞,女,博士,副教授,主要研究方向：磁共振成像在医学中的应用。范明霞。E-mail: mxfan@phy.ecnu.eu.cn
作者简介:高鑫洁(1993-),女,汉族,山西霍州市人,硕士研究生,主要研究方向：磁共振成像在医学中的应用。
基金资助:
1.国家自然科学基金面上项目(No. 81471651); 2.国家自然科学基金青年项目(No. 81401859); 3.科技部“十二五”支撑计划项目(No. 2013BAI10B03); 4.上海市卫生和计划生育委员会项目(No. 201440634); 5.上海市闸北区卫生局项目(No. 2014MS06)

Assessment Value of Disrupted Corticospinal Tract Secondary to Stroke Lesion for Motor Impairment: A Diffusion Tensor Tracking Study

GAO Xin-jie¹, TANG Chao-zheng^{2, 3}, XU Guo-jun¹, YU Qiu-rong¹, YANG Hao¹, JIA Jie², SUN Li-min², YIN Da-zhi⁴, FAN Ming-xia¹

1. Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China;
2. Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;
3. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China;
4. Laboratory of Primate Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received:2018-03-07 Revised:2018-04-22 Published:2018-12-25 Online:2019-01-04
Contact: FAN Ming-xia. E-mail: mxfan@phy.ecnu.eu.cn
Supported by:
National Natural Science Foundation of China (General) (No. 81471651), National Natural Science Foundation of China (Youth) (No. 81401859), National Science and Technology Support Program during the Twelfth Five-year Plan Period (No. 2013BAI10B03), Shanhai Municipal Commission of Health and Family Planning Program (No. 201440634) and Shanghai Zhabei District Health Bureau Program (No. 2014MS06)

摘要/Abstract

摘要： 目的采用弥散张量纤维束成像技术(DTT)研究脑卒中皮质脊髓束(CST)损伤程度与运动功能障碍的关系。方法 2012年3月至2013年6月,采集15例慢性期左侧皮质下脑卒中患者(脑卒中组)和15例年龄、性别匹配的健康志愿者(健康对照组)的弥散张量成像(DTI)数据,运用DTT技术追踪CST,以健康对照组CST模板定量评估脑卒中病灶引起的CST损伤程度,并进一步与Fugl-Meyer评定量表(FMA)作相关性分析。结果脑卒中组的CST损伤值范围为0.00%~29.6%。脑卒中组CST损伤值与腕(r = -0.660, P = 0.007)、手(r = -0.813, P < 0.001)和腕+手(r = -0.795, P < 0.001) FMA评分呈强负相关;与上肢(r = -0.614, P = 0.015)和上肢+下肢(r = -0.563, P = 0.029) FMA评分呈较强负相关;与下肢FMA评分无显著相关性(r = -0.270, P = 0.331)。脑卒中病灶体积大小与各运动功能评分均无明显相关性(P > 0.05)。结论病灶对CST的直接累及程度与脑卒中运动功能损害程度密切相关。DTT定量计算CST损伤值可作为评估脑卒中患者上肢,尤其是手腕部运动功能障碍的一个潜在重要参考指标。

关键词: 脑卒中, 弥散张量成像, 皮质脊髓束, 手, 上肢, 功能障碍

Abstract: Objective To investigate the relationship between disrupted corticospinal tract (CST) and motor recovery after stroke by using diffusion tensor tracking (DTT). Methods From March, 2012 to June, 2013, 15 chronic stroke patients with left subcortical lesions and 15 age- and sex- matched healthy subjects were performed diffusion tensor imaging (DTI) examination. The CST was tracked by DTT technique, and the damaged values of the CST caused by the stroke lesions were quantified using a CST template generated from healthy controls. Furthermore, the correlations of the damaged values of the CST with Fugl-Meyer Assessment (FMA) were performed. Results The range of the damaged values of CST in stroke patients was 0.00% to 29.6%. There were very strong negative correlation between the damaged values of the CST and FMA scores (the wrist, r = -0.660; hand, r = -0.813; wrist plus hand, r = -0.795, respectively, P < 0.01). It also showed strong negative correlation between the damaged values of the CST and FMA scores (upper limb, r = -0.614; upper limb plus lower limb, r = -0.563, respectively, P < 0.05). Whereas, there was no correlation between the damaged values of the CST and FMA scores of lower limb (r = -0.270, P = 0.331). In addition, the lesion volumes of stroke and FMA scores were not significantly correlated (P > 0.05). Conclusion The severity of motor deficit after stroke was closely related to the overlap of lesions with CST. The damaged values of the CST based on DTT may be used as a potential biomarker to assess motor impairments of upper limbs, especially hand and wrist in stroke patients.

Key words: stroke, diffusion tensor imaging, corticospinal tract, hand, upper extremity, dysfunction

中图分类号:

R743.3

高鑫洁, 唐朝正, 徐国军, 余秋蓉, 杨浩, 贾杰, 孙莉敏, 尹大志, 范明霞. 基于弥散张量纤维束成像探讨皮质脊髓束损伤对脑卒中运动功能障碍的评估价值[J]. 《中国康复理论与实践》, 2018, 24(12): 1432-1437.

GAO Xin-jie, TANG Chao-zheng, XU Guo-jun, YU Qiu-rong, YANG Hao, JIA Jie, SUN Li-min, YIN Da-zhi, FAN Ming-xia. Assessment Value of Disrupted Corticospinal Tract Secondary to Stroke Lesion for Motor Impairment: A Diffusion Tensor Tracking Study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(12): 1432-1437.

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基于弥散张量纤维束成像探讨皮质脊髓束损伤对脑卒中运动功能障碍的评估价值

Assessment Value of Disrupted Corticospinal Tract Secondary to Stroke Lesion for Motor Impairment: A Diffusion Tensor Tracking Study

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