肠道菌群对脊髓损伤潜在影响的研究进展

doi:10.3969/j.issn.1006-9771.2019.12.011

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (12): 1434-1438.doi: 10.3969/j.issn.1006-9771.2019.12.011

肠道菌群对脊髓损伤潜在影响的研究进展

赵小华^1,2, 周蕊寒^1,2, 郭威³, 庞日朝², 王文春², 张安仁²

1.成都中医药大学养生康复学院，四川成都市 610075
2.西部战区总医院康复医学科，四川成都市 610083
3.乐山市中医医院治未病中心，四川乐山市 614000

收稿日期:2019-05-13 修回日期:2019-06-03 出版日期:2019-12-25 发布日期:2019-12-26
通讯作者: 张安仁，E-mail: 1518526780@qq.com E-mail:1518526780@qq.com
作者简介:赵小华(1993-)，男，汉族，四川达州市人，硕士研究生，主要研究方向：脊髓损伤康复的临床及基础研究。
基金资助:
国家自然科学基金项目(No. 81674044)

Potential Impact of Gut Microbiota on Spinal Cord Injury (review)

ZHAO Xiao-hua^1,2, ZHOU Rui-han^1,2, GUO Wei³, PANG Ri-zhao², WANG Wen-chun², ZHANG An-ren²

1.School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
2.Department of Rehabilitation Medicine, the General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
3.Pre-treatment Center of Leshan Traditional Chinese Medicine Hospital, Leshan, Sichuan 614000, China

Received:2019-05-13 Revised:2019-06-03 Published:2019-12-25 Online:2019-12-26
Contact: ZHANG An-ren, E-mail: 1518526780@qq.com E-mail:1518526780@qq.com
Supported by:
Supported by National Natural Science Foundation of China (No. 81674044)

摘要/Abstract

摘要： 随着微生物组学在中枢神经系统疾病中研究的不断深入，肠道菌群在脊髓损伤中的作用也受到广泛关注。目前主要研究脊髓损伤后肠道菌群的变化特点及菌群代谢产生的芳香烃受体激动剂、短链脂肪酸和脂多糖等对损伤后继发性炎症反应的潜在影响，调节肠道菌群或补充菌群代谢产物可能是治疗脊髓损伤的一条潜在途径。

关键词: 脊髓损伤, 肠道菌群, 炎症, 代谢产物, 芳香烃受体, 短链脂肪酸, 脂多糖, 综述

Abstract: With the deepening of microbial research in central nervous system diseases, the role of gut microbiota in spinal cord injury has also received extensive attention. At present, it is mainly focused on exploring the changes of gut microbiota after spinal cord injury and the potential effects of aryl hydrocarbon receptor agonists, short-chain fatty acids and lipopolysaccharides produced by bacterial metabolism on secondary inflammation after injury, and it is recognized that gut microbiota or supplemental flora metabolites may be a potential pathway for the treatment of spinal cord injury.

Key words: spinal cord injury, gut microbiota, inflammation, metabolites, aryl hydrocarbon receptor, short-chain fatty acids, lipopolysaccharides, review

中图分类号:

R651.2

赵小华, 周蕊寒, 郭威, 庞日朝, 王文春, 张安仁. 肠道菌群对脊髓损伤潜在影响的研究进展[J]. 《中国康复理论与实践》, 2019, 25(12): 1434-1438.

ZHAO Xiao-hua, ZHOU Rui-han, GUO Wei, PANG Ri-zhao, WANG Wen-chun, ZHANG An-ren. Potential Impact of Gut Microbiota on Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(12): 1434-1438.

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肠道菌群对脊髓损伤潜在影响的研究进展

Potential Impact of Gut Microbiota on Spinal Cord Injury (review)

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