节律性经颅交流电刺激对运动序列学习能力的影响

doi:10.3969/j.issn.1006-9771.2019.11.012

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (11): 1327-1331.doi: 10.3969/j.issn.1006-9771.2019.11.012

节律性经颅交流电刺激对运动序列学习能力的影响

魏泽¹, 许敏鹏^1,2, 明东^1,2, 穆思雨¹

1.天津大学精密仪器与光电子工程学院，天津市 300072
2.天津大学医学工程与转化医学研究院，天津市 300072

收稿日期:2019-05-08 修回日期:2019-05-31 出版日期:2019-11-25 发布日期:2019-11-21
通讯作者: 许敏鹏，E-mail： minpeng.xu@tju.edu.cn E-mail:minpeng.xu@tju.edu.cn
作者简介:魏泽(1995-），女，汉族，天津市人，硕士研究生，主要研究方向：神经调控、脑机接口。
基金资助:
国家自然科学基金项目(No. 81601565； No. 81630051)

Effects of Transcranial Alternating Current Stimulation on Serial Reaction Time Task

WEI Ze¹, XU Min-peng^1,2, MING Dong^1,2, MU Si-yu¹

1.School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072, China
2.Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China

Received:2019-05-08 Revised:2019-05-31 Published:2019-11-25 Online:2019-11-21
Contact: XU Min-peng, E-mail: minpeng.xu@tju.edu.cn E-mail:minpeng.xu@tju.edu.cn
Supported by:
Supported by National Natural Science Foundation of China (No. 81630051; No.81601565)

摘要/Abstract

摘要： 目的探究经颅交流电刺激对脑电节律和认知功能的影响。方法 2017年12月，年轻健康志愿者60例均分为4组，分别采用20 Hz经颅交流电刺激行左侧运动皮层(C3)真/伪刺激或右侧初级运动皮层(C4)真/伪刺激，刺激前后受试者完成左/右手随机/规律按键4种手指序列按键任务，任务过程中采集脑电信号。观察反应时、正确率；脑电信号进行事件相关谱扰动多重差值分析。结果 C4真刺激后，受试者左手任务反应时缩短。结论右侧初级运动皮层20 Hz经颅交流电刺激能提高左侧肢体运动序列学习能力。

关键词: 经颅交流电刺激, 序列反应时任务, 脑电图, 运动学习, 事件相关谱扰动

Abstract: Objective To investigate the effects of transcranial alternating current stimulation (tACS) on electroencephalography (EEG) rhythm and cognitive function. Methods In December, 2017, 60 healthy young volunteers were divided into four groups equally, who accepted 20 Hz real or sham tACS on left C3 or right C4. They were asked to complete four types of finger sequence key pressing tasks (left/right hand random/regular key pressing) before and after stimulation, while the EEG signals were collected and the reaction time and accuracy were observed. EEG signals were analyzed with multiple difference analysis of event-related spectral perturbation. Results The reaction time of contralateral hand reduced after C4 real stimulation. Conclusion Right 20 Hz tACS can improve the learning of contralateral limb sequential movement.

Key words: transcranial alternating current stimulation, serial reaction time task, electroencephalography, motor learning, event-related spectral perturbation

中图分类号:

R454.1

魏泽, 许敏鹏, 明东, 穆思雨. 节律性经颅交流电刺激对运动序列学习能力的影响[J]. 《中国康复理论与实践》, 2019, 25(11): 1327-1331.

WEI Ze, XU Min-peng, MING Dong, MU Si-yu. Effects of Transcranial Alternating Current Stimulation on Serial Reaction Time Task[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(11): 1327-1331.

