脊髓损伤后肢体痉挛机制的研究进展

doi:10.3969/j.issn.1006-9771.2019.06.004

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (6): 638-643.doi: 10.3969/j.issn.1006-9771.2019.06.004

脊髓损伤后肢体痉挛机制的研究进展

樊亮花¹, 杜良杰^1,2

1.首都医科大学康复医学院，北京市 100068;
2.中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科，北京市 100068

收稿日期:2018-11-10 修回日期:2019-01-24 发布日期:2019-06-25
通讯作者: 杜良杰，E-mail: strongneck@qq.com
作者简介:樊亮花(1992-)，女，汉族，安徽蚌埠市人，硕士研究生，主要研究方向：脊柱脊髓损伤康复。
基金资助:
北京市科委“首都临床特色应用研究”项目(No. Z171100001017026)

Advance in Mechanism of Limb Spasm after Spinal Cord Injury (review)

FAN Liang-hua¹, DU Liang-jie^1,2

1.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China;
2.Department of Spinal Cord Neural Functional Reconstruction, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China

Received:2018-11-10 Revised:2019-01-24 Online:2019-06-25
Contact: DU Liang-jie, E-mail: strongneck@qq.com
Supported by:
Beijing Municipal Commission of Science and Technology Capital Clinical Characteristic Application Research Project (No. Z171100001017026)

摘要/Abstract

摘要： 脊髓损伤患者常伴发肢体痉挛，影响日常生活和康复进展。脊髓损伤后，脊髓兴奋性网络、突触前抑制和运动神经元兴奋性之间的动态平衡被打破，运动神经元的活动背景发生变化，细胞膜上离子通道、5-羟色胺受体、转运体浓度的改变等共同作用，促进痉挛的形成和发展。

关键词: 脊髓损伤, 痉挛, 发病机制, 综述

Abstract: After spinal cord injury, patients often suffer from limb spasm, which affects their daily life and the progress of rehabilitation. Balance among spinal cord excitability network, presynaptic inhibition and motor neuron excitability was broken, background of motor neuron activity changed, membrane ion channels, serotonin receptors and transporter concentration changed after spinal cord injury, which promote formation and development of spasm.

Key words: spinal cord injury, spasm, pathogenesis, review

中图分类号:

R651.2

樊亮花, 杜良杰. 脊髓损伤后肢体痉挛机制的研究进展[J]. 《中国康复理论与实践》, 2019, 25(6): 638-643.

FAN Liang-hua, DU Liang-jie. Advance in Mechanism of Limb Spasm after Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(6): 638-643.

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脊髓损伤后肢体痉挛机制的研究进展

Advance in Mechanism of Limb Spasm after Spinal Cord Injury (review)

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