上肢截肢者大脑运动皮质区神经可塑性的研究进展

doi:10.3969/j.issn.1006-9771.2019.07.012

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (7): 801-804.doi: 10.3969/j.issn.1006-9771.2019.07.012

上肢截肢者大脑运动皮质区神经可塑性的研究进展

郝莹¹, 郭峰²

1.沈阳体育学院研究生部；辽宁沈阳市 110102
2.沈阳体育学院运动人体科学学院，辽宁沈阳市 110102

收稿日期:2018-11-14 修回日期:2019-02-03 出版日期:2019-07-25 发布日期:2019-07-23
通讯作者: 郭峰 E-mail:guofeng_first@163.com
作者简介:郝莹(1994-)，女，汉族，吉林公主岭市人，硕士研究生，主要研究方向：运动康复。
基金资助:
1.国家自然科学基金项目(No. 31701043)；2.辽宁省自然科学基金项目(No. 20180550169)；3.辽宁省“百千万人才工程”资助项目；4.科技部国家重点研发计划子课题(No. 2018YFF0300502)

Advance in Neural Plasticity of Cerebral Motor Cortex for Upper-limb Amputee (review)

HAO Ying¹, GUO Feng²

1.Department of Postgraduates; b. College of Human Kinesiology, Shenyang Sport University, Shenyang, Liaoning 110102, China
2.Department of Postgraduates; b. College of Human Kinesiology, Shenyang Sport University, Shenyang, Liaoning 110102, China

Received:2018-11-14 Revised:2019-02-03 Published:2019-07-25 Online:2019-07-23
Contact: GUO Feng E-mail:guofeng_first@163.com
Supported by:
Supported by National Natural Science Foundation of China (No. 31701043), Natural Science Foundation of Liaoning Province (No. 20180550169), Liaoning Bai-Qian-Wan Talents Program, Subtopics of Ministry of Science and Technology National Key Research and Development Program (No. 2018YFF0300502)

摘要/Abstract

摘要： 上肢截肢后发生的神经传导阻滞、本体感觉缺失和幻肢痛都可能引起大脑神经可塑性变化，镜像神经元系统也对学习能力有重要影响。但相关研究甚少，上肢截肢者残肢或假肢的运动控制与学习的中枢机制还需进一步研究。

关键词: 上肢截肢, 大脑, 运动皮质区, 神经可塑性, 综述

Abstract: Nerve conduction block, proprioceptive loss and phantom limb pain after amputation may result in brain plasticity. In addition, the mirror neuron system of amputees plays an important role in their learning ability. However, there are few studies on adaptability of the motor cortex in upper limb amputees, and the central mechanism of motor control and learning of the residual limb or prosthesis needs more studies.

Key words: upper-limb amputation, brain, motor cortex, neural plasticity, review

中图分类号:

R687.5

郝莹, 郭峰. 上肢截肢者大脑运动皮质区神经可塑性的研究进展[J]. 《中国康复理论与实践》, 2019, 25(7): 801-804.

HAO Ying, GUO Feng. Advance in Neural Plasticity of Cerebral Motor Cortex for Upper-limb Amputee (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(7): 801-804.

