IκB激酶β在脊髓损伤后炎症反应机制中作用的研究进展

doi:10.3969/j.issn.1006-9771.2019.06.003

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (6): 634-637.doi: 10.3969/j.issn.1006-9771.2019.06.003

IκB激酶β在脊髓损伤后炎症反应机制中作用的研究进展

唐瑞苓^1,2, 李敏^1,2, 汪俊宇^1,2, 向武^1,2, 张安仁²

1.成都中医药大学，四川成都市 610037;
2.中国人民解放军西部战区总医院康复医学科，四川成都市 610083

收稿日期:2019-04-15 修回日期:2019-05-16 发布日期:2019-06-25
通讯作者: 张安仁，E-mail: 1518526780@qq.com
作者简介:唐瑞苓(1992-)，女，汉族，四川广元市人，硕士研究生，主要研究方向：脊髓损伤康复的临床及基础研究。
基金资助:
国家自然科学基金面上项目(No. 81674044)

Advance in Role of IκB Kinase beta in Inflammatory Response Mechanism post Spinal Cord Injury (review)

TANG Rui-ling^1,2, LI Min^1,2, WANG Jun-yu^1,2, XIANG Wu^1,2, ZHANG An-ren²

1.Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610037, China;
2.Department of Rehabilitation Medicine, the General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China

Received:2019-04-15 Revised:2019-05-16 Online:2019-06-25
Contact: ZHANG An-ren, E-mail: 1518526780@qq.com
Supported by:
National Natural Science Foundation of China (General) (No. 81674044)

摘要/Abstract

摘要： IκB激酶β (IKKβ)是核因子κB (NF-κB)信号通路中的关键激酶。在脊髓损伤后，IKKβ被活化，NF-κB信号通路异常激活，产生大量炎症因子，对脊髓损伤后的恢复产生不利影响。本文主要对IKKβ的结构功能及其在脊髓损伤后炎症反应中的应用进行综述，试图寻找一种治疗脊髓损伤的新靶点。

关键词: IκB激酶β, 脊髓损伤, 炎症反应, 核因子κB, 综述

Abstract: IκB kinase beta (IKKbeta) is a key kinase in nuclear factor kappa B (NF-kappaB) signaling pathway. After spinal cord injury, IKKbeta is activated, and the signal pathway of NF-kappa B is abnormally activated, which produces a large number of inflammatory factors, which has a negative impact on the recovery of spinal cord injury. This article mainly summarized the structure and function of IKKbeta and its application in inflammatory reaction after spinal cord injury, trying to find a new target for the treatment of spinal cord injury.

Key words: IκB kinase beta, spinal cord injury, inflammatory response, nuclear factor kappa B, review

中图分类号:

R651.2

唐瑞苓, 李敏, 汪俊宇, 向武, 张安仁. IκB激酶β在脊髓损伤后炎症反应机制中作用的研究进展[J]. 《中国康复理论与实践》, 2019, 25(6): 634-637.

TANG Rui-ling, LI Min, WANG Jun-yu, XIANG Wu, ZHANG An-ren. Advance in Role of IκB Kinase beta in Inflammatory Response Mechanism post Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(6): 634-637.

