太极拳锻炼对慢性失眠障碍患者睡眠质量的影响

doi:10.3969/j.issn.1006-9771.2019.02.019

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (2): 230-233.doi: 10.3969/j.issn.1006-9771.2019.02.019

太极拳锻炼对慢性失眠障碍患者睡眠质量的影响

周清安^1,2,3，王献红³, 祝希泉⁴, 余海滨⁵, 刘金来², 杨利杰², 王林², 杨波², 李春梅², 李红艳²

1. 新乡医学院三全学院，河南新乡市 453003
2. 河南理工大学第一附属医院，河南焦作市 454000
3. 郑州澍青医学高等专科学校，河南郑州市 450064
4. 全军精神疾病防治研究所，河南焦作市 454003
5. 河南中医药大学第一附属医院，河南郑州市 450000

收稿日期:2018-02-06 修回日期:2018-11-04 出版日期:2019-02-25 发布日期:2019-04-01
通讯作者: 祝希泉。E-mail: zhuxiquan@aliyun.com
作者简介:周清安(1968-)，男，汉族，河南信阳市人，医学博士，教授，副主任医师，主要研究方向：血管性神经病，失眠症、神经症以及中药药理与临床。
基金资助:
1.军区后勤科研计划项目(No. JN13W027)

Effect of Taiji Quan on Sleep Quality of Patients with Chronic Insomnia Disorder

ZHOU Qing-an^{1, 2, 3}, WANG Xian-hong³, ZHU Xi-quan⁴, YU Hai-bin⁵, LIU Jin-lai², YANG Li-jie², WANG Lin², YANG Bo², LI Chun-mei², LI Hong-yan²

1. Sanquan Medical College of Xinxiang Medical University, Xinxiang, Henan 453003, China
2. The First Affiliated Hospital of Henan Polytechnic University, Jiaozuo, Henan 454000, China
3. Zhengzhou Shuqing Medical College, Zhengzhou, Henan 450064, China
4. The Mental Diseases Prevention and Treatment Center of the Chinese PLA, Jiaozuo, Henan 454003, China
5. The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China

Received:2018-02-06 Revised:2018-11-04 Published:2019-02-25 Online:2019-04-01
Contact: ZHU Xi-quan. E-mail: zhuxiquan@aliyun.com
Supported by:
Military Logistics Research Plan (No. JN13W027)

摘要/Abstract

摘要： 目的观察太极拳锻炼对慢性失眠障碍(CID)患者睡眠质量的影响，并探讨其作用机制。方法收集2015年1月至2017年12月在睡眠障碍门诊就诊的CID患者31例。太极拳锻炼24周前后，采用匹兹堡睡眠质量指数(PSQI)评估患者睡眠质量；采用蛋白芯片检测患者血清肿瘤坏死因子(TNF)-α、TNF-β和可溶性肿瘤坏死因子受体(sTNF-R)1、sTNF-R2水平，并分析锻炼后PSQI评分与之相关性。结果太极拳锻炼24周后，CID患者PSQI各因子(睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能)评分及PSQI总分均较锻炼前降低(t > 4.080, P < 0.05)；血清TNF-α、TNF-β水平明显下降(t > 13.580, P < 0.01)，血清sTNF-R1、sTNF-R2水平显著上升(t > 160.189, P < 0.001)；血清TNF-α、TNF-β水平与PSQI评分呈显著正相关(r > 0.638, P < 0.001)，而血清sTNF-R1、sTNF-R2水平与PSQI评分呈显著负相关(r < -0.532, P < 0.001)。结论 CID患者太极拳锻炼后睡眠质量改善，可能与降低血清TNF-α、TNF-β水平，上调血清sTNF-R1、sTNF-R2水平有关。

关键词: 慢性失眠障碍, 太极拳, 匹兹堡睡眠质量指数, 肿瘤坏死因子, 可溶性肿瘤坏死因子受体

Abstract: Objective To explore the effect of Taiji Quan on the sleep quality of patients with chronic insomnia disorder (CID) and its mechanism. Methods From January, 2015 to December, 2017, 31 patients with CID were enrolled in the sleep disorder clinic. Before and 24 weeks after Taiji Quan exercise, the Pittsburgh Sleep Quality Index (PSQI) was used to assess their sleep quality, the serum levels of tumor necrosis factor (TNF)-α, TNF-β, soluble tumor necrosis factor receptor (sTNF-R)1 and sTNF-R2 were detected with protein chip, and the correlation between the total score of PSQI and the serum levels of TNF-α, TNF-β, sTNF-R1 and sTNF-R2 were analyzed after exercise. Results After Taiji Quan exercise, the scores of PSQI factors (subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, daytime dysfunction) and the total score of PSQI decreased (t > 4.080, P < 0.05). The serum levels of TNF-α and TNF-β decreased (t > 13.580, P < 0.01), however, the serum levels of sTNF-R1 and sTNF-R2 significantly increased (t > 160.189, P < 0.001). The serum levels of TNF-α and TNF-β were positively correlated with the total score of PSQI (r > 0.638, P < 0.001), while the serum levels of sTNF-R1 and sTNF-R2 were negatively correlated with the total score of PSQI (r > 0.532, P<0.001). Conclusion Taiji Quan exercise could help to improve the sleep quality of patients with CID. The mechanism may be related to the decrease of the serum levels of TNF-α and TNF-β, and the increase of the serum levels of sTNF-R1 and sTNF-R2.

Key words: chronic insomnia disorder, Taiji Quan, Pittsburgh Sleep Quality Index, tumor necrosis factor, soluble tumor necrosis factor receptor

中图分类号:

R749.7

周清安, 王献红, 祝希泉, 余海滨, 刘金来, 杨利杰, 王林, 杨波, 李春梅, 李红艳. 太极拳锻炼对慢性失眠障碍患者睡眠质量的影响[J]. 《中国康复理论与实践》, 2019, 25(2): 230-233.

ZHOU Qing-an, WANG Xian-hong, ZHU Xi-quan, YU Hai-bin, LIU Jin-lai, YANG Li-jie, WANG Lin, YANG Bo, LI Chun-mei, LI Hong-yan. Effect of Taiji Quan on Sleep Quality of Patients with Chronic Insomnia Disorder[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(2): 230-233.

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太极拳锻炼对慢性失眠障碍患者睡眠质量的影响

Effect of Taiji Quan on Sleep Quality of Patients with Chronic Insomnia Disorder

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