参考文献

1 世界卫生组织. 世界残疾报告(概要)[J]. 中国康复理论与实践, 2011, 17(6): 501-507.
2 李晞,吴小高. 我国残疾人辅助器具服务工作的现状及展望[J]. 残疾人研究, 2016(3): 43-47.
3 SchofieldJ S, EvansK R, CareyJ P, et al. Applications of sensory feedback in motorized upper extremity prosthesis: a review [J]. Expert Rev Med Devices, 2014, 11(5): 499-511.
4 van TwillertS, GeertzenJ, HemmingaT, et al. Reconsidering evidence-based practice in prosthetic rehabilitation: a shared enterprise [J]. Prosthet Orthot Int, 2013, 37(3): 203-211.
5 SawersA, HahnM E, KellyV E, et al. Beyond componentry: How principles of motor learning can enhance locomotor rehabilitation of individuals with lower limb loss: a review [J]. J Rehabil Res Dev, 2013, 49(10): 1431-1442.
6 陈燕才. 单自由度肌电手与前臂真肢对比分析指导前臂截肢患者康复训练的研究[D]. 广州:南方医科大学, 2018.
7 WheatonL A. Neurorehabilitation in upper limb amputation: understanding how neurophysiological changes can affect functional rehabilitation [J]. J Neuroeng Rehabil, 2017, 14(1): 41-53.
8 MakinT R, CramerA O, ScholzJ, et al. Deprivation-related and use-dependent plasticity go hand in hand [J]. eLife, 2013, 2: e01273.
9 蒋光耀. 截肢后脑可塑性的磁共振成像研究[D]. 重庆:第三军医大学, 2016.
10 Janz VernoskiJ L, BjorklandJ R, KramerT J, et al. A simple non-invasive method for temporary knockdown of upper limb proprioception [J]. J Vis Exp, 2018(133): e57218.
11 ImamizuH, KawatoM. Brain mechanisms for predictive control by switching internal models: implications for higher-order cognitive functions [J]. Psychol Res, 2009, 73(4): 527-544.
12 WerhahnK J, MortensenJ, Kaelin-LangA, et al. Cortical excitability changes induced by deafferentation of the contralateral hemisphere [J]. Brain, 2002, 125(6): 1402-1413.
13 WerhahnK J, MortensenJ, BovenR W V, et al. Enhanced tactile spatial acuity and cortical processing during acute hand deafferentation [J]. Nat Neurosci, 2002, 5(10): 936-938.
14 ThomasF A, DietzV, ScharfenbergerT, et al. Cooperative hand movements: effect of a reduced afference on the neural coupling mechanism [J]. Neuroreport, 2018, 29(8): 650-654.
15 MizelleJ, OparahA, WheatonL. Reliability of visual and somatosensory feedback in skilled movement: the role of the cerebellum [J]. Brain Topogr, 2016, 29(1): 1-15.
16 BeauchampM S, LaconteS, YasarN. Distributed representation of single touches in somatosensory and visual cortex [J]. Hum Brain Mapp, 2009, 30(10): 3163-3171.
17 WitscherK. Assessment of reorganization in the sensorimotor cortex after upper limb amputation [J]. Clin Neurophysiol, 2001, 112(4): 627-635.
18 马春莲, 杨翼. 运动影响脑可塑性及其分子机制研究进展[J]. 中国运动医学杂志, 2015, 34(8): 810-814.
19 KobayashiM, ThéoretH, Pascual-LeoneA. Suppression of ipsilateral motor cortex facilitates motor skill learning [J]. Eur J Neurosci, 2009, 29(4): 833-836.
20 PhilipB A, FreyS H. Preserved grip selection planning in chronic unilateral upper extremity amputees [J]. Exp Brain Res, 2011, 214(3): 437-452.
21 FristonK J, DaunizeauJ, KilnerJ, et al. Action and behavior: a free-energy formulation [J]. Biol Cybern, 2010, 102(3): 227-260.
22 GiacomoR, LeonardoF. The mirror mechanism: recent findings and perspectives [J]. Philos Trans R Soc Lond B Biol Sci, 2014, 369(1644): 20130420.
23 BruckerB, EhlisA C,H?u?ingerF B, et al. Watching corresponding gestures facilitates learning with animations by activating human mirror-neurons: an fNIRS study [J]. Learning Instr, 2015, 36: 27-37.
24 ZultT, HowatsonG, KádárE E, et al. Role of the mirror-neuron system in cross-education [J]. Sports Med, 2014, 44(2): 159-178.
25 TaiY F, ScherflerC, BrooksD J, et al. The human premotor cortex is “mirror” only for biological actions [J]. Curr Biol, 2004, 14(2): 117-120.
26 CusackW F, MichaelC, SherylN, et al. Neural activation differences in amputees during imitation of intact versus amputee movements [J]. Front Hum Neurosci, 2012, 6: 182.
27 LawsonD T, CusackW F, LawsonR, et al. Influence of perspective of action observation training on residual limb control in naive prosthesis usage [J]. J Mot Behav, 2016, 48(5): 446-454.
28 王磊,孙海钰. 幻肢痛临床治疗新进展[J]. 中国民康医学, 2018, 30(4): 73-75.
29 田中义,郝涌刚,刘新伟. 幻肢痛发病机制研究及临床治疗新进展[J]. 中国康复医学杂志, 2016, 31(1): 110-114.
30 EyeshaH, RowleyC D, SharonG, et al. Patterns of myeloarchitecture in lower limb amputees: an MRI study [J]. Front Neurosci, 2015, 9: 15.
31 GuangyaoJ, XuntaoY, ChuanmingL, et al. The plasticity of brain gray matter and white matter following lower limb amputation [J]. Neural Plast, 2015, 2015: 823185.
32 SimoesE L, BramatiI, RodriguesE, et al. Functional expansion of sensorimotor representation and structural reorganization of callosal connections in lower limb amputees [J]. J Neurosci, 2012, 32 (9): 3211-3220.
33 KarlA, BirbaumerN, LutzenbergerW, et al. Reorganization of motor and somatosensory cortex in upper extremity amputees with phantom limb pain [J]. J Neurosci, 2001, 21(10): 3609-3618.
34 SanneK, HeidiJ B, IreneT, et al. Reaffirming the link between chronic phantom limb pain and maintained missing hand representation [J]. Cortex, 2018, 106: 174-184.
35 AlviarM J, DungcaM, HaleT. Pharmacologic interventions for treating phantom limb pain [J]. Cochrane Database Syst Rev, 2016, 10: CD006380.
36 TungM L, MurphyI C, GriffinS C, et al. Observation of limb movements reduces phantom limb pain in bilateral amputees [J]. Ann Clin Transl Neurol, 2014, 1(9): 633-638.
37 MorganS J, FriedlyJ L, AmtmannD, et al. A cross-sectional assessment of factors related to pain intensity and pain interference in lower limb prosthesis users [J]. Arch Phys Med Rehabil, 2017, 98(1): 105-113.
38 GagnéM, HétuS, ReillyK T, et al. The map is not the territory: motor system reorganization in upper limb amputees [J]. Hum Brain Mapp, 2015, 32(4): 509-519.
39 WilliamsL, PirouzN, MizelleJ C, et al. Remodeling of cortical activity for motor control following upper limb loss [J]. Clin Neurophysiol, 2016, 127(9): 3128-3134.

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上肢截肢者大脑运动皮质区神经可塑性的研究进展

Advance in Neural Plasticity of Cerebral Motor Cortex for Upper-limb Amputee (review)

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