米诺环素对脊髓损伤治疗机制的研究进展

doi:10.3969/j.issn.1006-9771.2019.10.006

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (10): 1146-1149.doi: 10.3969/j.issn.1006-9771.2019.10.006

米诺环素对脊髓损伤治疗机制的研究进展

晏荣保, 祁全, 刘杨, 赵鹏, 李成勇, 尹逊屹

哈尔滨医科大学附属第一医院骨科，黑龙江哈尔滨市 150001

出版日期:2019-10-25 发布日期:2019-10-30
通讯作者: 祁全，E-mail: qiquan_harbin@163.com E-mail:qiquan_harbin@163.com
作者简介:晏荣保(1993-)，男，汉族，陕西安康市人，硕士研究生，医师，主要研究方向：脊柱脊髓损伤。
基金资助:
1.哈尔滨市科技创新人才研究专项资金项目(No. 2017RAQXJ185)；2.黑龙江省自然科学基金项目(No. D201262)

Advance in Minocycline for Spinal Cord Injury (review)

YAN Rong-bao, QI Quan, LIU Yang, ZHAO Peng, LI Cheng-yong, YIN Xun-yi

Department of Orthopedics, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China

Published:2019-10-25 Online:2019-10-30
Contact: QI Quan, E-mail: qiquan_harbin@163.com E-mail:qiquan_harbin@163.com
Supported by:
Supported by Foundation:Harbin Special Funds Project for Research of Scientific and Technological Innovative Talents (No. 2017RAQXJ185) and Heilongjiang Natural Science Foundation (No. D201262)

摘要/Abstract

摘要： 脊髓损伤的治疗一直是基础和临床医学领域的研究重点。本文介绍米诺环素治疗脊髓损伤的作用机制，包括抗氧化活性、减少细胞凋亡、抗炎作用、选择性调节小胶质细胞的活化状态等，以及米诺环素相关临床试验的研究进展。米诺环素可以靶向作用于多种继发性损伤机制，促进脊髓损伤恢复，进一步的基础和临床研究将使米诺环素发挥最大化的功效。

关键词: 米诺环素, 脊髓损伤, 作用机制, 临床研究, 综述

Abstract: The treatment of spinal cord injury has been the research priorities in basic and clinical medicine. This article described the mechanism of minocycline in treating spinal cord injury, including antioxidant activity, reduction of apoptosis, anti-inflammatory activity and selective regulation of microglia activation, and recent advances in clinical trials of minocycline. Minocycline targets multiple secondary injury mechanisms to promote the recovery of spinal cord injury, and further basic and clinical research will maximize the efficacy of minocycline.

Key words: minocycline, spinal cord injury, mechanism, clinical research, review

中图分类号:

R651.2

晏荣保, 祁全, 刘杨, 赵鹏, 李成勇, 尹逊屹. 米诺环素对脊髓损伤治疗机制的研究进展[J]. 《中国康复理论与实践》, 2019, 25(10): 1146-1149.

YAN Rong-bao, QI Quan, LIU Yang, ZHAO Peng, LI Cheng-yong, YIN Xun-yi. Advance in Minocycline for Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(10): 1146-1149.

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米诺环素对脊髓损伤治疗机制的研究进展

Advance in Minocycline for Spinal Cord Injury (review)

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