参考文献

1 MatsuyaR, UshiyamaJ, UshibaJ. Inhibitory interneuron circuits at cortical and spinal levels are associated with individual differences in corticomuscular coherence during isometric voluntary contraction [J]. Sci Rep, 2017, 7: 44417.
2 GuerraA, PogosyanA, NowakM, et al. Phase dependency of the human primary motor cortex and cholinergic inhibition cancelation during beta tACS [J]. Cereb Cortex, 2016, 26(10): 3977-3990.
3 SchilbergL, EngelenT, Ten OeverS, et al. Phase of beta-frequency tACS over primary motor cortex modulates corticospinal excitability [J]. Cortex, 2018, 103: 142-152.
4 关龙舟,魏云,李小俚. 经颅电刺激——一项具有发展前景的脑刺激技术[J]. 中国医疗设备, 2015, 30(11): 1-5.
5 GiovannellaM, Iba?ezD, Gregori-PlaC, et al. Concurrent measurement of cerebral hemodynamics and electroencephalography during transcranial direct current stimulation [J]. Neurophotonics, 2018, 5(1): 015001.
6 耿昌. 中医药综合康复在缺血性脑卒中急性期的作用的研究[D]. 济南:山东中医药大学, 2005.
7 EdagawaK, KawasakiM. Beta phase synchronization in the frontal-temporal-cerebellar network during auditory-to-motor rhythm learning [J]. Sci Rep, 2017, 7: 42721.
8 WesselM J, ZimermanM, HummelF C. Non-invasive brain stimulation: an interventional tool for enhancing behavioral training after stroke [J]. Front Hum Neurosci, 2015, 9: 265.
9 de la SalleS, ChoueiryJ, ShahD, et al. Effects of ketamine on resting-state EEG activity and their relationship to perceptual/dissociative symptoms in healthy humans [J]. Front Pharmacol, 2016, 7: 348.
10 WesterbergC E, FlorczakS M, WeintraubS, et al. Memory improvement via slow oscillatory stimulation during sleep in older adults [J]. Neurobiol Aging, 2015, 36(9): 2577-2586.
11 JohannesV, Huster RenéJ, HerrmannC S. Increase in short-term memory capacity induced by down-regulating individual theta frequency via transcranial alternating current stimulation [J]. Front Hum Neurosci, 2015, 9: 257.
12 SchutteI, KenemansJ L, SchutterD J L G. Resting-state theta/beta EEG ratio is associated with reward-and punishment-related reversal learning [J]. Cogn Affect Behav Ne, 2017, 17(4): 754-763.
13 PollokB, BoysenA C, KrauseV. The effect of transcranial alternating current stimulation (tACS) at alpha and beta frequency on motor learning [J]. Behav Brain Res, 2015, 293: 234-240.
14 NowakM, HinsonE, van EdeF, et al. Driving human motor cortical oscillations leads to behaviorally relevant changes in local GABAA inhibition: a tACS-TMS study [J]. J Neurosci, 2017, 37(17): 4481-4492.
15 HerrmannC S, StrüberD, HelfrichR F, et al. EEG oscillations: from correlation to causality [J]. Int J Psychophysiol, 2016, 103: 12-21.
16 BauerA K R, KreutzG, HerrmannC S. Individual musical tempo preference correlates with EEG beta rhythm [J]. Psychophysiology, 2015, 52(4): 600-604.
17 VossU, HolzmannR, HobsonA, et al. Induction of self awareness in dreams through frontal low current stimulation of gamma activity [J]. Nat Neurosci, 2014, 17(6): 810-812.
18 HiranoM, KubotaS, KoizumeY, et al. Acquisition of motor memory determines the interindividual variability of learning-induced plasticity in the primary motor cortex [J]. J Appl Physiol, 2018, 125(4): 990-998.
19 Fr?hlichF. Endogenous and exogenous electric fields as modifiers of brain activity: rational design of noninvasive brain stimulation with transcranial alternating current stimulation [J]. Dialogues Clin Neuro, 2014, 16(1): 93-102.
20 SalmelaE, RenvallH, KujalaJ, et al. Evidence for genetic regulation of the human parieto‐occipital 10‐Hz rhythmic activity [J]. Eur J Neurosci, 2016, 44(3): 1963-1971.
21 FigueiredoJ, SantosC P, MorenoJ C. Automatic recognition of gait patterns in human motor disorders using machine learning: a review [J]. Med End Phys, 2018, 53: 1-12.
22 RufenerK S, ZaehleT, OechslinM S, et al. 40 Hz-Transcranial alternating current stimulation (tACS) selectively modulates speech perception [J]. Int J Psychophysiol, 2016, 101: 18-24.
23 SamahaJ, IemiL, PostleB R. Prestimulus alpha-band power biases visual discrimination confidence, but not accuracy [J]. Conscious Cogn, 2017, 54: 47-55.
24 GiordanoN, IemoloA, ManciniM, et al. Motor learning and metaplasticity in striatal neurons: relevance for Parkinson's disease [J]. Brain, 2018, 141(2): 505-520.
25 PollokB, OverhagenC L, KeitelA, et al. Transcranial direct current stimulation (tDCS) applied to the left dorsolateral premotor cortex (dPMC) interferes with rhythm reproduction [J]. Sci Rep, 2017, 7(1): 11509.
26 MeissnerS N, KrauseV, SüdmeyerM, et al. The significance of brain oscillations in motor sequence learning: Insights from Parkinson's disease [J]. Neuroimage, 2018, 20: 448-457.

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节律性经颅交流电刺激对运动序列学习能力的影响

Effects of Transcranial Alternating Current Stimulation on Serial Reaction Time Task

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