参考文献

1 王涛丽,顾兵,李华南,等. 急性脊髓损伤后的炎症反应及其抗炎治疗[J]. 中国药理学报, 2015, 31(4): 452-457.
2 AnwarM A, ShehabiT S A, EidA H. Inflammogenesis of secondary spinal cord injury [J]. Front Cell Neurosci, 2016, 10(98): 1-24.
3 VallabhapurapuS, KarinM. Regulation and function of NF-kappaB transcription factors in the immune system [J]. Annu Rev Immunol, 2009, 27: 693-733.
4 BetheaJ R, CastroM, KeaneR W, et al. Traumatic spinal cord injury induces nuclear factor-kappaB activation [J]. J Neurosci, 1998, 18(9): 3251-3260.
5 HerrmannO, BaumannB, de LorenziR, et al. IKK mediates ischemia-induced neuronal death [J]. Nat Med, 2005, 11(12): 1322-1329.
6 YamamotoY, GaynorR B. IkappaB kinases: key regulators of the NF-kappaB pathway [J]. Trends Biochem Sci, 2004, 29(2): 72-79.
7 韩鑫. 抑制 IKK/NF-κB信号通路在脊髓损伤中的作用及其机制的实验研究[D]. 大连: 大连医科大学, 2012.
8 RafatiD S, GeisslerK, JohnsonK, et al. Nuclear factor-kappaB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes [J]. J Neurosci Res, 2008, 86(3): 566-580.
9 扈玉华,史学芳,卢圣奎,等. 大鼠实验性急性脊髓损伤时 NF-κB 表达的研究[J]. 河北医科大学学报, 2003, 24(1): 1-3.
10 EllmanD G, NovrupH G, JorgensenL H, et al. Neuronal ablation of IKK2 decreases lesion size and improves functional outcome after spinal cord injury in mice [J]. JSM Neurosurg Spine, 2017, 5(3): 1090.
11 HaydenM S, GhoshS. Shared principles in NF-kappaB signaling [J]. Cell, 2008, 132(3) :344-362.
12 HinzM, ScheidereitC. The IkappaB kinase complex in NF-kappaB regulation and beyond [J]. EMBO Rep, 2014, 15(1): 46-61.
13 LiJ, PeetG W, PullenS S, et al. Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha [J]. J Biol Chem, 1998, 273(46): 30736-30741.
14 RothschildD E, McDanielD K, Ringel-ScaiaV M, et al. Modulating inflammation through the negative regulation of NF-kappaB signaling [J]. J Leukoc Biol, 2018, 103(6): 1131-1150.
15 MercurioF, ZhuH, MurrayB W, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation [J]. Science, 1997, 278(5339): 860-866.
16 于锦超,于敏,莫炜. NF-κB信号通路在肿瘤发生和炎症反应中的作用[J]. 药物生物技术, 2016, 23(1): 82-85.
17 张芸,张崇高,许化溪. 缺氧诱导因子与炎症及肿瘤的关系[J]. 中国药理学通报, 2007, 23(1): 17-19.
18 GretenF R, EckmannL, GretenT F, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer [J]. Cell, 2004, 118(3): 285-296.
19 NauglerW E, SakuraiT, KimS, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production [J]. Science, 2007, 317(5834): 121-124.
20 TranP O, GleasonC E, RobertsonR P. Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function [J]. Diabetes, 2002, 51(6): 1772-1778.
21 YinM J, YamamotoY, GaynorR B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta [J]. Nature, 1998, 396(6706): 77-80.
22 PannickeU, BaumannB, FuchsS, et al. Deficiency of innate and acquired immunity caused by an IKBKB mutation [J]. N Engl J Med, 2013, 369(26): 2504-2514.
23 方康权,曾宪辉. 脊髓损伤的生物化学研究概况[J]. 医学理论与实践, 2018, 31(18): 2723-2724, 2727.
24 MortazaviM M, VermaK, HarmonO A, et al. The microanatomy of spinal cord injury: a review [J]. Clin Anat, 2015, 28(1): 27-36.
25 周红英,戚观树,侯群. 脊髓损伤的发病机制及治疗进展[J]. 中华中医药学刊, 2012, 30(4): 769-772.
26 AllisonD J, DitorD S. Immune dysfunction and chronic inflammation following spinal cord injury [J]. Spinal Cord, 2015, 53(1): 14-18.
27 DavidS, ZarrukJ G, GhasemlouN. Inflammatory pathways in spinal cord injury [J]. Int Rev Neurobiol, 2012, 106: 127-152.
28 BosmiaA N, HoganE, LoukasM, et al. Blood supply to the human spinal cord: part I. Anatomy and hemodynamics [J]. Clin Anat, 2015, 28(1): 52-64.
29 ZhangH, ParkY, WuJ, et al. Role of TNF-alpha in vascular dysfunction [J]. Clin Sci (Lond), 2009, 116(3): 219-230.
30 GarshickE, KelleyA, CohenS A, et al. A prospective assessment of mortality in chronic spinal cord injury [J]. Spinal Cord, 2005, 43(7): 408-416.
31 AnwarM A, Al ShehabiT S, EidA H. Inflammogenesis of secondary spinal cord injury [J]. Front Cell Neurosci, 2016, 10: 98.
32 StonerL, SabatierM, VanhHielL, et al. Upper vs lower extremity arterial function after spinal cord injury [J]. J Spinal Cord Med, 2006, 29(2): 138-146.
33 HaydenM S, GhoshS. NF-κB, the first quarter-century: remarkable progress and outstanding questions [J]. Genes Dev, 2012, 26(3): 203-234.
34 林时凡. NF-κB在急性脊髓损伤中的研究现状及前景 [J]. 现代医药卫生, 2011, 27(14): 2147-2150.
35 BetheaJ R, MarciaC, KeaneR W, et al. Traumatic spinal cord injury induces nuclear factor-κB activation [J]. J Neurosci, 1998, 18(9): 3251-3260.
36 SakuraiH, SuzukiS, KawasakiN, et al. Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway [J]. J Biol Chem, 2003, 278(38): 36916-36923.
37 MbalavieleG, SommersC D, BonarS L, et al. A novel, highly selective, tight binding IκB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-κB pathway in arthritis-relevant cells and animal models [J]. J Pharmacol Exp Ther, 2009, 329(1): 14-25.
38 BrambillaR, Bracchi-RicardV, HuW H, et al. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury [J]. J Exp Med, 2005, 202(1): 145-156.
39 Jimenez-GarzaO, CamachoJ, IbarraA, et al. Early effects of modulating nuclear factor-kappaB activation on traumatic spinal cord injury in rats [J]. Ann N Y Acad Sci, 2005, 1053: 148-150.
40 LiuG, FanG, GuoG, et al. FK506 attenuates the inflammation in rat spinal cord injury by inhibiting the activation of NF-κB in microglia cells [J]. Cell Mol Neurobiol, 2017, 37(5): 843-855.
41 NiH, JinW, ZhuT, et al. Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats [J]. J Spinal Cord Med, 2015, 38(2): 199-206.
42 XuL, BotchwayB O A, ZhangS, et al. Inhibition of NF-κB signaling pathway by resveratrol improves spinal cord injury [J]. Front Neurosci, 2018, 12: 690.
43 KangJ, JiangM H, MinH J, et al. IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury [J]. Eur J Immunol, 2011, 41(5): 1266-1277.
44 RafatiD S, GeisslerK, JohnsonK, et al. Nuclear factor-kappaB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes [J]. J Neurosci Res, 2008, 86(3): 566-580.
45 杨新平. 右美托咪定对大鼠急性脊髓损伤后的神经保护作用及其机制的实验研究[D].合肥: 安徽医科大学, 2017.

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IκB激酶β在脊髓损伤后炎症反应机制中作用的研究进展

Advance in Role of IκB Kinase beta in Inflammatory Response Mechanism post Spinal Cord Injury (review)

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