运动诱导细胞自噬在老年肌少症康复中的研究进展

doi:10.3969/j.issn.1006-9771.2019.03.015

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (3): 334-337.doi: 10.3969/j.issn.1006-9771.2019.03.015

运动诱导细胞自噬在老年肌少症康复中的研究进展

梁计陵¹, 谢金凤¹, 王岑依², 陈宁³

1.武汉体育学院研究生院，湖北武汉市 430079
2.杜肯大学兰格斯健康科学学院，美国宾夕法尼亚州匹兹堡 PA 15282
3.武汉体育学院健康科学学院，运动训练监控湖北省重点实验室，天久运动营养食品研发中心，湖北武汉市 430079

收稿日期:2018-08-31 修回日期:2018-10-19 出版日期:2019-03-25 发布日期:2019-04-02
通讯作者: 陈宁,E-mail: nchen510@gmail.com
作者简介:梁计陵(1993-)，男，瑶族，湖南怀化市人，硕士研究生，主要研究方向：运动与营养干预对慢性疾病康复。通讯作者：陈宁(1972-)，男，汉族，湖北武汉市人，博士，教授，博士研究生导师，主要研究方向：运动与营养干预对慢性疾病预防与康复。
基金资助:
1. 国家自然科学基金面上项目(No. 31571228)；2. 湖北省体育教育与健康促进学科群项目；3. 湖北省高等学校优秀中青年科技创新团队项目(No. T201624)

Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)

LIANG Ji-ling¹, XIE Jin-feng¹, WANG Cen-yi², CHEN Ning³

1.Graduate School, Wuhan Sports University, Wuhan, Hubei 430079, China
2.John G. Rangos Sr. School of Health Sciences, Duquesne University, Pittsburgh PA15282, USA
3.Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan, Hubei 430079, China

Received:2018-08-31 Revised:2018-10-19 Published:2019-03-25 Online:2019-04-02
Contact: CHEN Ning, E-mail: nchen510@gmail.com
Supported by:
National Natural Science Foundation of China (General) (No. 31571228), Hubei Sports Education and Health Promotion Discipline Group?Foundation and Hubei Scientific?and?Technological Innovation Team Program Foundation?for?Middle-aged?and?Young?Scientist (No. T201624)

摘要/Abstract

摘要： 老年肌少症是一种与衰老相关的疾病，由于蛋白质合成和降解两者之间的不平衡，导致骨骼肌肉的质量和强度的降低。细胞自噬作为调节体内蛋白质代谢平衡的保守机制，能够被运动诱导的腺苷酸活化蛋白激酶(AMPK)、胰岛素样生长因子(IGF)/蛋白激酶B (Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)及磷脂酰肌醇3激酶(PI3K)/Akt/mTOR等多条信号通路途径调节。而运动激活的细胞自噬调控不同生理病理条件下骨骼肌重塑与内环境稳态的稳定，是骨骼肌健康维持的关键。本文总结不同运动诱导的细胞自噬在老年肌少症的预防、治疗和康复中的作用与潜在的分子机制。

关键词: 肌少症, 细胞自噬, 运动干预, 信号通路调控, 综述

Abstract: arcopenia is an aging-related disease with a significant reduction in mass and strength of skeletal muscle due to the imbalance between protein synthesis and degradation. Autophagy acts as a conserved mechanism regulating the balance of protein metabolism in body and can be regulated by multiple signaling pathways such as AMP-activated protein kinase (AMPK), insulin like growth factor (IGF)/ protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) and phosphatidylinositol 3 kinase (PI3K)/Akt/mTOR induced by exercise. Exercise-activated autophagy regulates skeletal muscle remodeling and homeostasis under different physiological and pathological conditions, which is the key to skeletal muscle health maintenance. This article reviewed the regulator roles and potential molecular mechanisms of varying exercise-induced autophagy in the prevention, treatment and rehabilitation of sarcopenia.

Key words: sarcopenia, autophagy, exercise intervention, signal pathway, review

中图分类号:

R746.4

梁计陵, 谢金凤, 王岑依, 陈宁. 运动诱导细胞自噬在老年肌少症康复中的研究进展[J]. 《中国康复理论与实践》, 2019, 25(3): 334-337.

LIANG Ji-ling, XIE Jin-feng, WANG Cen-yi, CHEN Ning. Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(3): 334-337.

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运动诱导细胞自噬在老年肌少症康复中的研究进展

Regulatory Role of Exercise-induced Autophagy in Rehabilitation of Sarcopenia (review)

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