磁共振Mapping技术诊断兔进展期椎间盘退变

doi:10.3969/j.issn.1006-9771.2019.02.008

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (2): 172-177.doi: 10.3969/j.issn.1006-9771.2019.02.008

磁共振Mapping技术诊断兔进展期椎间盘退变

胡莹莹¹, 应金威², 赵琪雯³, 王庆军¹

1. 海军总医院，a. 放射科；b. 骨科；c. 病理科，北京市100048

收稿日期:2018-09-19 修回日期:2018-10-10 出版日期:2019-02-25 发布日期:2019-04-01
通讯作者: 王庆军。E-mail： wangqingjun77@163.com
作者简介:胡莹莹(1988-)，女，汉族，吉林长春市人，医师，主要研究方向：磁共振成像研究。

Application of Magnetic Resonance Mapping in Progressive Intervertebral Disc Degeneration in Rabbits

HU Ying-ying¹, YING Jin-wei², ZHAO Qi-wen³, WANG Qing-jun¹

1.Department of Radiology，Navy General Hospital, Beijing 100048, China
2. Department of Orthopedics，Navy General Hospital, Beijing 100048, China
3. Department of Pathology, Navy General Hospital, Beijing 100048, China

Received:2018-09-19 Revised:2018-10-10 Published:2019-02-25 Online:2019-04-01
Contact: WANG Qing-jun. E-mail： wangqingjun77@163.com

摘要/Abstract

摘要： 目的探索磁共振T2 mapping和T1 mapping成像诊断兔进展期腰椎间盘退变的应用价值。方法 7只新西兰兔行椎间盘退变造模。造模前以及造模后1个月、3个月，行矢状位T1WI、T2WI、T2 mapping和T1 mapping扫描，基于T2WI，对L1~S1的6个椎间盘行Pfirrmann分级，基于T2 mapping和T1 mapping测量椎间盘T2值和T1值。观察相应椎间盘病理改变，以病理结果非进展期和进展期退变为标准，使用接受者操作特征(ROC)曲线判断各成像指标的诊断效能。结果造模前、造模后1个月和造模后3个月，椎间盘T2值显著降低(F = 24.224, P < 0.001)，椎间盘T1值无显著性差异(F = 2.191, P = 0.116)。诊断进展期椎间盘退变的效能从高到低依次为：T2 mapping+T1 mapping = T2 mapping > T1 mapping > Pfirrmann评分。结论 T2 mapping可以较准确地区分非进展期和进展期椎间盘退变。

关键词: 椎间盘退变, 磁共振成像, mapping, 兔

Abstract: Objective To apply magnetic resonance T2 mapping and T1 mapping in diagnosing progressive intervertebral disc degeneration. Methods Seven New Zealand rabbits modeled with intervertebral disc degeneration underwent sagittal T1WI, T2WI, T2 mapping and T1 mapping before, and one and three months after modeling. Pfirrmann grade of six intervertebral discs (L1-S1) in each rabbit was obtained based on T2WI and values of T2 and T1 based on T2 mapping and T1 mapping. They were observed pathologically as progressive or non-progressive intervertebral disc degeneration. The diagnostic efficacy of these imaging markers was compared with receiver operating characteristic (ROC) curve according to pathological results. Results T2 values of intervertebral discs decreased after degeneration (F = 24.224, P < 0.001), while T1 values varied little (F = 2.191, P = 0.116). The diagnostic efficacy from more to less ranked as T2 mapping+T1 mapping = T2 mapping > T1 mapping > Pfirrmann grade. Conclusion T2 mapping may differentiate progressive intervertebral disc degeneration from non-progressive for clinic.

Key words: intervertebral disc degeneration, magnetic resonance imaging, mapping, rabbits

中图分类号:

R681.5

胡莹莹, 应金威, 赵琪雯, 王庆军. 磁共振Mapping技术诊断兔进展期椎间盘退变[J]. 《中国康复理论与实践》, 2019, 25(2): 172-177.

HU Ying-ying, YING Jin-wei, ZHAO Qi-wen. Application of Magnetic Resonance Mapping in Progressive Intervertebral Disc Degeneration in Rabbits[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(2): 172-177.

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磁共振Mapping技术诊断兔进展期椎间盘退变

Application of Magnetic Resonance Mapping in Progressive Intervertebral Disc Degeneration in Rabbits

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